Do Multidrug Resistance-Associated Protein-1 and -2 Play Any Role in the Elimination of Estradiol-17β-glucuronide and 2,4-Dinitrophenyl-S-glutathione across the Blood-Cerebrospinal Fluid Barrier?

Journal of Pharmaceutical Sciences

Volumn 93, Issue 1, 2004, Pages 99-107

  Lee, Young Joo ^a   Kusuhara, Hiroyuki ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Active transport; Blood cerebrospinal fluid barrier; CNS; Drug transport; Elimination; Membrane transport transporters; Multidrug resistance transporters; Transgenics

Indexed keywords

2,4 DINITROPHENYL S GLUTATHIONE; ESTRADIOL 17 GLUCURONIDE; GLUTATHIONE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT GENE; KNOCKOUT MOUSE; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT; WILD TYPE;

EID: 0347124816     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10521     Document Type: Article

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