Prevention and Treatment of Excessive Dermal Scarring

Journal of the National Medical Association

Volumn 96, Issue 1, 2004, Pages 108-116

  Roseborough, Ingrid E ^a   Grevious, Mark A ^a   Lee, Raphael C ^a,b  

^a University of Chicago ^*

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Anti inflammatory; Hypertrophic scar; Keloid; Management

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHISTAMINIC AGENT; ANTIINFLAMMATORY AGENT; AVOGEL; AVOSIL; CALCIPOTRIOL; CASPASE 3; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; DIPHENHYDRAMINE; FEXOFENADINE; FLUOROURACIL; GLUCOCORTICOID; HYDROXYZINE; LORATADINE; MANNOSE 6 PHOSPHATE; MITOMYCIN C; SALICYLIC ACID DERIVATIVE; SUTURE MATERIAL; TAMOXIFEN; TRIAMCINOLONE; TRIFLUOPERAZINE; VERAPAMIL;

AFRICAN AMERICAN; ARTICLE; CREAM; DEPIGMENTATION; DROWSINESS; ELECTIVE SURGERY; ESTHETIC SURGERY; HUMAN; HYDROGEL; HYPERTROPHIC SCAR; INFLAMMATION; IONIZING RADIATION; KELOID; LOW ENERGY RADIATION; MEDICAL DECISION MAKING; NOMENCLATURE; OUTCOMES RESEARCH; PATIENT CODING; PRIORITY JOURNAL; PROTECTIVE CLOTHING; SCAR FORMATION; SKIN ATROPHY; SKIN INJURY; SKIN PIGMENTATION; SKIN SCAR; TREATMENT INDICATION; WORLD HEALTH ORGANIZATION; WOUND CARE; WOUND CLOSURE; WOUND DRESSING;

ANTI-INFLAMMATORY AGENTS; CICATRIX, HYPERTROPHIC; CLINICAL PROTOCOLS; HUMANS; KELOID; TERMINOLOGY;

EID: 0347003642     PISSN: 00279684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. International Classification of Diseases -9 DHHS Publication No. 94-1260 U.S. Department of Health and Human Services. October 1994.
2. Ketchum LD, Cohen IK, Masters FW. Hypertrophic scars and keloids. A collective review. Plast Reconstr Surg. 1974;53:140-154.
3. Cosman B, Crikelair GF, Ju DM, et al. The surgical treatment of keloids. Plast Reconstr Surg. 1961;27:335.
4. Santucci M, Borgognoni L, Reali U. Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles. Virchows Arch. 2001;438:457-463.
5. McGrath MH. Peptide growth factors and wound-healing. Clin Plast Surg. 1990;17:421-432.
6. Deitch EA, Wheelahan TM, Rose MP, et al. Hypertrophic burn scars: analysis of variables. J Trauma. 1983;23:895-898.
7. Rudolph R, Vande Berg J, Ehrlich HP. Wound contraction and scar contracture. In Cohen IK, Diegelmann RF, Lindblad WJ: wound-healing: Biochemical and Clinical Aspects. Philadelphia, PA: W.B. Saunders Company. 1992;96-114.
8. Akasaka Y, Ishikawa Y, Ono I, et al. Enhanced expression of caspase-3 in hypertrophic scars and keloid: Induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. Laboratory Investigation. 2000;80:345-357.
9. Tredget EE, Nedelec B, Scott P, et al. Hypertrophic scars, keloids, and contractures: The cellular and molecular basis for therapy. Surg Clin North Am. 1997;77:701-730.
10. Welgus HG, Jeffrey FF, Eisin AZ. The collagen substrate specificity of human skin fibroblast collagenase. J Biol Chem. 1981;256:9511-9515.
11. Curtis AS, Seehar GM. The control of cell division by tension or diffusion. Nature. 1978;274(5666):52-63.
12. Su C, Alizadeh K, Boddie A, et al. The problem scar. Clinics in Plastic Surgery. 1998;25:451-465.
13. Lewis WH, Sun KK. Hypertrophic scar: a genetic hypothesis. Burns. 1990;16:176-178.
14. Schierle HP, Scholz D, Lemperle G. Elevated levels of testosterone receptors in keloid tissue: an experimental investigation. Plast Reconstr Surg. 1997;100;390-396.
15. Castagnoli C, Peruccio D, Stella M, et al. The HLA-DR allogenotype constitutes a risk factor for hypertrophic scarring. Hum Immunol. 1990;29:229-232.
16. McCauley RL, Chopra V, Li YY, et al. Altered cytokine production in black patients with keloids. J Clin Immunol. 1992;12:300-308.
17. Sayah DN, Soo C, Shaw W, et al. Down-regulation of apoptosis-related genes in keloid tissues. J Surg Res. 1999;87:209-216.
18. Tuan TL, Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Molecular Medicine Today. 1998;4:19-24.
19. Boyce DE, Ciampolini J, Ruge F, et al. Inflammatory-cell subpopulations in keloid scars. Brit J Plas Surg. 2001;54:511-516.
20. Cohen JK, Diegelmann RF. The biology of keloid and hypertrophic scar and the influence of corticosteroids. Clin Plast Surg. 1977;4:297-299.
21. Moustafa MFH, Abdel-Fattah AFMA. Presumptive evidence of the effect of pregnancy estrogens on keloid growth: Case report. Plast Reconstr Surg. 1975;56:450.
22. Mouzas GL, Yeadon A. Does the choice of suture material affect the incidence of wound infection? A comparison of dexon (polyglycolic acid) sutures with other commonly used sutures in an accident and emergency department. Brit J Surg. 1975;62:952-955.
23. Sclafani AP, Gordon L, Chadha M, et al. Prevention of ear-lobe keloid recurrence with postoperative corticosteroid injection versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg. 1996;22:569-574.
24. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clinical Sci. 1998;94:557-572.
25. Hawkey CJ. Cox-2 Inhibitors. Lancet. 1999;353 (9149): 307-314.
26. Lee JI, Burckart GJ. Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharmacol. 1998;38:981-993.
27. Samuelsson B, Granstrom E, Green K, et al. Prostaglandins. Annu Rev Biochem. 1975;44:669-695.
28. McAdam BF, Mardini IA, Habib A, et al. Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest. 2000;105:1473-1482.
29. Capelli-Schellpfeffer M, Lee RC. Nonsteriodal antiinflammatory (NSAID) medication reduces scar pruritus. Proceedings of 3rd Meeting of European Tissue Repair Society. 1999; August: 63.
30. Topol BM, Lewis Jr VL, Benveniste K. The use of antihistamine to retard the growth of fibroblasts derived from human skin, scar, and keloid. Plast Reconstr Surg. 1981;68:227-232.
31. Cosman B. The antihistamine treatment of keloids. Plast Reconstr Surg. 1982;69:564-565.
32. Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surgery. 1999;25:224-232.
33. Crowston JG, Akbar AN, Constable PH, et al. Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci. 1998;39:449-454.
34. Ferguson MW. Skin wound-healing: transforming growth factor beta antagonists decrease scarring and improve quality. Journal of Interferon Research. 1994;14:303-304.
35. Larson DL, Abston S, Willis B, et al. Contracture and scar formation in the burn patient. Clin Plast Surg. 1974;1:653-656.
36. Kischer CW, Shetlar MR, Shetlar CL. Alteration of hypertrophic scars induced by mechanical pressure. Arch Dermatol. 1975;111:60-64.
37. Ahn ST, Monafo WW, Mustoe TA. Topical silicone gel: a new treatment for hypertrophic scars. Surgery. 1989;106:781-787.
38. Fulton JE. Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg. 1995;21:947-951.
39. Mercer NS. Silicone gel in the treatment of keloid scars. Brit J Plas Surg. 1989;42:83-87.
40. Musgrave MA, Umraw N, Fish JS, et al. The effect of silicone gel sheets on perfusion of hypertrophic burn scars. Journal of Burn Care & Rehabilitation. 2002;23:208-214.
41. Katz BE. Silicone gel sheeting in scar therapy. Cutis. 1995;56:65-67.
42. Krieger LM, Pan F, Doong H, et al. Thermal response of the epidermis to surface gels. Surgical Forum. 1993;738-740.
43. Ricketts CH, Martin L, Faria DT, et al. Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings. Dermatol Surg. 1996;22:955-959.
44. Phillips TJ, Gerstein AD, and Lordan V. A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids. Dermatol Surg. 1996;22:775-778.
45. Doong H, Dissanayake S, Gowrshankar TR, et al. Calcium antagonists alter cell shape and induce procollagenase synthesis in keloid and normal human dermal fibroblasts. J Burn Care & Rehab. 1996;17:497-514.
46. Varedi M, Tredget EE, Scott PG, et al. Alteration in cell morphology triggers transforming growth factor-B1, collagenase, and tissue inhibitor of metalloproteases-1 expression in normal and hypertrophic scar fibroblasts. J Invest Dermatol. 1995;104:118-123.
47. Lee RC, Doong H, Jellema A. The response of burn scars to intralesional verapamil. Arch Surg. 1994;129:107-111.
48. Hoffman S. Radiotherapy for keloids. Ann Plast Surg. 1982;9:265.
49. Norris JEC. Superficial X-ray therapy in keloid management: a retrospective study of 24 cases and literature review. Plast Reconstr Surg. 1995;95:1051-1055.
50. Watters D. Molecular mechanisms of ionizing radiation-induced apoptosis. Immunol Cell Biol. 1999;77:263-271.
51. Sherris DA, Larrabee WF. Management of scar contractures, hypertrophic scars and keloids. Otolaryngol Clin North Am. 1995;28:1057-1068.