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Volumn 15, Issue 6, 2003, Pages 643-653

Kit/stem cell factor receptor-induced phosphatidylinositol 3′-kinase signalling is not required for normal development and function of interstitial cells of Cajal in mouse gastrointestinal tract

Author keywords

Enteric nervous system; Gastrointestinal motility; Proto oncogene protein c Kit; Receptor protein tyrosine kinases; Stem cell factor

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; STEM CELL FACTOR RECEPTOR;

EID: 0346334661     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1350-1925.2003.00448.x     Document Type: Article
Times cited : (15)

References (43)
  • 1
    • 0031850686 scopus 로고    scopus 로고
    • Interstitial cells of Cajal generate a rhythmic pacemaker current
    • Thomsen L, Robinson TL, Lee JC et al. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med 1998; 4: 848-51.
    • (1998) Nat Med , vol.4 , pp. 848-851
    • Thomsen, L.1    Robinson, T.L.2    Lee, J.C.3
  • 3
    • 0027967089 scopus 로고
    • Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine
    • Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 1994; 480(Pt 1): 91-97.
    • (1994) J Physiol , vol.480 , Issue.1 PART , pp. 91-97
    • Ward, S.M.1    Burns, A.J.2    Torihashi, S.3    Sanders, K.M.4
  • 4
  • 6
    • 0034652345 scopus 로고    scopus 로고
    • Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons
    • Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20: 1393-403.
    • (2000) J Neurosci , vol.20 , pp. 1393-1403
    • Ward, S.M.1    Beckett, E.A.2    Wang, X.3    Baker, F.4    Khoyi, M.5    Sanders, K.M.6
  • 7
    • 0033965335 scopus 로고    scopus 로고
    • Decreased interstitial cell of cajal volume in patients with slow-transit constipation
    • He CL, Burgart L, Wang L et al. Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology 2000; 118: 14-21.
    • (2000) Gastroenterology , vol.118 , pp. 14-21
    • He, C.L.1    Burgart, L.2    Wang, L.3
  • 8
    • 0036785361 scopus 로고    scopus 로고
    • Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation
    • Lyford GL, He CL, Soffer E et al. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 2002; 51: 496-501.
    • (2002) Gut , vol.51 , pp. 496-501
    • Lyford, G.L.1    He, C.L.2    Soffer, E.3
  • 10
    • 0029101721 scopus 로고
    • Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats
    • Isozaki K, Hirota S, Nakama A et al. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Gastroenterology 1995; 109: 456-64.
    • (1995) Gastroenterology , vol.109 , pp. 456-464
    • Isozaki, K.1    Hirota, S.2    Nakama, A.3
  • 11
    • 0031963591 scopus 로고    scopus 로고
    • Action potential generation, Kit receptor immunohistochemistry and morphology of steel-Dickie (Sl/Sld) mutant mouse small intestine
    • Mikkelsen HB, Malysz J, Huizinga JD, Thuneberg L. Action potential generation, Kit receptor immunohistochemistry and morphology of steel-Dickie (Sl/Sld) mutant mouse small intestine. Neurogastroenterol Motil 1998; 10: 11-26.
    • (1998) Neurogastroenterol Motil , vol.10 , pp. 11-26
    • Mikkelsen, H.B.1    Malysz, J.2    Huizinga, J.D.3    Thuneberg, L.4
  • 12
    • 0029200069 scopus 로고
    • Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants
    • Ward SM, Burns AJ, Torihashi S, Harney SC, Sanders KM. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 1995; 269(6 Pt 1): C1577-85.
    • (1995) Am J Physiol , vol.269 , Issue.6 PART 1
    • Ward, S.M.1    Burns, A.J.2    Torihashi, S.3    Harney, S.C.4    Sanders, K.M.5
  • 13
    • 0027965243 scopus 로고
    • Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
    • Blume-Jensen P, Ronnstrand L, Gout I, Waterfield MD, Heldin CH. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. J Biol Chem 1994; 269: 21793-802.
    • (1994) J Biol Chem , vol.269 , pp. 21793-21802
    • Blume-Jensen, P.1    Ronnstrand, L.2    Gout, I.3    Waterfield, M.D.4    Heldin, C.H.5
  • 14
    • 0025812785 scopus 로고
    • Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase
    • Reith AD, Ellis C, Lyman SD et al. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J 1991; 10: 2451-9.
    • (1991) EMBO J , vol.10 , pp. 2451-2459
    • Reith, A.D.1    Ellis, C.2    Lyman, S.D.3
  • 15
    • 0025891543 scopus 로고
    • The Steel/W transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
    • Rottapel R, Reedijk M, Williams DE et al. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol 1991; 11: 3043-51.
    • (1991) Mol Cell Biol , vol.11 , pp. 3043-3051
    • Rottapel, R.1    Reedijk, M.2    Williams, D.E.3
  • 16
    • 0027280226 scopus 로고
    • Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand
    • Yi T, Ihle JN. Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol 1993; 13: 3350-8.
    • (1993) Mol Cell Biol , vol.13 , pp. 3350-3358
    • Yi, T.1    Ihle, J.N.2
  • 17
    • 0032828882 scopus 로고    scopus 로고
    • Early signaling pathways activated by c-Kit in hematopoietic cells
    • Linnekin D. Early signaling pathways activated by c-Kit in hematopoietic cells. Int J Biochem Cell Biol 1999; 31: 1053-74.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 1053-1074
    • Linnekin, D.1
  • 18
    • 0033136004 scopus 로고    scopus 로고
    • Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle
    • Ward SM, Brennan MF, Jackson VM, Sanders KM. Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle. J Physiol 1999; 516(Pt 3): 835-46.
    • (1999) J Physiol , vol.516 , Issue.3 PT , pp. 835-846
    • Ward, S.M.1    Brennan, M.F.2    Jackson, V.M.3    Sanders, K.M.4
  • 19
    • 0029831167 scopus 로고    scopus 로고
    • Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
    • Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC Jr, Abraham RT. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. Embo J 1996; 15: 5256-457.
    • (1996) Embo J , vol.15 , pp. 5256-5457
    • Brunn, G.J.1    Williams, J.2    Sabers, C.3    Wiederrecht, G.4    Lawrence Jr., J.C.5    Abraham, R.T.6
  • 20
    • 0028128692 scopus 로고
    • Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit- Associated PI 3-kinase activity in COS-1 cells
    • Serve H, Hsu YC, Besmer P. Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells. J Biol Chem 1994; 269: 6026-50.
    • (1994) J Biol Chem , vol.269 , pp. 6026-6050
    • Serve, H.1    Hsu, Y.C.2    Besmer, P.3
  • 21
    • 0032543578 scopus 로고    scopus 로고
    • The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Serl36
    • Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Serl36. Curr Biol 1998; 8: 779-82.
    • (1998) Curr Biol , vol.8 , pp. 779-782
    • Blume-Jensen, P.1    Janknecht, R.2    Hunter, T.3
  • 22
    • 0033981729 scopus 로고    scopus 로고
    • Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility
    • Blume-Jensen P, Jiang G, Hyman R, Lee KF, O'Gorman S, Hunter T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility. Nat Genet 2000; 24: 157-62.
    • (2000) Nat Genet , vol.24 , pp. 157-162
    • Blume-Jensen, P.1    Jiang, G.2    Hyman, R.3    Lee, K.F.4    O'Gorman, S.5    Hunter, T.6
  • 23
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615-75.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Timms, J.5    Waterfield, M.D.6
  • 24
    • 0036566548 scopus 로고    scopus 로고
    • Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: Contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration
    • Ueda S, Mizuki M, Ikeda H et al. Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood 2002; 99: 3342-9.
    • (2002) Blood , vol.99 , pp. 3342-3349
    • Ueda, S.1    Mizuki, M.2    Ikeda, H.3
  • 25
    • 0030918253 scopus 로고    scopus 로고
    • c-kit receptor signaling through its phosphatidylinositide-3′- kinase-binding site and protein kinase C: Role in mast cell enhancement of degranulation, adhesion, and membrane ruffling
    • Vosseller K, Stella G, Yee NS, Besmer P. c-kit receptor signaling through its phosphatidylinositide-3′-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling. Mol Biol Cell 1997; 8: 909-22.
    • (1997) Mol Biol Cell , vol.8 , pp. 909-922
    • Vosseller, K.1    Stella, G.2    Yee, N.S.3    Besmer, P.4
  • 26
    • 0034654307 scopus 로고    scopus 로고
    • Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses
    • Kissel H, Timokhina I, Hardy MP et al. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. Embo J 2000; 19: 1312-26.
    • (2000) Embo J , vol.19 , pp. 1312-1326
    • Kissel, H.1    Timokhina, I.2    Hardy, M.P.3
  • 27
    • 0031014530 scopus 로고    scopus 로고
    • Development of c-Kit-positive cells and the onset of electrical rhythmicity in murine small intestine
    • Torihashi S, Ward SM, Sanders KM. Development of c-Kit-positive cells and the onset of electrical rhythmicity in murine small intestine. Gastroenterology 1997; 112: 144-55.
    • (1997) Gastroenterology , vol.112 , pp. 144-155
    • Torihashi, S.1    Ward, S.M.2    Sanders, K.M.3
  • 28
    • 0033039742 scopus 로고    scopus 로고
    • ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle
    • Xue L, Farrugia G, Sarr MG, Szurszewski JH. ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle. Am J Physiol 1999; 276(6 Pt 1): G1373-9.
    • (1999) Am J Physiol , vol.276 , Issue.6 PART 1
    • Xue, L.1    Farrugia, G.2    Sarr, M.G.3    Szurszewski, J.H.4
  • 31
    • 0035044326 scopus 로고    scopus 로고
    • Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase
    • Miller SM, Reed D, Sarr MG, Farrugia G, Szurszewski JH. Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase. Neurogastroenterol Motil 2001; 13: 121-31.
    • (2001) Neurogastroenterol Motil , vol.13 , pp. 121-131
    • Miller, S.M.1    Reed, D.2    Sarr, M.G.3    Farrugia, G.4    Szurszewski, J.H.5
  • 32
    • 0034141598 scopus 로고    scopus 로고
    • Development of the interstitial cell of Cajal: Origin, kit dependence and neuronal and nonneuronal sources of kit ligand
    • Wu JJ, Rothman TP, Gershon MD. Development of the interstitial cell of Cajal: origin, kit dependence and neuronal and nonneuronal sources of kit ligand. J Neurosci Res 2000; 59: 384-401.
    • (2000) J Neurosci Res , vol.59 , pp. 384-401
    • Wu, J.J.1    Rothman, T.P.2    Gershon, M.D.3
  • 33
    • 0030819660 scopus 로고    scopus 로고
    • Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis
    • Ward SM, Harney SC, Bayguinov JR, McLaren GJ, Sanders KM. Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis. J Physiol 1997; 505(Pt 1): 241-58.
    • (1997) J Physiol , vol.505 , Issue.1 PART , pp. 241-258
    • Ward, S.M.1    Harney, S.C.2    Bayguinov, J.R.3    McLaren, G.J.4    Sanders, K.M.5
  • 34
    • 0034720264 scopus 로고    scopus 로고
    • Defects in sensory nerve numbers and growth in mutant Kit and Steel mice
    • Lourenssen S, Motro B, Bernstein A, Diamond J. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 2000; 11: 1159-65.
    • (2000) Neuroreport , vol.11 , pp. 1159-1165
    • Lourenssen, S.1    Motro, B.2    Bernstein, A.3    Diamond, J.4
  • 35
    • 0026454691 scopus 로고
    • c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons
    • Manova K, Bachvarova RF, Huang EJ et al. c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons. J Neurosci 1992; 12: 4663-76.
    • (1992) J Neurosci , vol.12 , pp. 4663-4676
    • Manova, K.1    Bachvarova, R.F.2    Huang, E.J.3
  • 36
    • 0031054245 scopus 로고    scopus 로고
    • Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase
    • Meyers R, Cantley LC. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem 1997; 272: 4384-90.
    • (1997) J Biol Chem , vol.272 , pp. 4384-4390
    • Meyers, R.1    Cantley, L.C.2
  • 37
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • Hartley KO, Cell D, Smith GC et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82: 849-56.
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Cell, D.2    Smith, G.C.3
  • 38
    • 0033574429 scopus 로고    scopus 로고
    • Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
    • Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, Nussbaum RL. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem 1999; 274: 10963-8.
    • (1999) J Biol Chem , vol.274 , pp. 10963-10968
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Wynshaw-Boris, A.4    Nussbaum, R.L.5
  • 39
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993; 92: 1736-44.
    • (1993) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3
  • 40
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H, Worobec AS, Oh CK et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995; 92: 10560-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3
  • 41
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-KTT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
    • Longley BJ, Tyrrell L, Lu SZ et al. Somatic c-KTT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 1996; 12: 312-4.
    • (1996) Nat Genet , vol.12 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3
  • 42
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279: 577-80.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 43
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001; 61: 8118-21.
    • (2001) Cancer Res , vol.61 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3


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