A balanced expression of two chains of heterodimer protein, the human interleukin-12, improves high-level expression of the protein in CHO cells

Biochemical and Biophysical Research Communications

Volumn 313, Issue 2, 2004, Pages 287-293

  Liu, Wentao ^a   Wei, Haiming ^a   Liang, Shujuan ^b   Zhang, Jian ^b   Sun, Rui ^a,b   Tian, Zhigang ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Chinese hamster ovary; Expression efficiency; Gene transfection; Heterodimer protein; Interleukin 12

Indexed keywords

COMPLEMENTARY DNA; DIMER; INTERLEUKIN 12; PROTEIN P35; PROTEIN P40; PROTEIN P70;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DIMERIZATION; DNA TRANSFECTION; EXPRESSION VECTOR; GENE AMPLIFICATION; GENE INSERTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CRICETINAE; CRICETULUS GRISEUS; VECTORS;

EID: 0345735304     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.11.125     Document Type: Article

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