The mGlu2/3 receptor agonist, LY354740, blocks immobilization-induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex

Journal of Neurochemistry

Volumn 88, Issue 1, 2004, Pages 194-202

  Swanson, Chad J ^a   Perry, Kenneth W ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Metabotropic glutamate receptors; Microdialysis; Monoamines; Norepinepherine; Stress

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; CITALOPRAM; DOPAMINE; EGLUMETAD; METABOTROPIC RECEPTOR; NORADRENALIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE RELEASE; DOPAMINE RELEASE; DOSE RESPONSE; EVALUATION; IMMOBILIZATION STRESS; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ANIMALIA; RODENTIA;

EID: 0346102597     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02125.x     Document Type: Article

References (40)

1. Abercrombie E. D. and Jacobs B. L. (1987) Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. 1. Acutely presented stressful and nonstressful stimuli. J. Neurosci. 7, 2837-2843.
2. Cartmell J. and Schoepp D. D. (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J. Neurochem. 75, 889-907.
3. Cartmell J., Perry K. W., Salhoff C. R., Monn J. A. and Schoepp D. D. (2001) Acute increases in monoamine release in the rat prefontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. Neuropharmacology 40, 847-855.
4. Charney D. S., Heninger G. R. and Breier A. (1984) Noradrenergic function in panic anxiety. Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Arch. Gen. Psychiatry 41, 751-763.
5. Claustre Y., Rivy J. P., Dennis T. and Scatton B. (1986) Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat. J. Pharmacol. Exp. Ther. 238, 693-700.
6. Clement H. W., Schafer F., Ruwe C., Gemsa D. and Wesemann W. (1993) Stress-induced changes of extracellular 5-hydroxyindoleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat. Brain Res. 614, 117-124.
7. Cole B. J. and Robbins T W. (1992) Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacology. 7, 129-142.
8. D'Angio M., Serrano A., Rivy J. P. and Scatton B. (1990) Tail-pinch stress increases extracellular DOPAC levels (as measured by in vivo voltammetry) in the rat nucleus accumbens but not frontal cortex: antagonism by diazepam and zolpidem. Brain Res. 409, 169-174.
9. De Souza E. B. and Van Loon G. R. (1986) Brain serotonin and catecholamine responses to repeated stress in rats. Brain Res. 367, 77-86.
10. Dube G. R. and Marshall K. C. (1997) Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors. Neurosci. 80, 511-521.
11. Feenstra M. G., Botterblom M. H. and van Uum J. F. (1998) Local activation of metabotropic glutamate receptors inhibits the handling-induced increased release of dopamine in the nucleus accumbens but not that of dopamine or noradrenaline in the prefrontal cortex: comparison with inhibition of ionotropic receptors. J. Neurochem. 70, 1104-1113.
12. Foote S. L., Bloom F. E. and Aston-Jones G. (1983) Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol. Rev. 63, 844-914.
13. Glavin G. B. (1985) Stress and brain noradrenaline: a review. Neurosci. Biobehav. Rev. 9, 233-243.
14. Helton D. R., Tizzano J. P., Monn J. A., Schoepp D. D. and Kallman M. J. (1998) Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J. Pharmacol. Exp. Ther. 284, 651-660.
15. Ida Y., Tanaka M., Tsuda A., Tsujimaru S. and Nagasaki N. (1985) Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats: antagonism by Ro 15-1788. Life Sci. 37, 2491-2498.
16. Ida Y., Tsuda A., Sueyoshi K., Shirao I. and Tanaka M. (1989) Blockade by diazepam of conditioned fear-induced activation of rat mesoprefrontal dopamine neurons. Pharmacol. Biochem. Behav. 33, 477-479.
17. Kingston A. E., Ornstein P. L., Wright R. A., Johnson B. G., Mayne N. G., Burnett J. P., Belagaje R., Wu S. and Schoepp D. D. (1998) LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37, 1-12.
18. Knorr A. M., Deutch A. Y. and Roth R. H. (1989) The anxiogenic beta-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495, 355-361.
19. Matuszewich L., Filon M. E., Finn D. A. and Yamamoto B. K. (2002) Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine. Neuroscience 110, 41-48.
20. Moghaddam B. (2002) Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders. Biol. Psychiatry 51, 775-787.
21. Moghaddam B. and Adams B. W. (1998) Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281, 1349-1352.
22. Monn J. A., Valli M. J., Massey S. M. et al. (1997) Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J. Med. Chem. 40, 528-537.
23. Morrow B. A. and Roth R. H. (1996) Serotonergic lesions alter cocaine-induced locomotor behavior and stress-activation of the mesocorticolimbic dopamine system. Synapse 23, 174-181.
24. Nakahara D. and Nakamura M. (1999) Differential effect of immobilization stress on in vivo synthesis rate of monoamines in medial prefrontal cortex and nucleus accumbens of conscious rats. Syn Sjilapse 32, 238-242.
25. Nakane H., Shimizu N. and Hori T. (1994) Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. Am. J. Physiol. 267, R1559-R1566.
26. Omstein P. L., Bleisch T. J., Arnold M. B. et al. (1998) 2-Substituted (2SR)-2-amino-2-(1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. J. Med. Chem. 41, 358-378.
27. Paxinos G. and Watson C. (1986) A Stereotaxic Atlas of the Rat Brain. New York: Academic.
28. Redmond D. E. Jr and Huang Y. H. (1979) Current concepts. II. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sci. 25, 2149-2162.
29. Roth R. H., Tam S. Y., Ida Y., Yang J. X. and Deutch A. Y. (1988) Stress and the mesocorticolimbic dopamine systems. Ann. N Y Acad. Sci. 537, 138-147.
30. Schoepp D. D. (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J. Pharmacol. Exp. Ther 299, 12-20.
31. Schoepp D. D., Carmell J., Johnson B. G., Salhoff C. R., Wright R. A., Tizzano J. P. and Monn J. A. (2001) Metabotropic glutamate receptors: A novel approach to treat psychiatric disorders, in Excitatory Amino Acids: Ten Years Later (Turski, L., Schoepp, D. D. and Cavalheiro, E. A., eds), pp. 207-216. IOS Press, Washington.
32. Shekhar A. and Keim S. R. (2000) LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats. Neuropharmacology. 39, 1139-1146.
33. Singewald N., Zhou G. Y. and Schneider C. (1995) Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress. Brain Res. 704, 42-50.
34. Thiebot M. H., Jobert A. and Soubrie P. (1980a) Chlordiazepoxide and GABA injected into raphe dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component. Neuropharmacology 19, 633-641.
35. Thiebot M. H., Jobert A. and Soubrie P. (1980b) Conditioned suppression of behavior: its reversal by intra raphe microinjection of chlordiazepoxide and GABA. Neurosci. Lett. 16, 213-217.
36. Thierry A. M., Tassin J. P., Blanc G. and Glowinski J. (1976) Selective activation of mesocortical DA system by stress. Nature 263, 242-244.
37. U'Prichard D. C., Reisine T. D., Mason S. T., Fibiger H. C. and Yamamura H. I. (1980) Modulation of rat brain alpha- and beta-adrenergic receptor populations by lesion of the dorsal noradrenergic bundle. Brain Res. 187, 143-154.
38. Ungerstedt U. (1971) Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand. Suppl. 367, 1-48.
39. Vandergriff J. and Rasmussen K. (1999) The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropharmacology 38, 217-222.
40. Woods J. H., Katz J. L. and Winger G. (1992) Benzodiazepines: use, abuse, and consequences. Pharmacol. Rev. 44, 151-347.