Functional Analysis of the Mycobacterium tuberculosis MprAB Two-Component Signal Transduction System

Infection and Immunity

Volumn 71, Issue 12, 2003, Pages 6962-6970

  Zahrt, Thomas C ^a   Wozniak, Christopher ^a,c   Jones, Denise ^a,b   Trevett, Andrea ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ASPARTIC ACID DERIVATIVE; BACTERIAL PROTEIN; BCG VACCINE; HISTIDINE DERIVATIVE; PHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN MPRA; PROTEIN MPRB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE FUNCTION; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOUSE; MUTAGENESIS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATOR GENE; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; CATTLE; CELL LINE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0345714738     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.12.6962-6970.2003     Document Type: Article

References (44)

1. Arthur, M., F. Depardieu, and P. Courvalin. 1999. Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci. Microbiology 145:1849-1858.
2. Boon, C., and T. Dick. 2002. Mycobacterium bovis BCG response regulator essential for hypoxic dormancy. J. Bacteriol. 184:6760-6767.
3. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry III, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M.-A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, and B. G. Barrell. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
4. Delgado, J., S. Forst, S. Harlocker, and M. Inouye. 1993. Identification of a phosphorylation site and functional analysis of conserved aspartic acid residues of OmpR, a transcriptional activator for ompF and ompC in Escherichia coli. Mol. Microbiol. 10:1037-1047.
5. Ewann, F., M. Jackson, K. Pethe, A. Cooper, N. Mielcarek, D. Ensergueix, B. Gicquel, C. Locht, and P. Supply. 2002. Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis. Infect. Immun. 70:2256-2263.
6. Flynn, J. L., and J. Chan. 2001. Tuberculosis: latency and reactivation. Infect. Immun. 69:4195-4201.
7. Gilles-Gonzalez, M. A., and G. Gonzalez. 1993. Regulation of the kinase activity of heme protein FixL from the two-component system FixL/FiJ of Rhizobium meliloti. J. Biol. Chem. 268:16293-16297.
8. Glickman, M. S., and W. R. Jacobs, Jr. 2001. Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 104:477-485.
9. Graham, J. E., and J. E. Clark-Curtiss. 1999. Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc. Natl. Acad. Sci. USA 96:11554-11559.
10. Graham, M. R., L. M. Smoot, C. A. Migilaccio, K. Virtaneva, D. E. Sturdevant, S. F. Porcella, M. J. Federle, G. J. Adams, J. R. Scott, and J. M. Musser. 2002. Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc. Natl. Acad. Sci. USA 99:13855-13860.
11. Haydel, S. E., N. E. Dunlap, and W. H. Benjamin, Jr. 1999. In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins. Microb. Pathog. 26:195-206.
12. Himpens, S., C. Locht, and P. Supply. 2000. Molecular characterization of the mycobacterial SenX3-RegX3 two-component system: evidence for autoregulation. Microbiology 146:3091-3098.
13. Honer zu Bentrup, K., and D. G. Russell. 2001. Mycobacterial persistence: adaptation to a changing environment. Trends Microbiol. 9:597-605.
14. Hsing, W., and T. J. Silhavy. 1997. Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli. J. Bacteriol. 179:3729-3735.
15. Jacobs, W. R., Jr., G. V. Kalpana, J. D. Cirillo, L. Pascopella, S. B. Snapper, R. A. Udani, W. Jones, R. G. Barletta, and B. R. Bloom. 1991. Genetic systems for mycobacteria. Methods Enzymol. 204:537-555.
16. Jeon, Y., Y. S. Lee, J. S. Han, J. B. Kim, and D. S. Hwang. 2001. Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system. J. Biol. Chem. 276:40873-40879.
17. Li, Y., and L. Plamann. 1996. Purification and in vitro phosphorylation of Myxococcus xanthus AsgA protein. J. Bacteriol. 178:289-292.
18. Lutter, P., H. E. Meyer, M. Langer, K. Witthohn, W. Dormeyer, A. Sickmann, and M. Bluggel. 2001. Investigation of charge variants of rViscumin by two-dimensional gel electrophoresis and mass spectrometry. Electrophoresis 22:2888-2897.
19. Martinez-Hackert, E., and A. M. Stock. 1997. Structural relationships in the OmpR family of winged-helix transcription factors. J. Mol. Biol. 269:301-312.
20. Matsubara, M., S. I. Kitaoka, S. I. Takeda, and T. Mizuno. 2000. Tuning of the porin expression under anaerobic growth conditions by His-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli. Genes Cells 5:555-569.
21. Mattison, K., and L. J. Kenney. 2002. Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ. J. Biol. Chem. 277:11143-11148.
22. McCleary, W. R., and J. B. Stock. 1994. Acetyl phosphate and the activation of two-component response regulators. J. Biol. Chem. 269:31567-31572.
23. McCleary, W. R., and D. R. Zusman. 1990. Purification and characterization of the Myxococcus xanthus FrzE protein shows that it has autophosphorylation activity. J. Bacteriol. 172:6661-6668.
24. Murray, C. J., and J. A. Salomon. 1998. Modeling the impact of global tuberculosis control strategies. Proc. Natl. Acad. Sci. USA 95:13881-13886.
25. Nakano, M. M., and Y. Zhu. 2001. Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth. J. Bacteriol. 183:1938-1944.
26. Oshima, T., H. Aiba, Y. Masuda, S. Kanaya, M. Sugiura, B. L. Wanner, H. Mori, and T. Mizuno. 2002. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Mol. Microbiol. 46:281-291.
27. O'Toole, R., M. J. Smeulders, M. C. Blokpoel, E. J. Kay, K. Lougheed, and H. D. Williams. 2003. A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis. J. Bacteriol. 185:1543-1554.
28. Parish, T., D. A. Smith, S. Kendall, N. Casali, G. J. Bancroft, and N. G. Stoker. 2003. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect. Immun. 71:1134-1140.
29. Park, H. D., K. M. Guinn, M. I. Harrell, R. Liao, M. I. Voskuil, M. Tompa, G. K. Schoolnik, and D. R. Sherman. 2003. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 48:833-843.
30. Parkinson, J. S., and E. C. Kofoid. 1992. Communication modules in bacterial signaling proteins. Annu. Rev. Genet. 26:71-112.
31. Parrish, N. M., J. D. Dick, and W. R. Bishai. 1998. Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol. 6:107-112.
32. Perez, E., S. Samper, Y. Bordas, C. Guilhot, B. Gicquel, and C. Martin. 2001. An essential role for phoP in Mycobacterium tuberculosis virulence. Mol. Microbiol. 41:179-187.
33. Porter, S. L., and J. P. Armitage. 2002. Phosphotransfer in Rhodobacter sphaeroides chemotaxis. J. Mol. Biol. 324:35-45.
34. Rook, G. A., and R. Hernandez-Pando. 1996. The pathogenesis of tuberculosis. Annu. Rev. Microbiol. 50:259-284.
35. Schluger, N. W. 2000. The impact of drug resistance on the global tuberculosis epidemic. Int. J. Tuberc. Lung Dis. 4:S71-S75.
36. Stock, A. M., V. L. Robinson, and P. N. Goudreau. 2000. Two-component signal transduction. Annu. Rev. Biochem. 69:183-215.
37. Stock, J. B., M. G. Surette, M. Levit, and P. Park. 1995. Two-component signal transduction systems: structure-function relationships and mechanisms of catalysis, p. 25-51. In J. A. Hoch and T. J. Silhavy (ed.), Two-component signal transduction. American Society for Microbiology, Washington, D.C.
38. Tran, V. K., R. Oropeza, and L. J. Kenney. 2000. A single amino acid substitution in the C terminus of OmpR alters DNA recognition and phosphorylation. J. Mol. Biol. 299:1257-1270.
39. Via, L. E., R. Curcic, M. H. Mudd, S. Dhandayuthapani, R. J. Ulmer, and V. Deretic. 1996. Elements of signal transduction in Mycobacterium tuberculosis: in vitro phosphorylation and in vivo expression of the response regulator MtrA. J. Bacteriol. 178:3314-3321.
40. Wayne, L. G., and L. G. Hayes. 1996. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64:2062-2069.
41. Zahrt, T. C. 2003. Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection. Microbes Infect. 5:159-167.
42. Zahrt, T. C., and V. Deretic. 2000. An essential two-component signal transduction system in Mycobacterium tuberculosis. J. Bacteriol. 182:3832-3838.
43. Zahrt, T. C., and V. Deretic. 2001. Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc. Natl. Acad. Sci. USA 98:12706-11711.
44. Zumla, A., P. Mwaba, S. B. Squire, and J. M. Grange. 1999. The tuberculosis pandemic-which way now? J. Infect. 38:74-79.