Chemically induced immunotoxicity in a medium-term multiorgan bioassay for carcinogenesis with Wistar rats

Toxicology and Applied Pharmacology

Volumn 194, Issue 2, 2004, Pages 132-140

  Spinardi Barbisan, Ana Lúcia Tozzi ^a   Kaneno, Ramon ^a   Barbisan, Luís Fernando ^a   De Camargo, João Lauro Viana ^a   Rodrigues, Maria Aparecida Marchesan ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Chemical carcinogens; Cytokines; Immunotoxicity; Initiation promotion model; Lymphoid organs

Indexed keywords

1,2 DIMETHYLHYDRAZINE; BIS(2 HYDROXYPROPYL)NITROSAMINE; CARCINOGEN; DIETHYLNITROSAMINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; METHYLNITROSOUREA; N (2 FLUORENYL)ACETAMIDE; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PHENOBARBITAL; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CARCINOGENESIS; CELL LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOPATHOLOGY; IMMUNOTOXICITY; LYMPHOID ORGAN; MALE; NONHUMAN; ORGAN WEIGHT; RAT; SPLEEN CELL; THYMOCYTE;

RATTUS NORVEGICUS;

EID: 0347090546     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.09.012     Document Type: Article

References (48)

1. Balkwill F. Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev. 13:2002;135-141.
2. Barbisan L.F., Miyamoto M., Scolastici C., Salvadori D.M.F., Ribeiro L.R., Eira A.F., de Camargo J.L.V. Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J. Ethnopharmacol. 83:2002;25-32.
3. Brunda M.J., Luistro L., Warrier R.R., Wright R.B., Huddard B.R., Murphy M., Wolf S.F., Gately M.K. Antitumor and antimetastatic activity interleukin 12 against murine tumors. J. Exp. Med. 178:1993;1223-1230.
4. Cohen M.D., Schook L.B., Oppenheim J.J., Freed B.M., Rodgers K.E. Symposium overview: alteration in cytokine receptors by xenobiotics. Toxicol. Sci. 48:1999;163-169.
5. Descotes J., Choquet-Kastylevsky G., Van Ganse E., Vial T. Responses of the immune system to injury. Toxicol. Pathol. 28:2000;479-481.
6. De Wall E.J., Schuurman H.-J., Loeber J.G., Van Loveren H., Vos J.G. Alterations in the cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): an (immuno)histological study. Toxicol. Appl. Pharmacol. 115:1992;80-88.
7. Foster J.R. The functions of cytokines and their uses in toxicology. Int. J. Exp. Pathol. 82:2001;171-192.
8. Franchi C.A.S., Bacchi M.M., Padovani C.R., de Camargo J.L.V. Thymic lymphomas in Wistar rats exposed to N-methyl-N-nitrosourea (MNU). Cancer Sci. 94:2003;240-243.
9. IARC Tumors of the rat. Turusov V.S., Mohr U. Pathology of Tumours in Laboratory Animals. 1990;1-390 International Agency for Research on Cancer, Lyon, France.
10. IARC The use of short-term and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. McGregor D.B., Rice J.M., Venitt S. 1999;1-536 International Agency for Research on Cancer, Lyon, France.
11. Ikeda H., Old L.J., Schreiber R.D. The roles of IFN-γ in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13:2002;95-109.
12. Ito N., Shirai T., Hasegawa R. Medium-term bioassays for carcinogens. Vainio H., Magee P.N., McGregor D.B., McMichael A.J. Mechanisms of Carcinogenesis in Risk Identification. 1992;356-388 International Agency for Research on Cancer, Lyon, France.
13. Ito N., Imaida K., Hirose M., Shirai T. Medium-term bioassays for carcinogenicity of chemical mixtures. Environ. Health Perspect. 106:1998;1331-1336.
14. Kamath A.B., Xu H., Nagarkatti P.S., Nagarkatti M. Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo. Toxicol. Appl. Pharmacol. 142:1997;367-377.
15. Kedderis G.L. Biochemical basis of hepatocellular injury. Toxicol. Pathol. 24:1996;77-83.
16. Kimber I., Dearman R.J. Immune response: adverse versus non-adverse effects. Toxicol. Pathol. 30:2002;54-58.
17. Kitano M., Ichihara T., Matsuda T., Wanibuchi H., Tamano S., Hagiwara A., Imaoka S., Funae Y., Shirai T., Fukushima S. Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogenesis. 19:1998;1475-1480.
18. Koestner A.W., Ruecker F.A., Koestner A. Morphology and pathogenesis of tumors of the thymus and stomach in Sprague-Dawley rats following intragastric administration of methyl nitrosourea (MNU). Int. J. Cancer. 20:1977;418-426.
19. Kuper C.F., Harlerman J.H., Richter-Reichelm H.B., Vos J.G. Histopathologic approaches to detect changes indicative of immunotoxicity. Toxicol. Pathol. 28:2000;454-466.
20. Luster M.I., Rosenthal G.J. Chemical agents and the immune response. Environ. Health Perspect. 100:1993;219-236.
21. Luster M.I., Germolec D.R., Rosenthal G.J. Immunotoxicology: review of current status. Ann. Allergy. 64:1990;427-432.
22. Maekawa A., Onodera H., Ogasawara H., Matsushima Y., Mitsumori K., Hayashi Y. Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine. Carcinogenesis. 13:1992;501-503.
23. Merendino R.A., Gangemi S., Misefari A., Arena A., Capozza A.B., Chillemi S., D'Ambrosio F.P. Interleukin-12 and interleukin 10 production by mononuclear phagocytic cells from breast cancer patients. Immunol. Lett. 68:1999;355-358.
24. Merogi A.J., Marrogi A.J., Ramesh R., Robinson W.R., Fermin C.D., Freeman S.M. Tumor-host interaction: analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas. Hum. Pathol. 28:1997;321-331.
25. Moreira E.L.T., de Camargo J.L.V., Rodrigues M.A.M., Barbisan L.F., Salvadori D.M.F. Dose- and sex-related carcinogenesis by N-bis(2-hydroxypropyl) nitrosamine in Wistar rats. Jpn. J. Cancer Res. 91:2000;368-374.
26. Mossman T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17:1996;138-146.
27. Nastala C.L., Edington H.D., McKinney T.G., Tahara H., Nalesnik M.A., Brunda M.J., Gately M.K., Wolf S.F., Schreiber R.D., Storkus W.J., Lotze M.T. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol. 153:1994;1697-1706.
28. Noguchi Y., Jungbluth A., Richards E.C., Old L.J. Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc. Natl. Acad. Sci. U.S.A. 93:1996;1798-1801.
29. O'Hara R.J., Greenman J., Macdonald A.W., Gaskell K.M., Topping K.P., Duthie G.S., Kerin M.J., Lee P.W.R., Monson J.R.T. Advanced colorectal cancer is associated with impaired interleukin 12 and interleukin 10 production. Clin. Cancer Res. 4:1998;1943-1948.
30. Oppenheim J., Fujiwara H. The role of cytokines in cancer. Cytokine Growth Factor Rev. 7:1996;279-288.
31. + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol. Immunother. 42:1996;1-8.
32. Penninks A.H., Pieters R.H.H., Snoeij N.J., Seinem W. Organotin-induced thymus atrophy. Thymus Update. 4:1991;57-59.
33. Schnellmann R.G. Toxic responses of the kidney. Klaassen C.D. Casarett and Doull's Toxicology: The Basic Science of Poisons. 2001;491-514 McGraw-Hill, USA.
34. Schreiber H., Rowley D.A. Inflammation and cancer. Gallin J.I., Syndeman R. Inflammation: Basic Principles and Clinical Correlates. 1999;1117-1129 Lippincott Williams & Wilkins, Philadelphia.
35. Schuurman H.-J., Kuper C.F. Pathology of the thymus: changes induced by xenobiotics and gene targeting. APMIS. 103:1995;481-500.
36. Schuurman H.-J., Kuper C.F., Vos J.G. Histopathology of the immune system as a tool to assess immunotoxicity. Toxicology. 86:1994;187-212.
37. Seung L.P., Rowley D.A., Schreiber H. Cytokines in cancer. Theze J. The Cytokine Network and Immune Functions. 1999;335-345 Oxford Univ. Press, Oxford.
38. Smyth M.J., Crowe N.Y., Godfrey D.I. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int. Immunol. 13:2001;459-463.
39. Spinardi A.L.T., Kaneno R., Rodrigues M.A.M., Salvadori D.M.F., Rocha N., Barbisan L.F., Ribeiro L.R., de Camargo J.L.V. Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis. Jpn. J. Cancer Res. 90:1999;101-107.
40. Spinardi-Barbisan A.L.T., Kaneno R., Rodrigues M.A.M., Salvadori D.M.F., Moreira E.L.T., Barbisan L.F., de Camargo J.L.V. Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats. Cancer Lett. 154:2000;121-129.
41. Takahashi S., Hasegawa R., Masui T., Misoguchi M., Fukushima S., Ito N. Establishment of multi-organ carcinogenesis bioassay using rats treated with a combination of five different carcinogens. J. Toxicol. Pathol. 5:1992;151-156.
42. Talcott P.A., Exon J.H., Koller L.D. The effects of methylnitrosourea (MNU) on natural killer (NK) cell cytotoxicity and cytokine production in rats. Carcinogenesis. 11:1990;829-834.
43. Tiwawech D., Hasegawa R., Kurata Y., Tatematsu M., Shibata M.-A., Thamavit W., Ito N. Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats. Carcinogenesis. 12:1991;985-990.
44. Trinchieri G. Interleukin-12: a proinflamatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:1995;251-276.
45. Vandebriel R.J., Meredith C., Scott M.P., Roholl P.J.M., van Loveren H. Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels. Toxicol. Appl. Pharmacol. 148:1998;126-136.
46. Vandebriel R.J., Van Loveren H., Meredith C. Altered cytokine (receptor) mRNA expression as a tool in immunotoxicology. Toxicology. 130:1998;43-67.
47. Voccia I., Blakley B., Brousseau P., Fournier M. Immunotoxicity of pesticides: a review. Toxicol. Ind. Health. 15:1999;119-132.
48. Zwiiling B.S., Filppi J.A., Chorpenning F.W., Koestner A., Rheins M.S. Chemical carcinogenesis and immunity: immunologic status of rats treated with methylnitrosourea. J. Natl. Cancer Inst. 61:1978;731-735.