Elevated levels of testosterone receptors in keloid tissue: An experimental investigation

Plastic and Reconstructive Surgery

Volumn 100, Issue 2, 1997, Pages 390-396

  Schierle, Hannes P ^a   Scholz, Dietmar ^b   Lemperle, Gottfried ^b  

^a Hals Nasen Ohrenheilkunde   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RECEPTOR PROTEIN; SEX HORMONE BINDING PROTEIN; TESTOSTERONE RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA DETERMINATION; FEMALE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; KELOID; MALE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; SKIN BIOPSY;

ADOLESCENT; ADULT; AGED; DNA; FEMALE; HUMANS; KELOID; MALE; MIDDLE AGED; RECEPTORS, ANDROGEN;

EID: 0030702946     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199708000-00017     Document Type: Article

References (16)

1. Muir, I. F. K. On the nature of keloid and hypertrophic scars. Br. J. Plast. Surg. 43: 61, 1990.
2. Geschickter, C. F., and Lewis, D. Tumors of connective tissue. Am. J. Cancer 25: 630, 1935.
3. Moustafa, M. F. H., and Abdel-Fattah, A. M. A. Presumptive evidence of the effect of pregnancy estrogens on keloid growth: A case report. Plast. Reconstr. Surg. 56: 450, 1975.
4. Ford, L. C., King, D. F., Lagasse, L. D., and Newcomer, V. Increased androgen binding in keloids: A preliminary communication. J. Dermatol. Surg. Oncol. 9: 545, 1983.
5. Price, V. H. Testosterone metabolism in the skin. Arch. Dermatol. 111: 1496, 1975.
6. Sansone, G., and Reisner, R. M. Differential rates of conversion of testosterone and dihydrotestosterone in acne and in normal human skin: A possible pathogenetic factor in acne. J. Invest. Dermatol. 56: 366, 1971.
7. Chase, R. A., and Schwartz, S. I. Skin and Subcutaneous Tissue. In S. I. Schwartz (Ed.), Principles of Surgery. New York: McGraw-Hill, 1969. P. 394.
8. Murray, J. C., Pollack, S. V., and Pinnell, S. R. Keloids and hypertrophic scars. Clin. Dermatol. 2: 121, 1984.
9. Keenan, B. S., Meyer, W. J., III, Hadjian, A. J., et al. Syndrome of androgen insensitivity in man: Absence of a 5-alpha-dihydrotestosterone binding protein in skin fibroblasts. J. Clin. Endocrinol. Metab. 38: 1143, 1974.
10. Oikarinen, A., Oikarinen, H., Meeker, C. A., Tan, E. M. L., and Uitto, J. Glucocorticoid receptors in cultured human skin fibroblasts: Evidence for down-regulation of receptor by glucocorticoid hormone. Acta Derm. Venereol. (Stockh.) 67: 461, 1987.
11. Diegelmann, R. F., Cohen, I. K., and McCoy, B. J. Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. J. Cell. Physiol. 98: 341, 1979.
12. Abergel, R. P., Pizzurro, D., Meeker, C. A., et al. Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol. 84: 384, 1985.
13. Uitto, J., Perejda, A. J., Abergel, R. P., et al. Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 82: 5935, 1985.
14. Burton, K. A. Study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62: 315, 1956.
15. Cockayne, D., Sterling, K. M., Jr., Shull, S., et al. Glucocorticoids decrease the synthesis of type I procollagen mRNAs. Biochemistry 25: 3202, 1986.
16. Scholz, D. Untersuchungen zur Ätiologie, Pathogenese und Histopathologie von Keloiden. Medical dissertation, Frankfurt, Germany, 1994.