Determination of the kinetic and chemical mechanism of malic enzyme using (2R,3R)-erythro-fluoromalate as a slow alternate substrate

Biochemistry

Volumn 37, Issue 51, 1998, Pages 18026-18031

  Urbauer, Jeffrey L ^a,c   Bradshaw, Debra E ^a   Cleland, W W ^a,b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b University of Pennsylvania ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETYLPYRIDINE; 3 ACETYLPYRIDINE NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; FLUOROMALIC ACID; MALATE DEHYDROGENASE (DECARBOXYLATING); MALIC ACID DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION KINETICS; CHICKEN; CONJUGATION; DECARBOXYLATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; REACTION ANALYSIS;

ANIMALS; CARBON ISOTOPES; CATALYSIS; CATTLE; CHICKENS; COENZYMES; DECARBOXYLATION; DEUTERIUM; KINETICS; MALATE DEHYDROGENASE; MALATES; NAD; NADP; OXALOACETATES; RABBITS; SUBSTRATE SPECIFICITY; SWINE;

EID: 0032559033     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981820f     Document Type: Article

References (14)

1. Ochoa, S., Mehler, A. H., and Kornberg, A. (1947) J. Biol. Chem. 167, 871-872.
2. Hermes, J. D., Roeske, C. A., O'Leary, M. H., and Cleland, W. W. (1982) Biochemistry 21, 5106-5114.
3. Grissom, C. B., and Cleland, W. W. (1985) Biochemistry 24, 944-948.
4. Urbauer, J. L., and Cleland, W. W. (1989) J. Cell Biol. 107, 401a.
5. Weiss, P. M., Gavva, S. R., Harris, B. G., Urbauer, J. L., Cleland, W. W., and Cook, P. F. (1991) Biochemistry 30, 5755-5763.
6. Karsten, W. E., and Cook, P. F. (1994) Biochemistry 33, 2096-2103.
7. Edens, W. A., Urbauer, J. L., and Cleland, W. W. (1997) Biochemistry 36, 1141-1147.
8. Cook, P. F., and Cleland, W. W. (1981) Biochemistry 20, 1790-1796.
9. Urbauer, J. L., Bradshaw, D. E., and Cleland, W. W. (1998) Biochemistry 37, xxxx-xxxx.
10. Grissom, C. B., and Cleland, W. W. (1988) Biochemistry 27, 2927-2934.
11. Park, S.-H., Kiick, D. M., Harris, B. G., and Cook, P. F. (1984) Biochemistry 23, 5446-5453.
12. Grissom, C. B., and Cleland, W. W. (1986) J. Am. Chem. Soc. 108, 5582-5583.
13. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
14. Dummel, R. J., Berry, M. N., and Kun, E. (1971) Mol. Pharmacol. 7, 367-374.