Bridging Structural Biology and Genetics by Computational Methods: An Investigation into How the R774C Mutation in the AR Gene Can Result in Complete Androgen Insensitivity Syndrome

Human Mutation

Volumn 22, Issue 6, 2003, Pages 465-475

  Wu, Jian Hui ^a,b,c   Gottlieb, Bruce ^a,b,c   Batist, Gerald ^a,b,c   Sulea, Traian ^d   Purisima, Enrico O ^d   Beitel, Lenore K ^a   Trifiro, Mark ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Montreal Ctr Exp Therapeut Cancer   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

AIS; Androgen receptor; AR; Conformation analysis; Molecular dynamics simulations; Receptor ligand complex; Thermolabile

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GENE PRODUCT;

ANDROGEN INSENSITIVITY SYNDROME; ANDROGEN RECEPTOR GENE; ARTICLE; CASE REPORT; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; GENE MUTATION; GENE STRUCTURE; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR GENE; SIMULATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMAL ANALYSIS; THERMOSTABILITY;

ANDROGEN-INSENSITIVITY SYNDROME; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; COS CELLS; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; KINETICS; MALE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 0346993683     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.10279     Document Type: Article

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