Long-term changes of peripheral blood CD4-positive T cell subsets (Th1, Th2) in chronic hepatitis C patients with a sustained response or no response to IFN

Hepatology Research

Volumn 27, Issue 4, 2003, Pages 260-265

  Shinohara, Mie ^a   Ishii, Koji ^a   Takamura, Naoko ^a  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD4 positive T cell; Chronic hepatitis C; Cytokine; Th1; Th2

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CELL SEPARATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DOSE REGIMEN; DRUG RESPONSE; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

EID: 0346264730     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2003.07.001     Document Type: Article

References (35)

1. Seeff LB. Natural history of viral hepatitis type C. Semin Gastrointest Dis 1995:6:20-7.
2. Sharara AI, Hunt CM, Hamilton JD. Hepatitis C. Ann Int Med 1996;125:658-68.
3. Tarao K, Rino Y, Takemiya S, et al. Close association between high serum ALT and more rapid recurrence of hepatocellular carcinoma in hepatectomized patients with HCV-associated liver cirrhosis and hepatocellular carcinoma. Intervirology 2000;43:20-6.
4. Davis GD, Esteban-Mur P, Rustgi V, et al. Interferon α-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. New Engl J Med 1998;339:1493-9.
5. Missale G, Bertoni R, Lamonaca V, et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of anti-viral cell-mediated immune response. J Clin Invest 1996;98:706-14.
6. Bacosi M, De Angelis A, Ursitti A, et al. Association of circulating CD8+ lymphocytes to a spontaneous and interferon-α induced clearance of HCV. Hepatology Res 2002;23:163-6.
7. Sekiya H, Komatsu T, Isono E, et al. Decrease in the prevalence of IL-4-producing CD4+ T cells in patients with advanced stage of primary biliary cirrhosis. Am J Gastroenterol 1999;94:3589-94.
8. Vergani D, Mieli-Vergani G. Autoimmune hepatitis. Ann Ital Med Int 1996;11:119-24.
9. Penna A, Del Prete G, Cavalli A, et al. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limiting hepatitis B. Hepatology 1997;25:1022-7.
10. Milich DR, Schodel F, Hughes JL, Jones JE, Peterson DL. The hepatitis B virus core and e antigens elicit different Th cell, subsets: Antigen structure can affect Th cell phenotype. J Virol 1997;71:2192-201.
11. Cerny A, Chisari FV. Pathogenesis of chronic hepatitis C. Immunological features of hepatic injury and viral persistence. Hepatology 1999;30:595-601.
12. Simpson KJ, Lukacs NW, Colletti L, Stricter RM, Kunkel SL. Cytokines and the liver. J Hepatol 1997;27:1120-32.
13. Kobayashi K, Ishii M, Igarashi T, et al. Profile of cytokines produced by CD4-positive T lymphocytes stimulated by anti-CD3 antibody in patients with chronic hepatitis C. J Gastroenterol 1998;33:500-7.
14. Napoli J, Bishop GA, McGuinness PH, Painter DM, McCaughan GW. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996;24:759-65.
15. Sarih M, Bouchrit N, Benslimane A. Different cytokines profiles of peripheral blood mononuclear cells from patients with persistent and self-limited hepatitis C virus infection. Immunol Lett 2000;74:117-20.
16. Takamura N, Ishii K, Shinohara M, Matsumaru K, Kawafune T, Sumino Y. Analysis of peripheral blood CD4-positive, cells using intracellular staining method in patients with chronic hepatitis C. J Med Soc Toho Univ 2002;49:45-52.
17. Tanaka T, Tsukiyama K, Yamaguchi K, et al. Significance of specific antibody assay for genotyping of hepatitis C virus. Hepatology 1994;19:1347-53.
18. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic hepatitis. Hepatology 1981;1:431-5.
19. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading, and staging. Hepatology 1994;19:1513-20.
20. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993;159:197-207.
21. Ferrari C, Penna A, Bertoletti A, et al. Antiviral cell-mediated immune responses during hepatitis B and hepatitis C virus infections. Recent Results Cancer Res 1998;154:330-6.
22. Neumann AU, Lam NP, Dahari H, et al. Hepatitis C viral dynamics in vivo and antiviral efficacy of interferon-α therapy. Science 1998;282:103-7.
23. Bekkering FC, Hansen BE, Brouwer JT, Niesters HG, Schalm SW. Viral kinetics in HCV genotype 1: is the second phase of viral decline dose dependent? Hepatology 1999;30:191A.
24. Ishii K, Tamura N, Shinohara M, et al. Intracellular cytokine analysis of CD4-positive T cells predictive of sustained response to interferon therapy for patients with chronic hepatitis C. Dig Dis Sci 2002;47:778-83.
25. Sobue S, Nomura T, Ishikawa T, et al. Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection. J Gastroenterol 2001;36:544-51.
26. Mahmood S, Sho M, Yasuhara Y, et al. Clinical significance of intrahepatic interleukin-8 in chronic hepatitis C patients. Hepatology Res 2002;24:413-9.
27. Orito E, Mizokami M, Suzuki K, et al. Loss of serum HCV RNA at week 4 of interferon-α therapy is associated with more favorable long-term response in patients with chronic hepatitis C. J Med Virol 1995;46:109-15.
28. Kakumu S, Aiyama T, Okumura A, Iwata K, Ishikawa T, Yoshioka K. Earlier loss of hepatitis C virus RNA in interferon therapy can predict a long-term response in chronic hepatitis C. J Gastroenterol Hepatol 1997;12:468-72.
29. Zeuzem S, Lee JH, Frank A, et al. Quantification of the initial decline of serum hepatitis C virus RNA and response to interferon α. Hepatology 1998;27:1149-56.
30. Fan XG, Liu WE, Li CZ, et al. Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection. Mediators Inflamm 1998;7:295-7.
31. Nagler A, Lanier LL, Phillips JH. The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation. J Immunol 1988;141:2349-51.
32. Martinez OM, Gibbons RS, Garovoy MR, Aronson FR. IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells. J Immunol 1990;144:2211-5.
33. Fiorentino DF, Zlotnik A, Vieira P, et al. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991;146:3444-51.
34. He XS, Rehermann B, Lopez-Labrador FX, et al. Quantitative analysis of hepatitis C virus-specific CD8 (+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci USA 1999;96:5692-7.
35. Bertoletti A, D'Elios MM, Boni C, et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infection. Gastroenterology 1997;112:193-9.