TNP-470 is an effective antimicrosporidial agent

Journal of Infectious Diseases

Volumn 177, Issue 2, 1998, Pages 515-518

  Coyle, Christina ^b   Kent, Michael ^b   Tanowitz, Herbert B ^b   Wittner, Murray ^b   Weiss, Louis M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; FUMAGILLIN; FUMAGILLOL CHLOROACETYLCARBAMATE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL MODEL; MICROSPORA; MICROSPORIDIOSIS; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SURVIVAL; WASTING SYNDROME;

EID: 0031929734     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517390     Document Type: Article

References (16)

1. Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev 1996;7:426-61.
2. Orenstein JM. Microsporidiosis. In: Connor DH, Chandler FW, Schwartz DA, Manz HJ, Lack EE, eds. Pathology of infectious diseases. Vol 2. Stamford, CT: Appleton & Lange, 1997:1223-40.
3. Molina JM, Oksenhendler E, Beauvais B, et al. Disseminated microsporidosis due to Septata intestinalis in patients with AIDS: clinical features and response to albendazole therapy. J Infect Dis 1995;171:245-9.
4. Dieterich DT, Lew EA, Kotler DP, Poles MA, Orenstein JM. Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS. J Infect Dis 1994;169:1789-93.
5. Ketznelson H, Jamieson CA. Control of Nosema disease of honey bees with fumagillin. Science 1952;115:70-1.
6. Shadduck JA. Effect of fumagillin on in vitro multiplication of Encephalitozoon cuniculi. J Protozool 1980;27:202-8.
7. Diesenhouse MC, Wilson LA, Corrent GF, Visvesvara GS, Grossniklaus HE, Bryan RT. Treatment of microsporidial keratoconjunctivitis with topical fumagillin. Am J Ophthalmol 1993;115:293-8.
8. Ingber D, Fujita T, Kishimoto S, et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 1990;348:555-7.
9. Weiss LM, Cali A, Levee E, et al. Diagnosis of Encephalitozoon cuniculi infection by Western blot and the use of cross-reactive antigens for the possible detection of microsporidiosis in humans. Am J Trop Med Hyg 1992;46:456-62.
10. Didier ES, Varner PW, Didier PJ, et al. Experimental microsporidiosis in immunocompetent and immunodeficient mice and monkeys. Folia Parasitol (Praha) 1994;41:1-11.
11. Didier ES. Effects of albendazole, fumagillin, and TNP-470 and microsporidial replication in vitro. Antimicrob Agents Chemother 1997;41:1541-6.
12. Yanase T, Masaki T, Kazuyuki F, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993;53:2566-70.
13. Molina JM, Goguel J, Sarfati C, et al. Drug screening for the treatment of Enterocytozoon bieneusi infections in patients with HIV Infection (ANRS 034) [abstract 687]. In: 4th Conference on Retroviruses and Opportunistic Infections: program and abstracts (Washington, DC). Alexandria, VA: Infectious Diseases Society of America, 1997:191.
14. Chilmonczyk S, Cox WT, Hendrick RP. Enterocytozoon salmonis N.Sp.: an intranuclear microsporidium from salmonid fish. J Protozool 1991;38:264-9.
15. Hendrick RP, Groff JM, Baxa DV. Experimental infections with Enterocytozoon salmonis Chilmonczyk, Cox, Hedrick (Microsporea): an intranuclear microsporidium from chinook salmon Oncorhynchus tshawytscha. Dis Aquatic Org 1991;10:103-8.
16. Eaton WD, Kent ML. A retrovirus in chinook salmon (Oncorhynchus tshawytscha) with plasmocytoid leukemia and evidence for the etiology of the disease. Cancer Res 1992;52:6496-500.