Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding

NeuroToxicology

Volumn 22, Issue 1, 2001, Pages 49-62

  Crumpton, T ^a   Atkins, D S ^a   Zawia, N H ^b   Barone Jr , S ^c  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Lead neurotoxicity; Nerve growth factor; Neurite outgrowth; NGF; Sp1

Indexed keywords

LEAD; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL SIZE; DENSITOMETRY; DNA; LEAD; NERVE GROWTH FACTOR; NEURITES; NEURONS; PC12 CELLS; RATS; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR;

EID: 0035109194     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(00)00008-5     Document Type: Article

References (70)

1. Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells
2. Neonatal lead exposure retards cortical synaptogenesis in the rat
3. Functional analysis of the proximal 5′-flanking region of the N-methyl-D-aspartate receptor subunit gene NMDAR1
4. Vulnerable processes of nervous system development: A review of markers and methods
5. Growth factors and membrane depolarization activate distinct programs of early response gene expression: Dissociation of fos and jun induction
6. Differential vulnerability of mixed and cutaneous nerves in lead neuropathy
7. Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1
8. Purification and biochemical characterization of the promoter-specific transcription factor Sp1
9. Neonatal lead exposure in the rat: Decreased learning as a function of age and blood lead concentrations
10. The effects of lead on the developing central nervous system of the rat
11. Morphometric effects of postnatal lead exposure on hippocampal development of the 15-day-old rat
12. Increased AP1 DNA binding activity in PC12 cells treated with lead
13. Low lead levels stunt neuronal growth in a reversible manner
14. Delayed behavioral toxicity of lead with increasing exposure concentration
15. Performance and exposure indices of rats exposed to low concentrations of lead
16. Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms
17. Examination of neuronal differentiation and AChE activity in PC12 cells following exposure to chlorpyrifos or its metabolites: Is cholinesterase activity the target site of action?
18. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
19. Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II
20. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
21. Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice
22. Multiple specific contacts between a mammalian transcription factor and its cognate promoters
23. Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions
24. The nerve growth factor: Biochemistry synthesis and mechanism of action
25. PC12 cells as a model of neuronal differentiation
26. Xenopus transcription factor A requires zinc for binding to the 5S RNA gene
27. Lead inhibition of DNA-binding mechanism of CYS2-HIS2 zinc finger proteins
28. The effect of lead toxicity and milk deprivation of myelination in the rat
29. Lead-induced alterations of glial fibrillary acidic protein (GFAP) in the developing rat brain
30. The transcription factor SP1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain
31. Inorganic lead may inhibit neurite development in cultured rat hippocampal neurons through hyperphosphorylation
32. Dendritic spine changes in rat hippocampal pyramidal cells after postnatal lead treatment: A Golgi study
33. Nuclear proteins binding to the human metallothionein-IIA gene upstream sequences
34. Lead
35. Effect of lead intoxication on the postnatal growth of the rat nervous system
36. Inhibition of astroglia-induced endothelial differentiation by inorganic lead: A role for protein kinase C
37. A cobalt complex that selectively disrupts the structure and function of zinc fingers
38. The effect of lead on mouse brain development
39. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
40. Lead activates protein kinase C in immature rat brain microvessels
41. The effect of prenatal and postnatal lead exposure on neonatal synaptogenesis in rat cerebral cortex
42. The effects of postnatal lead exposure on Purkinje cell dendritic development in the rat
43. Effects of inorganic lead on RNA, DNA and protein content in the developing neonatal rat brain
44. 2+ both activates and inhibits protein kinase C purified from rat brain and neuronal cell cultures
45. Alteration of DNA binding specificity by nickel(II) substitution in three zinc(II) fingers of transcription factor Sp1
46. Issues of lead toxicity
47. Transcription factor Sp1 expressed three different developmentally regulated mRNAs in mouse spermatogenic cells
48. Effects of lead exposure during development on neocortical dendritic and synaptic structure
49. Early lead exposure and the hippocampus: A review and recent advances
50. Time of exposure and time of testing in developmental neurotoxicology
51. Critical periods for morphologic assessment
52. Prenatal and perinatal low level lead exposure alters brainstem auditory evoked responses in infants
53. Developmental expression of Sp1 in the mouse
54. GAP-43 mRNA expression in the developing rat brain: Alterations following lead-acetate exposure
55. Differential regulation of E2F and Sp1-mediated transcription by Gl cyclins
56. Damage to the NBM leads to a sustained lesion-induced increase in functional NGF in the cortex
57. Mechanisms of lead neurotoxicity, or looking beyond the lamppost
58. Finger-loops, oncogenes
59. Transition metals modulate DNA-protein interactions of SP1 zinc finger domains with its cognate target site
60. Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells
61. 2+ and protein kinase C and its role in norepinephrine release from bovine adrenal chromaffin cells
62. Effect of nerve growth factor on AP-1 NF-kappa B, and Oct DNA binding activity in apoptotic PC12 cells: Extrinsic and intrinsic elements
63. Lithium attenuates nerve growth factor-induced activation of AP-1 DNA binding activity in PC12 cells
64. Sp-1 binds promoter elements regulated by the RB protein and Sp1-mediated transcription is stimulated by RB co-expression
65. Specific inhibition of myelination by lead in vitro; comparison with arsenic, thallium, and mercury
66. Developmental exposure to lead interferes with glial and neuronal differential gene expression in the rat cerebellum
67. Modulation of developmental cerebellar ornithine decarboxylase activity by lead-acetate
68. Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression
69. Disruption of the zinc finger domain: A common target that underlies many of the effects of lead