Structural Insight into Modest Binding of a Non-PXXP Ligand to the Signal Transducing Adaptor Molecule-2 Src Homology 3 Domain

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48162-48168

  Kaneko, Tomonori ^a   Kumasaka, Takashi ^a   Ganbe, Tadashi ^a   Sato, Takao ^a   Miyazawa, Keiji ^b   Kitamura, Naomi ^a   Tanaka, Nobuo ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CRYSTAL STRUCTURE;

LIGANDS;

PROTEINS;

LIGAND; PEPTIDE; PROTEIN; SIGNAL TRANSDUCING ADAPTOR MOLECULE 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; EVOLUTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STRUCTURE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GLUTAMIC ACID; GRB2 ADAPTOR PROTEIN; KINETICS; LIGANDS; MICE; MODELS, MOLECULAR; PEPTIDES; PHENYLALANINE; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SPECTROMETRY, FLUORESCENCE; SRC HOMOLOGY DOMAINS;

EID: 0346850829     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306677200     Document Type: Article

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