Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

Nature Biotechnology

Volumn 15, Issue 1, 1997, Pages 35-40

  Lieschke, Graham J ^a,c   Rao, Prakash K ^a,d   Gately, Maurice K ^b   Mulligan, Richard C ^a,d  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Cytokine; Fusion protein; Interleukin; Retrovirus; Tumor immunotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; HYBRID PROTEIN; INTERLEUKIN 12;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER IMMUNOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR REGRESSION;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSARCOMA; GENETIC VECTORS; HUMANS; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0031012127     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0197-35     Document Type: Article

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