Characterization of Recombinant Microsporidian Methionine Aminopeptidase Type 2

Journal of Eukaryotic Microbiology

Volumn 50, Issue SUPPL., 2003, Pages 597-599

  Weiss, Louis M ^a   Zhou, Guo Chun ^a   Zhang, Hong ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; METALLOPROTEINASE; METHIONINE AMINOPEPTIDASE 2; PRIMER DNA; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

MICROBIOLOGY;

ANIMAL; CELL LINE; CHEMISTRY; CONFERENCE PAPER; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; MICROSPORIDA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTOZOAN SPORE;

AMINOPEPTIDASES; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; METALLOENDOPEPTIDASES; MICROSPORIDIA; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SPORES, PROTOZOAN;

ANIMALIA; MICROSPORIDIA; PROTOZOA;

EID: 0346336172     PISSN: 10665234     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2003.tb00643.x     Document Type: Conference Paper

References (26)

1. 1. Bontems, F., le Flocli, P., Duffieux, F., Biderre, C., Peyret, P. & Lallemund, J.Y. 2003. Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design. Biophys Chem., 105:29-43.
2. Costa, S.F. & Weiss, L.M. 2000. Drug treatment of microsporidiosis. Drug Resist. Updates, 3:384-399.
3. Coyle, C., Kent, M., Tanowitz, H.B., Wittner, M. & Weiss, L.M. 1998. TNP-470 is an effective anti-microsporidial agent. J. Infect. Dis., 177:515-518.
4. Chang, Y.H., Teichert, U. & Smith, J.A. 1990. Purification and characterization of a methionine aminopeptidase from Saccharomyces cervisiae. J. Biol. Sci. 265:19892-19897.
5. Griffith, E.C., Su, Z., Turk. B.E., Chen, S., Chang, Y.H., Wu, Z., Biemann, K. & Liu, J.O. 1997. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Client. Biol., 4:461-471.
6. Han, C.K., Ahn, S.K., Choi, N.S., Hong, R.K., Moon, S.K., Chun, H.S., Lee, S.J., Kim, J.W., Hong, C.I., Kim, D., Yoon, J.H. & No, K.T. 2000. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP2. Bioorgan. Med. Chem. Lett., 10:39-43.
7. Higgins. M.J., Kent, M.L., Noran, J.D. & Weiss, L.M. 1998. Efficacy of the fumagillin analog TNP-470 for Nucleospora salmonis and Loma salmonae infections in chinook salmon (Oncorhynchus tshawytscah). Dis. Aquat. Org., 34:45-49.
8. Katinka, M.D., Duprat, S., Cornillo, E., Metenier, G., Thomarat, F, Prensier, G., Barve, V., Peyretaillade, E., Brottier, P, Wincker, P, Delbac, F. Alaoui, H.E., Peyret. P, Saurin, W., Gouy, M., Weissenbach, J. & Vivares, C.P. 2001. Genome sequence and gene compaction of the eukaryotic parasite Encephalitozoon cuniculi. Nature, 184:29-42.
9. Keohane, E.M., Orr, G.A., Zhang. H.S., Takvorian, P.M., Cali, A., Tanowitz, H.B., Wittner, M. & Weiss, L.M. 1998. The molecular characterization of the major polar tube gene from Encephalitozoon hellem, a microsporidian parasite of humans. Mol. Biochem. Parasitol., 94:227-236.
10. Li, X. & Chang, Y.H. 1995. Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases. Proc. Natl. Acad. Sci. USA. 92:12357-12361.
11. Liu. S., Widom. J., Kemp, C.W., Crews, C.M. & Clardy, J. 1998. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282:1324-1327.
12. Luo, Q.L., Li, J.Y., Liu, Z.Y., Chen, L.L., Li, J., Qian, Z., Shen, Q., Li, Y., Lushington, G.H., Ye, Q.Z. & Nan, F.J. 2003. Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cevevisiae. J. Med. Chem., 46: 2631-2640.
13. Molina, J.M., Tourneur, M., Sarfati, C., Chevret, S., de Gouvello, A., Gobert, J.G., Balkan, S., Derouin, F. & Agence Nationale de Recherches sur le SIDA 090 Study Group. 2002. Fumagillin treatment of intestinal microsporidiosis. N. Engl. J. Med., 346:1963-1969.
14. Rosenberger, D.F., Serdarevic, O.N., Erlandson, R.A., Bryan R.T., Schwartz, D.A., Visvesvara, G.S. & Keenan, P.C. 1993. Successful treatment of microsporidial keratoconjunctivitis with topical fumagillin in a patient with AIDS. Cornea, 12:261-265.
15. Sali, A. & Blundell, T.L. 1993. Comparative protein modeling by satisfaction of spatial restraints. J. Mol. Biol., 234:779-815.
16. Sali, A. & Overington, J.P. 1994. Derivation of rules for comparative protein modeling from a database of protein structure alignments. Protein Sci., 3:1582-1596.
17. Shadduck, J.A. 1980. Effect of fumagillin on in vitro multiplication of Encephalitozoon cuniculi. J. Protozool., 27:202-208.
18. Sin, N., Meng, L., Wang, M.Q.W., Wen, J.J., Bornmann, W.G. & Crews. C.M. 1997. The anti-angiogeneic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc. Natl. Acad. Sci. USA, 94:6099-6103.
19. Taylor, A. 1993. Aminopeptidases: structure and function. FASEB J.???. 7:290-298.
20. Wang, J., Sheppard, G.S., Lou, P., Kawai, M., Park, C., Egan, D.A., Schneider, A., Bouska, J., Lesniewski, R. & Henkin, J. 2003. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. Biochemistry, 42:5035-5042.
21. Wittner, M. & Weiss, L.M. (ed.). 1999. The Microsporidia and Microsporidiosis. ASM Press, Washington DC.
22. Weiss, L.M., Costa, S.F. & Zhang, H. 2001. Microsporidian methionine aminopeptidase type 2. J. Eukaryot. Microbiol., 48:88S-90S.
23. Weiss, L.M., Edlind, T.D., Vossbrinck, C.R. & Hashimoto, T. 1999. Microsporidian molecular phylogeny: the fungal connection. J. Eukaryot. Microbiol., 46:17S-18S.
24. Weiss, L.M., Michalakakis, E., Coyle, C.M., Tanowitz, H.B. & Wittner, M. 1994. The activity of albendazole against Encephalitozoon cuniculi. J. Eukaryot. Microbiol., 41:65S.
25. Weiss, L.M. & Vossbrinck, C.R. 1998. Microsporidiosis: molecular and diagnostic aspects. Adv. Parasitol., 40:352-395.
26. Zhou, Y., Guo, X.C., Yi, T., Yoshimoto, T. & Pei, D. 2000. Two continuous spectrophotometric assays for methionine aminopeptidase. Anal. Biochem., 280:159-65.