Signaling advances from immunogenetics to immunogenomics

Genome Biology

Volumn 4, Issue 12, 2003, Pages

  Boothby, Mark ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ETHYLNITROSOUREA; RETROVIRUS VECTOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR;

CHEMICAL MUTAGENESIS; DNA LIBRARY; EXPERIMENTAL MODEL; GENE FUNCTION; GENE MUTATION; GENETIC SCREENING; GENOMICS; IMMUNE RESPONSE; IMMUNOGENETICS; IMMUNOREGULATION; MOUSE; NONHUMAN; PHENOTYPE; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; GENOMICS; IMMUNOGENETICS; MICE; SIGNAL TRANSDUCTION;

UNIDENTIFIED RETROVIRUS;

EID: 0345865038     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: 10.1186/gb-2003-4-12-239     Document Type: Short Survey

References (28)

1. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, et al.: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003, 424:743-748.
2. Chu P, Pardo J, Zhao H, Li CC, Pali E, Shen MM, Qu K, Yu SX, Huang BCB, Yu P, et al.: Systematic identification of regulatory proteins critical for T-cell activation. J Biol 2003, 2:21.
3. Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC: Widespread failure of hematolymphoid differentiation caused by a recessive nichefilling allele of the Ikaros transcription factor. Immunity 2003, 19:131-144.
4. Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, et al.: Identifying the MAGUK protein Carma-I as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 2003, 18:751-762.
5. Todd JA, Wicker LS: Genetic protection from the inflammatory disease type I diabetes in humans and animal models. Immunity 2001, 15:387-395.
6. McKendry R, John J, Flavell D, Muller M, Kerr IM, Stark GR: High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc Natl Acad Sci USA 1991, 88:11455-11459.
7. Velazquez L, Fellous M, Stark GR, Pellegrini S: A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992, 70:313-22.
8. Darnell JE Jr, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1421.
9. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al.: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998, 282:2085-2088.
10. Shinkura R, Kitada K, Matsuda F, Tashiro K, Ikuta K, Suzuki M, Kogishi K, Serikawa T, Honjo T: Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-kappa B-inducing kinase. Nat Genet 1999, 22:74-77.
11. Goldsmith MA, Weiss A: Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. Proc Natl Acad Sci USA 1987, 84:6879-6883.
12. Straus DB, Weiss A: Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 1992, 70:585-593.
13. Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nunez G, Bertin J, Lin X: A requirement for CARMAI in TCR-induced NF-kappa B activation. Nat Immunol 2002, 3:830-835.
14. Chen Z, Friedrich GA, Soriano P: Transcriptional enhancer factor I disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Devel 1994, 8:2293-2301.
15. Ruley HE: Functional genomics of the murine immune system. Immunol Res 2001, 23:289-299.
16. Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, et al.: Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet 2000, 24:175-179.
17. Lexicon Genetics [http://www.lexgen.com/]
18. BayGenomics [http://baygenomics.ucsf.edu/]
19. Hitotsumachi S, Carpenter DA, Russell WL: Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc Natl Acad Sci USA 1985, 82:6619-6621.
20. Hrabe de Angelis M, Balling R: Large scale ENU screens in the mouse: genetics meets genomics. Mutat Res 1998, 400:25-32.
21. Rathkolb B, Fuchs E, Kolb HJ, Renner-Muller I, Krebs O, Balling R, Hrabe de Angelis M, Wolf E: Large-scale N-ethyl-N-nitrosourea mutagenesis of mice - from phenotypes to genes. Exp Physiol 2000, 85:635-644.
22. Nelms KA, Goodnow CC: Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 2001, 15:409-418.
23. Takeda K, Kaisho T, Akira S: Toll-like receptors. Annu Rev Immunol 2003, 21:335-376.
24. Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, et al.: The MAGUK family protein CARD II is essential for lymphocyte activation. Immunity 2003, 18:763-775.
25. Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O'Brien W, Thome M, Littman DR: Requirement for CARMAI in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 2003, 13:1252-1258.
26. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, et al.: Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003, 111:1863-1874.
27. Chen Z, Lund R, Aittokallio T, Kosonen M, Nevalainen O, Lahesmaa R: Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol 2003, 171:3627-3635.
28. Macian F, Garcia-Cozar F, Im SH, Horton HF, Byrne MC, Rao A: Transcriptional mechanisms underlying lymphocyte tolerance. Cell 2002, 109:719-731.