메뉴 건너뛰기




Volumn 18, Issue 12, 2003, Pages 2683-2688

Proinsulin serum concentrations in women with polycystic ovary syndrome: A marker of β-cell dysfunction?

Author keywords

Polycystic ovary syndrome; Proinsulin; cell function

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; C PEPTIDE; GLUCOSE; INSULIN; PROINSULIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

EID: 0346147068     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg482     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 0022519137 scopus 로고
    • Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism
    • Adams, J., Polson, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355-359.
    • (1986) Br. Med. J. , vol.293 , pp. 355-359
    • Adams, J.1    Polson, D.W.2    Franks, S.3
  • 2
    • 0027449919 scopus 로고
    • Hyperinsulinaemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin
    • Conway, G.S., Clark, P.M. and Wong, D. (1993) Hyperinsulinaemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin. Clin. Endocrinol. (Oxf.), 38, 219-222.
    • (1993) Clin. Endocrinol. (Oxf.) , vol.38 , pp. 219-222
    • Conway, G.S.1    Clark, P.M.2    Wong, D.3
  • 3
    • 0030783746 scopus 로고    scopus 로고
    • Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome
    • Ciampelli, M., Fulghesu, A.M., Cucinelli, F., Pavone, V., Caruso, A., Mancuso, S. and Lanzone, A. (1997) Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod., 12, 1897-1901.
    • (1997) Hum. Reprod. , vol.12 , pp. 1897-1901
    • Ciampelli, M.1    Fulghesu, A.M.2    Cucinelli, F.3    Pavone, V.4    Caruso, A.5    Mancuso, S.6    Lanzone, A.7
  • 5
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif, A., Segal, K.R., Futterweit, W. and Dobrjansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 6
    • 0029880488 scopus 로고    scopus 로고
    • Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
    • Dunaif, A. and Fingood, D. (1996) Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 81, 942-947.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 942-947
    • Dunaif, A.1    Fingood, D.2
  • 7
    • 85047696604 scopus 로고
    • Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
    • Ehrmann, D.A., Barnes, R.B. and Rosenfield, R.L. (1995) Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr. Rev., 16, 322-353.
    • (1995) Endocr. Rev. , vol.16 , pp. 322-353
    • Ehrmann, D.A.1    Barnes, R.B.2    Rosenfield, R.L.3
  • 8
    • 0344286476 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome
    • Ehrmann, D.A., Barnes, R.B., Rosenfield, R.L., Cavaghan, M.K. and Imperial, J. (1999) Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care, 22, 141-146.
    • (1999) Diabetes Care , vol.22 , pp. 141-146
    • Ehrmann, D.A.1    Barnes, R.B.2    Rosenfield, R.L.3    Cavaghan, M.K.4    Imperial, J.5
  • 9
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini, E. (1998) Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects. Endocr. Rev., 19, 477-490.
    • (1998) Endocr. Rev. , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 10
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 853-861
    • Franks, S.1
  • 12
    • 0025125772 scopus 로고
    • Incidence of Type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution
    • Haffner, S.M., Stern, M.P., Mitchell, B.D., Hazuda, H.P. and Patterson, J.K. (1990) Incidence of Type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes, 39, 283-288.
    • (1990) Diabetes , vol.39 , pp. 283-288
    • Haffner, S.M.1    Stern, M.P.2    Mitchell, B.D.3    Hazuda, H.P.4    Patterson, J.K.5
  • 14
    • 0028848244 scopus 로고
    • Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans
    • Haffner, S.M., Miettinen, H., Gaskill, S.P. and Stern, M.P. (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes, 44, 1386-1391.
    • (1995) Diabetes , vol.44 , pp. 1386-1391
    • Haffner, S.M.1    Miettinen, H.2    Gaskill, S.P.3    Stern, M.P.4
  • 15
    • 0030849251 scopus 로고    scopus 로고
    • Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: The Mexico City Diabetes Study
    • Haffner, S.M., Gonzalez, C., Mykkänen, L. and Stern, M. (1997) Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: The Mexico City Diabetes Study. Diabetologia, 40, 830-837.
    • (1997) Diabetologia , vol.40 , pp. 830-837
    • Haffner, S.M.1    Gonzalez, C.2    Mykkänen, L.3    Stern, M.4
  • 17
    • 0023412220 scopus 로고
    • Epidemiology of infertility and polycystic ovarian disease: Endocrinological and demographic studies
    • Hull, M.G. (1987) Epidemiology of infertility and polycystic ovarian disease: Endocrinological and demographic studies. Gynecol. Endocrinol., 1, 235-245.
    • (1987) Gynecol. Endocrinol. , vol.1 , pp. 235-245
    • Hull, M.G.1
  • 18
    • 0036306096 scopus 로고    scopus 로고
    • Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S
    • Jensen, C.C., Cnop, M., Hull, R.L., Fujimoto, W.Y., Kahn, S.E., American Diabetes Association GENNID Study Group (2002) Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes, 51, 2170-2178.
    • (2002) Diabetes , vol.51 , pp. 2170-2178
    • Jensen, C.C.1    Cnop, M.2    Hull, R.L.3    Fujimoto, W.Y.4    Kahn, S.E.5
  • 19
    • 0028967995 scopus 로고
    • Relationship of proinsulin and insulin with non-insulin-dependent diabetes and coronary heart disease in Japanese American men: Impact of obesity - Clinical research Center study
    • Kahn, S.E., Leonetti, D.L., Prigeon, R.L., Boyko, E.J., Bergstrom, R.W. and Fujimoto, W.Y. (1995) Relationship of proinsulin and insulin with non-insulin-dependent diabetes and coronary heart disease in Japanese American men: Impact of obesity - Clinical research Center study. J. Clin. Endocrinol. Metab., 80, 1399-1406.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 1399-1406
    • Kahn, S.E.1    Leonetti, D.L.2    Prigeon, R.L.3    Boyko, E.J.4    Bergstrom, R.W.5    Fujimoto, W.Y.6
  • 20
    • 0031773509 scopus 로고    scopus 로고
    • Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study
    • Knochenhauer, E.S., Key, T.J., Kahsar-Miller, M., Waggoner, W., Boots, L.R. and Azziz, R. (1998) Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. J. Clin. Endocrinol. Metab., 83, 3078-3082.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 3078-3082
    • Knochenhauer, E.S.1    Key, T.J.2    Kahsar-Miller, M.3    Waggoner, W.4    Boots, L.R.5    Azziz, R.6
  • 21
    • 0032948363 scopus 로고    scopus 로고
    • Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
    • Legro, R.S., Kunselman, A.R., Dodson, W.C. and Dunaif, A. (1999) Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women. J. Clin. Endocrinol. Metab., 84, 165-169.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 165-169
    • Legro, R.S.1    Kunselman, A.R.2    Dodson, W.C.3    Dunaif, A.4
  • 22
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda, M. and DeFronzo, R.A. (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp. Diabetes Care, 22, 1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 23
    • 0030843939 scopus 로고    scopus 로고
    • Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects
    • Matsumoto, K., Miyake, S., Yano, M., Ueki, Y., Yamaguchi, Y., Akazawa, S. and Tominaga, Y. (1997) Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care, 20, 1562-1568.
    • (1997) Diabetes Care , vol.20 , pp. 1562-1568
    • Matsumoto, K.1    Miyake, S.2    Yano, M.3    Ueki, Y.4    Yamaguchi, Y.5    Akazawa, S.6    Tominaga, Y.7
  • 24
    • 0029050206 scopus 로고
    • Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
    • Mykkänen, L., Haffner, S.M., Kuusisto, J., Pyorala, K., Hales, C.N. and Laakso, M. (1995). Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia, 38, 1176-1182.
    • (1995) Diabetologia , vol.38 , pp. 1176-1182
    • Mykkänen, L.1    Haffner, S.M.2    Kuusisto, J.3    Pyorala, K.4    Hales, C.N.5    Laakso, M.6
  • 25
    • 0030781055 scopus 로고    scopus 로고
    • The relation to proinsulin, insulin and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycaemic subjects
    • Mykkänen, L., Haffner, S.M., Hales, C.N., Ronnemaa, T. and Laakso, M. (1997) The relation to proinsulin, insulin and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycaemic subjects. Diabetes, 46, 1990-1995.
    • (1997) Diabetes , vol.46 , pp. 1990-1995
    • Mykkänen, L.1    Haffner, S.M.2    Hales, C.N.3    Ronnemaa, T.4    Laakso, M.5
  • 27
    • 0027434701 scopus 로고
    • Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance
    • Reaven, G.M., Chen, Y.D., Hollenbeck, C.B., Sheu, W.H., Ostrega, D. and Polonsky, K.S. (1993) Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J. Clin. Endocrinol. Metab., 76, 44-48.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 44-48
    • Reaven, G.M.1    Chen, Y.D.2    Hollenbeck, C.B.3    Sheu, W.H.4    Ostrega, D.5    Polonsky, K.S.6
  • 28
    • 0031791047 scopus 로고    scopus 로고
    • Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
    • Roder, M.E., Porte, D. Jr, Schwartz, R.S. and Kahn, S.E. (1998) Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab., 83, 604-608.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 604-608
    • Roder, M.E.1    Porte Jr., D.2    Schwartz, R.S.3    Kahn, S.E.4
  • 33
    • 0032949675 scopus 로고    scopus 로고
    • Fasting proinsulin concentrations predict the development of Type 2 diabetes
    • Wareham, N.J., Byrne, C.D., Williams, R., Day, N.E. and Hales, C.N. (1999) Fasting proinsulin concentrations predict the development of Type 2 diabetes. Diabetes Care, 22, 262-270.
    • (1999) Diabetes Care , vol.22 , pp. 262-270
    • Wareham, N.J.1    Byrne, C.D.2    Williams, R.3    Day, N.E.4    Hales, C.N.5
  • 35
    • 0003725206 scopus 로고    scopus 로고
    • Report of a WHO Consultation, Part I: Diagnosis and Classification of Diabetes Mellitus. World Health Organization, Geneva
    • World Health Organization (1999) Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Report of a WHO Consultation, Part I: Diagnosis and Classification of Diabetes Mellitus. World Health Organization, Geneva.
    • (1999) Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications
  • 36
    • 0001217801 scopus 로고
    • Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach
    • In Hershmann, J.M. (ed.); Blackwell, Boston
    • Zawadzki, J.K. and Dunaif, A. (1992) Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. In Hershmann, J.M. (ed.), Current Issues in Endocrinology and Metabolism. Blackwell, Boston, pp. 377-384.
    • (1992) Current Issues in Endocrinology and Metabolism , pp. 377-384
    • Zawadzki, J.K.1    Dunaif, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.