-
1
-
-
50549159930
-
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations
-
Cleland, W. W. (1963) The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. Biochim. Biophys. Acta 67, 104-137
-
(1963)
Biochim. Biophys. Acta
, vol.67
, pp. 104-137
-
-
Cleland, W.W.1
-
2
-
-
50549188738
-
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: Nomenclature and theory
-
Cleland, W. W. (1963) The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory. Biochim. Biophys. Acta 67, 173-187
-
(1963)
Biochim. Biophys. Acta
, vol.67
, pp. 173-187
-
-
Cleland, W.W.1
-
3
-
-
50549155520
-
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection
-
Cleland, W. W. (1963) The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection. Biochim. Biophys. Acta 67, 188-196
-
(1963)
Biochim. Biophys. Acta
, vol.67
, pp. 188-196
-
-
Cleland, W.W.1
-
4
-
-
0014010187
-
Isotope exchange studies of the mechanism of the reaction catalyzed by adenosine triphosphate: Creatine phosphotransferase
-
Morrison, J. F., and Cleland, W. W. (1966) Isotope exchange studies of the mechanism of the reaction catalyzed by adenosine triphosphate: creatine phosphotransferase. J. Biol. Chem. 241, 673-683
-
(1966)
J. Biol. Chem.
, vol.241
, pp. 673-683
-
-
Morrison, J.F.1
Cleland, W.W.2
-
5
-
-
0014250413
-
Kinetic studies of Escherichia coli galactokinase
-
Gulbinsky, J. S., and Cleland, W. W. (1968) Kinetic studies of Escherichia coli galactokinase. Biochemistry 7, 566-575
-
(1968)
Biochemistry
, vol.7
, pp. 566-575
-
-
Gulbinsky, J.S.1
Cleland, W.W.2
-
6
-
-
0015219583
-
Kinetic and isotope-exchange studies on shikimate dehydrogenase from Pisum sativum
-
Balinsky, D., Dennis, A. W., and Cleland, W. W. (1971) Kinetic and isotope-exchange studies on shikimate dehydrogenase from Pisum sativum. Biochemistry 10, 1947-1952
-
(1971)
Biochemistry
, vol.10
, pp. 1947-1952
-
-
Balinsky, D.1
Dennis, A.W.2
Cleland, W.W.3
-
7
-
-
0015500405
-
Isotope exchange studies on liver alcohol dehydrogenase with cyclohexanol and cyclohexanone as reactants
-
Ainslie, G. R., Jr., and Cleland, W. W. (1972) Isotope exchange studies on liver alcohol dehydrogenase with cyclohexanol and cyclohexanone as reactants. J. Biol. Chem. 247, 946-951
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 946-951
-
-
Ainslie Jr., G.R.1
Cleland, W.W.2
-
8
-
-
0016220098
-
The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange
-
Uhr, M. L., Thompson, V. W., and Cleland, W. W. (1974) The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange. J. Biol. Chem. 249, 2920-2927
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 2920-2927
-
-
Uhr, M.L.1
Thompson, V.W.2
Cleland, W.W.3
-
9
-
-
0014473526
-
Kinetic studies of yeast nucleoside diphosphate kinase
-
Garces, E., and Cleland, W. W. (1969) Kinetic studies of yeast nucleoside diphosphate kinase. Biochemistry 8, 633-640
-
(1969)
Biochemistry
, vol.8
, pp. 633-640
-
-
Garces, E.1
Cleland, W.W.2
-
10
-
-
33947465376
-
Use of hydrogen isotope effects to identify the attacking nucleophile in the enolization of ketones catalyzed by acetic acid
-
Swain, C. G., Stivers, E. C., Reuwer, J. F., Jr., and Schaad, L. J. (1958) Use of hydrogen isotope effects to identify the attacking nucleophile in the enolization of ketones catalyzed by acetic acid. J. Am. Chem. Soc. 80, 5885-5893
-
(1958)
J. Am. Chem. Soc.
, vol.80
, pp. 5885-5893
-
-
Swain, C.G.1
Stivers, E.C.2
Reuwer Jr., J.F.3
Schaad, L.J.4
-
11
-
-
0016832598
-
Steady-state analysis of kinetic isotope effects in enzymic reactions
-
Northrop, D. B. (1975) Steady-state analysis of kinetic isotope effects in enzymic reactions. Biochemistry 14, 2644-2651
-
(1975)
Biochemistry
, vol.14
, pp. 2644-2651
-
-
Northrop, D.B.1
-
12
-
-
0009942589
-
-
University Park Press, Baltimore, MD
-
Cleland, W. W., O'Leary, M. H., and Northrop, D. B. (eds) (1977) Isotope Effects on Enzyme-catalyzed Reactions, pp. 280-283, University Park Press, Baltimore, MD
-
(1977)
Isotope Effects on Enzyme-Catalyzed Reactions
, pp. 280-283
-
-
Cleland, W.W.1
O'Leary, M.H.2
Northrop, D.B.3
-
13
-
-
0016809645
-
Equilibrium perturbation by isotope substitution
-
Schimerlik, M. I., Rife, J. E., and Cleland, W. W. (1975) Equilibrium perturbation by isotope substitution. Biochemistry 4, 5347-5354
-
(1975)
Biochemistry
, vol.4
, pp. 5347-5354
-
-
Schimerlik, M.I.1
Rife, J.E.2
Cleland, W.W.3
-
14
-
-
0018815070
-
Measurement of isotope effects by the equilibrium perturbation technique
-
Cleland, W. W. (1980) Measurement of isotope effects by the equilibrium perturbation technique. Methods Enzymol. 64, 104-125
-
(1980)
Methods Enzymol.
, vol.64
, pp. 104-125
-
-
Cleland, W.W.1
-
15
-
-
0020492976
-
Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase
-
Hermes, J. D., Roeske, C. A., O'Leary, M. H., and Cleland, W. W. (1982) Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase. Biochemistry 21, 5106-5114
-
(1982)
Biochemistry
, vol.21
, pp. 5106-5114
-
-
Hermes, J.D.1
Roeske, C.A.2
O'Leary, M.H.3
Cleland, W.W.4
-
16
-
-
0019194597
-
Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions
-
Cook, P. F., Blanchard, J. S., and Cleland, W. W. (1980) Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions. Biochemistry 21, 4853-4858
-
(1980)
Biochemistry
, vol.21
, pp. 4853-4858
-
-
Cook, P.F.1
Blanchard, J.S.2
Cleland, W.W.3
-
17
-
-
0017580411
-
Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies
-
Schimerlik, M. I., Grimshaw, C. E., and Cleland, W. W. (1977) Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies. Biochemistry 16, 571-576
-
(1977)
Biochemistry
, vol.16
, pp. 571-576
-
-
Schimerlik, M.I.1
Grimshaw, C.E.2
Cleland, W.W.3
-
18
-
-
0022423889
-
Use of intermediate partitioning to calculate intrinsic isotope effects for the reaction catalyzed by malic enzyme
-
Grissom, C. B., and Cleland, W. W. (1985) Use of intermediate partitioning to calculate intrinsic isotope effects for the reaction catalyzed by malic enzyme. Biochemistry 24, 944-948
-
(1985)
Biochemistry
, vol.24
, pp. 944-948
-
-
Grissom, C.B.1
Cleland, W.W.2
-
19
-
-
0009942589
-
-
University Park Press, Baltimore, MD
-
Cleland, W. W., O'Leary, M. H., and Northrop, D. B. (eds) (1977) Isotope Effects on Enzyme-catalyzed Reactions, pp. 280-283, University Park Press, Baltimore, MD
-
(1977)
Isotope Effects on Enzyme-Catalyzed Reactions
, pp. 280-283
-
-
Cleland, W.W.1
O'Leary, M.H.2
Northrop, D.B.3
-
20
-
-
0019157471
-
Use of isotope effects to deduce the chemical mechanism of fumarase
-
Blanchard, J. S., and Cleland, W. W. (1980) Use of isotope effects to deduce the chemical mechanism of fumarase. Biochemistry 19, 4506-4513
-
(1980)
Biochemistry
, vol.19
, pp. 4506-4513
-
-
Blanchard, J.S.1
Cleland, W.W.2
-
21
-
-
0019330801
-
Kinetic and chemical mechanisms of yeast formate dehydrogenase
-
Blanchard, J. S., and Cleland, W. W. (1980) Kinetic and chemical mechanisms of yeast formate dehydrogenase. Biochemistry 19, 3543-3550
-
(1980)
Biochemistry
, vol.19
, pp. 3543-3550
-
-
Blanchard, J.S.1
Cleland, W.W.2
-
22
-
-
0019891912
-
Mechanistic deductions from isotope effects in multireactant enzyme mechanisms
-
Cook, P. F., and Cleland, W. W. (1981) Mechanistic deductions from isotope effects in multireactant enzyme mechanisms. Biochemistry 20, 1790-1796
-
(1981)
Biochemistry
, vol.20
, pp. 1790-1796
-
-
Cook, P.F.1
Cleland, W.W.2
-
23
-
-
0019524346
-
pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope-and pH-dependent steps the same
-
Cook, P. F., and Cleland, W. W. (1981) pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope-and pH-dependent steps the same. Biochemistry 20, 1797-1805
-
(1981)
Biochemistry
, vol.20
, pp. 1797-1805
-
-
Cook, P.F.1
Cleland, W.W.2
-
24
-
-
0019472074
-
pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase
-
Cook, P. F., and Cleland, W. W. (1981) pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase. Biochemistry 20, 1805-1816
-
(1981)
Biochemistry
, vol.20
, pp. 1805-1816
-
-
Cook, P.F.1
Cleland, W.W.2
-
25
-
-
0020348401
-
Use of isotope effects to elucidate enzyme mechanisms
-
Cleland, W. W. (1982) Use of isotope effects to elucidate enzyme mechanisms. CRC Crit. Rev. Biochem. 13, 385-428
-
(1982)
CRC Crit. Rev. Biochem.
, vol.13
, pp. 385-428
-
-
Cleland, W.W.1
-
26
-
-
0008251476
-
Evidence from multiple isotope effect determinations for coupled hydrogen motion and tunneling in the reaction catalyzed by glucose-6-phosphate dehydrogenase
-
Hermes, J. D., and Cleland, W. W. (1984) Evidence from multiple isotope effect determinations for coupled hydrogen motion and tunneling in the reaction catalyzed by glucose-6-phosphate dehydrogenase. J. Am. Chem. Soc. 106, 7263-7264
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 7263-7264
-
-
Hermes, J.D.1
Cleland, W.W.2
-
27
-
-
0021756501
-
Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase
-
Hermes, J. D., Morrical, S. W., O'Leary, M. H., and Cleland, W. W. (1984) Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase. Biochemistry 23, 5479-5488
-
(1984)
Biochemistry
, vol.23
, pp. 5479-5488
-
-
Hermes, J.D.1
Morrical, S.W.2
O'Leary, M.H.3
Cleland, W.W.4
-
28
-
-
0021755240
-
Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase
-
Rendina, A. R., Hermes, J. D., and Cleland, W. W. (1984) Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase. Biochemistry 23, 6257-6262
-
(1984)
Biochemistry
, vol.23
, pp. 6257-6262
-
-
Rendina, A.R.1
Hermes, J.D.2
Cleland, W.W.3
-
29
-
-
0021755219
-
Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate
-
Hermes, J. D., Tipton, P. A., Fisher, M. A., O'Leary, M. H., Morrison, J. F., and Cleland, W. W. (1984) Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate. Biochemistry 23, 6263-6275
-
(1984)
Biochemistry
, vol.23
, pp. 6263-6275
-
-
Hermes, J.D.1
Tipton, P.A.2
Fisher, M.A.3
O'Leary, M.H.4
Morrison, J.F.5
Cleland, W.W.6
-
30
-
-
0022418788
-
Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine anmmonia-lyase
-
Hermes, J. D., Weiss, P. M., and Cleland, W. W. (1985) Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine anmmonia-lyase. Biochemistry 24, 2959-2967
-
(1985)
Biochemistry
, vol.24
, pp. 2959-2967
-
-
Hermes, J.D.1
Weiss, P.M.2
Cleland, W.W.3
-
31
-
-
0023658632
-
Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase
-
Weiss, P. M., Cook, P. F., Hermes, J. D., and Cleland, W. W. (1987) Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase. Biochemistry 26, 7378-7384
-
(1987)
Biochemistry
, vol.26
, pp. 7378-7384
-
-
Weiss, P.M.1
Cook, P.F.2
Hermes, J.D.3
Cleland, W.W.4
-
32
-
-
0034720690
-
15N kinetic isotope effects on the reaction of aspartate aminotransferase and the tyrosine-225 to phenylalanine mutant
-
15N kinetic isotope effects on the reaction of aspartate aminotransferase and the tyrosine-225 to phenylalanine mutant. Biochemistry 39, 7546-7551
-
(2000)
Biochemistry
, vol.39
, pp. 7546-7551
-
-
Rishavy, M.A.1
Cleland, W.W.2
-
33
-
-
33845559886
-
Heavy-atom isotope effects on the alkaline hydrolysis and hydrazinolysis of methyl benzoate
-
O'Leary, M. H., and Marlier, J. F. (1979) Heavy-atom isotope effects on the alkaline hydrolysis and hydrazinolysis of methyl benzoate. J. Am. Chem. Soc. 101, 3300-3306
-
(1979)
J. Am. Chem. Soc.
, vol.101
, pp. 3300-3306
-
-
O'Leary, M.H.1
Marlier, J.F.2
-
34
-
-
0029620544
-
Mechanisms of phosphoryl and acyl transfer
-
Cleland, W. W., and Hengge, A. C. (1995) Mechanisms of phosphoryl and acyl transfer. FASEB J. 9, 1585-1594
-
(1995)
FASEB J.
, vol.9
, pp. 1585-1594
-
-
Cleland, W.W.1
Hengge, A.C.2
-
35
-
-
0000144108
-
Concerted or stepwise mechanisms for acyl transfer reactions of p-nitrophenyl acetate? Transition state structures from isotope effects
-
Hengge, A. C., and Hess, R. A. (1994) Concerted or stepwise mechanisms for acyl transfer reactions of p-nitrophenyl acetate? Transition state structures from isotope effects. J. Am. Chem. Soc. 116, 11256-11263
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 11256-11263
-
-
Hengge, A.C.1
Hess, R.A.2
-
36
-
-
0032054709
-
Isotope effects on enzyme-catalyzed acyl transfer from p-nitrophenyl acetate: Concerted mechanisms and increased hyperconjugation in the transition state
-
Hess, R. A., Hengge, A. C., and Cleland, W. W. (1998) Isotope effects on enzyme-catalyzed acyl transfer from p-nitrophenyl acetate: concerted mechanisms and increased hyperconjugation in the transition state. J. Am. Chem. Soc. 120, 2703-2709
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 2703-2709
-
-
Hess, R.A.1
Hengge, A.C.2
Cleland, W.W.3
-
37
-
-
0026611633
-
13C isotope effects as a probe of the kinetic mechanism and allosteric properties of Escherichia coli aspartate transcarbamylase
-
13C isotope effects as a probe of the kinetic mechanism and allosteric properties of Escherichia coli aspartate transcarbamylase. Biochemistry 31, 6570-6576
-
(1992)
Biochemistry
, vol.31
, pp. 6570-6576
-
-
Parmentier, L.E.1
O'Leary, M.H.2
Schachman, H.K.3
Cleland, W.W.4
-
38
-
-
0026697117
-
Steady-state kinetics and isotope effects on the mutant catalytic trimer of aspartate transcarbamoylase containing the replacement of histidine 134 by alanine
-
Waldrop, G. L., Turnbull, J. L., Parmentier, L. E., O'Leary, M. H., Cleland, W. W., and Schachman, H. K. (1992) Steady-state kinetics and isotope effects on the mutant catalytic trimer of aspartate transcarbamoylase containing the replacement of histidine 134 by alanine. Biochemistry 31, 6585-6591
-
(1992)
Biochemistry
, vol.31
, pp. 6585-6591
-
-
Waldrop, G.L.1
Turnbull, J.L.2
Parmentier, L.E.3
O'Leary, M.H.4
Cleland, W.W.5
Schachman, H.K.6
-
39
-
-
0025837657
-
Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction
-
Weiss, P. M., Gavva, S. R., Harris, B. G., Urbauer, J. L., Cleland, W. W., and Cook, P. F. (1991) Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction. Biochemistry 30, 5755-5763
-
(1991)
Biochemistry
, vol.30
, pp. 5755-5763
-
-
Weiss, P.M.1
Gavva, S.R.2
Harris, B.G.3
Urbauer, J.L.4
Cleland, W.W.5
Cook, P.F.6
-
40
-
-
0031053278
-
Determination of the chemical mechanism of malic enzyme by isotope effects
-
Edens, W. A., Urbauer, J. L., and Cleland, W. W. (1997) Determination of the chemical mechanism of malic enzyme by isotope effects. Biochemistry 36, 1141-1147
-
(1997)
Biochemistry
, vol.36
, pp. 1141-1147
-
-
Edens, W.A.1
Urbauer, J.L.2
Cleland, W.W.3
-
41
-
-
0032559033
-
Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate
-
Urbauer, J. L., Bradshaw, D. E., and Cleland, W. W. (1998) Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate. Biochemistry 37, 18026-18031
-
(1998)
Biochemistry
, vol.37
, pp. 18026-18031
-
-
Urbauer, J.L.1
Bradshaw, D.E.2
Cleland, W.W.3
-
42
-
-
0034712585
-
13C and deuterium isotope effects suggest an aldol cleavage mechanism for L-ribulose-5-phosphate 4-epimerase
-
13C and deuterium isotope effects suggest an aldol cleavage mechanism for L-ribulose-5-phosphate 4-epimerase. Biochemistry 39, 4808-4820
-
(2000)
Biochemistry
, vol.39
, pp. 4808-4820
-
-
Lee, L.V.1
Vu, M.V.2
Cleland, W.W.3
-
43
-
-
0347785486
-
Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis
-
Reinhardt, L. A., Svedruzic, D., Chang, C. H., Cleland, W. W., and Richards, N. G. J. (2003) Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis. J. Am. Chem. Soc. 125, 1244-1252
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 1244-1252
-
-
Reinhardt, L.A.1
Svedruzic, D.2
Chang, C.H.3
Cleland, W.W.4
Richards, N.G.J.5
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