Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation

Journal of Leukocyte Biology

Volumn 74, Issue 5, 2003, Pages 857-867

  Oliveira, M A P ^a,c   Lima, G M A C ^a   Shio, M T ^a   Leenen, P J M ^b   Abrahamsohn, I A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

GM CSF; IL 12; IL 3; M CSF; Monocyte macrophage differentiation; Nitric oxide

Indexed keywords

CD11B ANTIGEN; CD31 ANTIGEN; CELL MARKER; COLONY STIMULATING FACTOR 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 3; LIPOPOLYSACCHARIDE; NITRIC OXIDE; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; BONE MARROW CELL; CELL ACTIVITY; CELL DENSITY; CELL MATURATION; CELL POPULATION; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPARATION TECHNIQUE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL SEPARATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-3; LIPOPOLYSACCHARIDES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MONOCYTES; NITRIC OXIDE; PROTEIN SUBUNITS;

ANIMALIA;

EID: 0346731247     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb0302124     Document Type: Conference Paper

References (61)

1. Trinchieri, G. (1998) Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70, 83-243.
2. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A. S., Adorini, L., Gubler, U., Presky, D. H. (1998) The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16, 495-521.
3. Faquim-Mauro, E. L., Coffman, R. L., Abrahamsohn, J. A., Macedo, M. S. (1999) Cutting edge: mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12. J. Immunol. 163, 3572-3576.
4. D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176, 1387-1398.
5. Cassatella, M. A., Meda, L., Gasperini, S., D'Andrea, A., Ma, X., Trinchieri, G. (1995) Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25, 1-5.
6. Macatonia, S. E., Hosken, N. A., Litton, M., Vieira, P., Hsieh, C. S., Culpepper, J. A., Wysocka, M., Trinchieri, G., Murphy, K. M., O'Carra, A. (1995) Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154, 5071-5079.
7. Liu, Y. J., Kanzler, H., Soumelis, V., Gilliet, M. (2001) Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2, 585-589.
8. Ardavin, C., Martinez del Hoyo, G., Martin, P., Anjuere, F., Arias, C. F., Marin, A. R., Ruiz, S., Parrillas, V., Hernandez, H. (2001) Origin and differentiation of dendritic cells. Trends Immunol. 22, 691-700.
9. Hart, D. N. (1997) Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90, 3245-3287.
10. Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R., Liu, Y. J. (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186.
11. Kalinski, P., Schuitemaker, J. H., Hilkens, C. M., Wierenga, E. A., Kapsenberg, M. L. (1999) Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J. Immunol. 162, 3231-3236.
12. Ebner, S., Ratzinger, G., Krosbacher, B., Schmuth, M., Weiss, A., Reider, D., Kroczek, W. A., Herold, M., Heufler, C., Fritsch, P., et al. (2001) Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4. J. Immunol. 166, 633-641.
13. Turpin, J. A., Lopez-Berestein, G. (1992) Differentiation, maturation, and activation of monocytes and macrophages: functional a activity is controlled by a continnum of maturation. In Mononuclear Phagocytes in Cell Biology (G. Lopez-Berestein and K. J., eds), CRC Press, Boca Raton 71-99.
14. Leenen, P. J., de Bruijn, M. F., Voerman, J. S., Campbell, P. A., van Ewijk, W. (1994) Markers of mouse macrophage development of detected by monoclonal antibodies. J. Immunol. Methods 174, 5-19.
15. Askew, D., Gatewoud, J., Olivas, E., Havenith, K., Walker, W. S. (1995) A subset of macrophages process and present native antigen to naive antigen-specific CD4+ T-cells from juice transgenic for an alpha beta T-cell receptor. Cell. Immunol. 166, 62-70.
16. Chan, J., Leenen, P. J., Bertoncello, I., Nishikawa, S. I., Hamilton, J. A. (1998) Macrophage lineage cells in inflammation: characterization by colony-stimulating factor-1 (CSF-1) receptor (c-Fms), ER-MP58, and ER-MP20 (Ly-6C) expression. Blood 92, 1423-1431.
17. Elias, J. A., Schreiber, A. D., Gustilo, K., Chien, P., Rossman, M. D., Lammie, P. J., Daniele, R. P. (1985) Differential interleukin 1 elaboration by unfractionated and density fractionated human alveolar macrophages and blood monocytes: relationship to cell maturity. J. Immunol. 135, 3198-3204.
18. Angulo, I., Bullas, J., Campillo, J. A., Obregon, E., Heath, A., Howard, M., Munoz-Fernandez, M. A., Subiza, J. L. (2000) Early myeloid cells are high producers of nitric oxide upon CD40 plus IFN-gamma stimulation through a mechanism dependent on endogenous TNF-alpha and IL-1alpha. Eur. J. Immunol. 30, 1263-1271.
19. Sousa, C. R., Heiny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R. N., Sher, A. (1997) In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186, 1819-1829.
20. Smith, W., Feldmann, M., Londei, M. (1998) Human macrophage in duced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production. Eur. J. Immunol. 28, 2498-2507.
21. Doherty, T. M., Coffman, R. L. (1993) Leishmania antigens presented by GM-CSF-derived macrophage protect susceptible mice against challenge with Leishmania major. J. Immunol. 150, 5476-5483.
22. Biermann, H., Pietz, B., Dreier, R., Schmid, K. W., Sorg, C., Sunderkotter, C. (1999) Murine leukocytes with ring-shaped nuclei include granulocytes, monocytes, and their precursors. J. Leukoc. Biol. 65, 217-231.
23. Pinge-Filho, P., Tadokoro, C. E., Abrahamsohn, I. A. (1999) Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. Cell. Immunol. 193, 90-98.
24. Kennedy, D. W., Abkowitz, J. L. (1998) Mature monocytic cells enter tissues and engraft. Proc. Natl. Acad. Sci. USA 95, 14944-14949
25. Leenen, P. J., Radosevic, K., Voerman, J. S., Salomon, B., van Rooijen, N., Klatzmann, D., van Ewijk, W. (1998) Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J. Immunol. 160, 2166-2173.
26. McKnight, A. J., Gordon, S. (1998) Membrane molecules as differentiation antigens of murine macrophages. Am. Immunol. 68, 271-314.
27. de Bruijn, M. F., van Vianen, W., Ploemacher, R. E., Bakker-Woudenberg, I. A., Campbell, P. A., van Ewijk, W., Leenen, P. J. (1998) Bone marrow cellular composition in listeria monocytogenes infected mice detected using ER-MP12 and ER-MP20 antibodies: a flow cytometric alternative to differential counting. J. Immunol. Methods 217, 27-39.
28. Huang, F. P., Niedbala, W., Wei, X. Q., Xu, D., Feng, G. J., Robinson, J. H., Lam, C., Liew, F. Y. (1998) Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol. 28, 4062-4070.
29. Ma, X., Sun, J., Papasavvas, E., Riemann, H., Robertson, S., Marshall, J., Bailer, R. T., Moore, A., Donnelly, R. P., Trinchieri, G., et al. (2000) Inhibition of IL-12 production in human monocyte-derived macrophages by TNF. J. Immunol. 164, 1722-1729.
30. Stanley, E. R., Heard, P. M. (1977) Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L. cells. J. Biol. Chem. 252, 4305-4312.
31. Tushinski, R. J., Oliver, I. T., Guilbert, L. J., Tynan, P. W., Warner, J. R., Stanley, E. R. (1982) Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28, 71-81.
32. Englen, M. D., Valdez, Y. E., Lehnert, N. M., Lehnert, B. E. (1995) Granulocyte/macrophage colony-stimulating factor is expressed and secreted in cultures of murine L929 cells. J. Immunol. Methods 184, 281-283.
33. Baumeister, T., Rossner, S., Pech, G., de Bruijn, M. F. T. R., Leenen, P. J. M., Schuler, G., Lutz, M. B. (2003) IL-3R alpha+ myeloid dendritic cells and mass cells develop simultaneously from different bone marrow precursors in cultures with IL-3. J. Invest. Dermatol., In press.
34. Grage-Griebenow, E., Flad, H. D., Ernst, M. (2001) Heterogeneity of human peripheral blood monocyte subsets. J. Leukoc. Biol. 69, 11-20.
35. Auger, M. J., Ross, J. A. (1992) The biology of the macrophage. In The Macrophage (C. E. Lewis and J. O. McGee, eds), Oxford: IRL Press, Oxford 2-71.
36. Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., Ozato, K. (2000) ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13, 155-165.
37. Walker, E. B., Akporiaye, E. T., Warner, N. L., Stewart, C. C. (1985) Characterization of subsets of bone marrow-derived macrophages by flow cytometry analysis. J. Leukoc. Biol. 37, 121-136.
38. Gazzinelli, R. T., Talvani, A., Camargo, M. M., Santiago, H. C., Oliveira, M. A., Vieira, L. Q., Martins, G. A., Aliberti, J. C., Silva, J. S. (1998) Induction of cell-mediated immunity during early stages of infection with intracellular protozoa. Braz. J. Med. Biol. Res. 31, 89-104.
39. Bogdan, C., Rollinghoff, M., Diefenbach, A. (2000) Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr. Opin. Immunol. 12, 64-76.
40. Piccotti, J. R., Chan, S. Y., Li, K., Eichwald, E. J., Bishop, D. K. (1997) Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells. J. Immunol. 158, 643-648.
41. Mattner, F., Ozmen, L., Podlaski, F. J., Wilkinson, V. L., Presky, D. H., Gately, M. K., Alber, G. (1997) Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect. Immun. 65, 4734-4737.
42. Heinzel, F. P., Hujer, A. M., Ahmed, F. N., Rerko, R. M. (1997) In vivo production and function of IL-12 p40 homodimers. J. Immunol. 158, 4381-4388.
43. Karp, C. L., Wysocka, M., Ma, X., Marovich, M., Factor, R. E., Nutman, T., Armant, M., Wahl, L., Cuomo, P., Trinchieri, G. (1998) Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur. J. Immunol. 28, 3128-3136.
44. Hayes, M. P., Wang, J., Norcross, M. A. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferongamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86, 646-650.
45. Sartori, A., Oliveira, M. A., Scott, P., Trinchieri, G. (1997) Metacyelogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells. J. Immunol. 159, 2849-2857.
46. Sweet, M. J., Campbell, C. C., Sester, D. P., Xu, D., McDonald, R. C., Stacey, K. J., Hume, D. A., Liew, F. Y. (2002) Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J. Immunol. 168, 392-399.
47. Hilkens, C. M., Kalinski, P., de Boer, M., Kapsenberg, M. L. (1997) Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 90, 1920-1926.
48. Snijders, A., Kalinski, P., Hilkens, C. M., Kapsenberg, M. L. (1998) High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10, 1593-1598.
49. Wesa, A. K., Galy, A. (2001) IL-1 beta induces dendritic cells to produce IL-12. Int. Immunol. 13, 1053-1061.
50. Kalinski, P., Vieira, P. L., Schuitemaker, J. H., de Jong, E. C., Kapsenberg, M. L. (2001) Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood 97, 3466-3469.
51. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., et al. (2000) Novel p19 protein engages IL-12p40 to forms cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725.
52. Park, A. Y., Scott, P. (2001) IL-12: keeping cell-mediated immunity alive. Scand. J. Immunol. 53, 529-532.
53. Beeker, C., Wirtz, S., Ma, X., Blessing, M., Galle, P. R., Neurath, M. F. (2001) Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2). J. Immunol. 167, 2608-2618.
54. D'Andrea, A., Ma. X., Aste-Amezaga, M., Paganin, C., Trinchieri, G. (1995) Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J. Exp. Med. 181, 537-546.
55. Du, C., Sriram, S. (1998) Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells. J. Leukoc. Biol. 64, 92-97.
56. Diefenhach, A., Schindler, H., Donhauser, N., Lorenz, E., Laskay, T., MacMicking, J., Rollinghoff, M., Gresser, I., Bogdan, C. (1998) Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8, 77-87.
57. Rothe, H., Hartmann, B., Geerlings, P., Kolb, H. (1996) Interleukin-12 gene-expression of macrophages is regulated by nitric oxide. Biochem. Biophys. Res. Commun. 224, 159-163.
58. Mullins, D. W., Burger, C. J., Elgert, K. D. (1999) Paclitaxel enhances macrophage IL-12 production in tumor-bearing hosts through nitric oxide. J. Immunol. 162, 6811-6818.
59. Hodge-Dufour, J., Marino, M. W., Horton, M. R., Jungbluth, A., Burdick, M. D., Strieter, R. M., Noble, P. W., Hunter, C. A., Pure, E. (1998) Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism film the anti-inflammatory activities of tumor necrosis factor. Proc. Natl. Acad. Sci. USA 95, 13806-13811.
60. Flesch, I. E., Hess, J. H., Huang, S., Aguet, M., Rothe, J., Bloethmann, H., Kaufmann, S. H. (1995) Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J. Eur. Med. 181, 1615-1621.
61. Zhan, Y., Cheers, C. (1998) Control of IL-12 and IFN-gamma production in response to live or dead bacteria by TNF and other factors. J. Immunol. 161, 1447-1453.