Arginine: New and Exciting Developments for an "Old" Amino Acid

Biomedical and Environmental Sciences

Volumn 9, Issue 2-3, 1996, Pages 296-315

  Beaumier, Louis ^a   Castillo, Leticia ^b   Yu, Yong Ming ^c   Ajami, Alfred M ^a   Young, Vernon R ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Shriners Burns Institute   (United States)

^c MassTrace   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NITRIC OXIDE; PROTEIN;

HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; METABOLISM; NUTRITIONAL REQUIREMENT; PHYSIOLOGY; PROTEIN SYNTHESIS; REVIEW;

ARGININE; HOMEOSTASIS; HUMANS; IMMUNE SYSTEM; NITRIC OXIDE; NUTRITIONAL REQUIREMENTS; PROTEIN BIOSYNTHESIS; PROTEINS;

EID: 0030229551     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. Albina, J. E., Mills, C. C., Barbul, A., Thirkill, C. E., Henry, W. L., Jr., Mastrofrancesco, B., and Caldwell, M. D. (1988). Arginine metabolism in wounds. Am. J. Physiol. 254, E459-E467.
2. Alonso, E. and Rubio, V. (1989). Participation of ornithine amino transferase in the synthesis and catabolism of ornithine in mice. Studies using gabaculine and arginine deprivation. Biochem. J. 259, 131-138.
3. Barbul, A. (1986). Arginine, biochemistry, physiology and therapeutic implications. J. Parenter. Enteral. Nutr. 259, 131-138.
4. Barbul, A. (1990). Physiology and pharmacology and arginine. In Nitric Nitric Oxide from L-arginine: A Bioregulatory System (S. Moncada and E. A. Higgs Eds.), pp. 317-329. Excerpta Media, Amsterdam.
5. Barbul, A. and Hurson, M. (1994). Arginine. In Nutrition in Critical Care (G. P. Zaloga Ed.), pp. 107-121. St. Louis, MO: Mosley-Year Book, Inc., St. Louis, Missouri.
6. Beaumier, L., Castillo, L., Ajami, A. M., and Young, V. R. (1995). Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans. Am. J. Physiol. 269, E884-E896.
7. Berthold, H. K., Reeds, R. J., and Klein, P. D. (1995). Isotopic evidence for the differential regulation of arginine and proline synthesis in man. Metabolism 44, 466-473.
8. Billiar, T. R. (1995). Nitric Oxide. Novel biology with clinical relevance. Ann. Surg. 221, 339-349.
9. Brusilow, S. W. (1984). Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis. J. Clin. Invest. 74, 2144-2148.
10. Brusilow, S. W. and Horwich, A. L. (1995). Urea cycle enzymes. In The Metabolic Basis of Inherited Diseases (C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle Eds.), pp. 1187-1232. McGraw-Hill, New York.
11. Burns, R. A., Milner, J. A., and Corbin, J. E. (1981), Arginine: an indispensable amino acid for mature dogs. J. Nutr. 111, 1020-1024.
12. Carey, G. P., Kime, Z., Rogers, Q. R., Morris, J. G., Hargrove, D., Buffington, C. A., and Brusilow, S. W. (1987). An arginine-deficient diet in humans does not evoke hyperammonemia or orotic acidemia. J. Nutr. 117, 1734-1739.
13. Castillo, L., Chapman, T. E., Sanchez, M., Yu, Y-M, Burke, J. F., Ajami, A., Vogt, J., and Young, V. R. (1993a). Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc. Natl. Acad. Sci. USA 90, 7749-7753.
14. Castillo, L., Chapman, T. E., Yu, Y-M, Ajami, A., Burke, J. F., and Young V. R. (1993b). Dietary arginine uptake by the splanchnic region in adult humans. Am. J. Physiol. 265, E532-E539.
15. Castillo, L., DeRojas, T. C., Chapman, T. E., Vogt, J., Burke, J. F., Tannenbaum, S. R., and Young V. R. (1993c). Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Proc. Natl. Acad. Sci. USA 90, 193-197.
16. Castillo, L., Sanchez, M., Chapman, T. E., Ajami, A., Burke, J. F., and Young, V. R. (1994a). The plasma flux and oxidation rate of ornithine adaptively decline with restricted arginine intake. Proc. Natl. Acad. Sci. USA 91, 6393-6397.
17. Castillo, L., Ajami, A., Branch, S., Chapman, T. E., Yu, Y-M, Burke, J. F., and Young V. R. (1994b). Plasma arginine kinetics in adult man: response to an arginine free diet. Metabolism 43, 114-122.
18. Castillo, L., Sanchez, M., Vogt, J., Chapman, T. E., DeRogas-Walker, T. C., Tannenbaum, S. R., Ajami, A. M., and Young V. R. (1995). Plasma arginine, citrulline and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am. J. Physiol. 268, E360-E367.
19. Cheung, C-W, Cohen, N. S., and Raijman, L. (1989). Channeling of urea cycle intermediates in situ in permeabilized hepatocytes. J. Biol. Chem. 264, 4038-4044.
20. Chipponi, J. X., Bleier, J. C., Santi, M. T., and Rudman, D. (1982). Deficiencies of essential and conditionally essential nutrients. Am. J. Clin. Nutr. 35, 1112-1116.
21. Ciechanover, A. and Schwartz, A. L. (1994). The ubiquitin-mediated pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins. FASEB J. 8, 182-191.
22. Cooke, J. P., Singer, A. H., Zera, P., Rowan, R. A., and Billingham, M. E. (1992). Antiatherogenesis effects of L-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 90, 1168-1172.
23. Creager, M. A., Gallagher, S. J., Girerd, X. J., Coleman, S. M., Dzau, V. J., and Cooke, J. P. (1992). L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90, 1248-1253.
24. Cynober, L., LeBoucher, J., and Vasson, M-P. (1995). Arginine metabolism in mammals. J. Nutr. Biochem. 6, 402-413.
25. Davis, T. A., Fiorotto, M. L., and Reeds, P. J. (1993). Amino acid compositions of body and milk protein change during the suckling period in rats. J. Nutr. 123, 947-956.
26. Dhanakoti, S. N., Brosnan, J. T., Herzberg, G. R., and Brosnan, M. E. (1990). Renal arginine synthesis: studies in vitro and in vivo. Am. J. Physiol. 259, E437-E442.
27. Fink, M. P. (Ed.) (1995). Nitric Oxide. New Horizons 3, 1-138
28. nd ed.), p. 377. James & Bartlett Publishers, Inc., Boston.
29. Furchgott, R. F. and Zawadzki, J. V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 228, 373-376.
30. Green, L. C., Ruiz de Luzuriaga, K., Wagner, D. A., Rand, W., Istfan, N., Young, V.R., and Tannenbaum, S. R. (1981). Nitrate biosynthesis in man. Proc. Natl. Acad. Sci. USA, 78, 7764-7768.
31. Grillo, M. (1985). Metabolism and function of polyamines. Int. J. Biochem. 17, 943-948.
32. Hasselgren, P-O, Pedersen, P., Sax, H. C., Warner, B. W., and Fischer, J. E. (1988). Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch. Surg. 123, 992-999.
33. Hussinger, D. (1990). Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem. J. 267, 281-290.
34. Hecker, M., Sessa, W. C., Harris, H. J., Anggard, E. E., and Vane, J. R. (1990). The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. USA 87, 8612-8616.
35. Hedin, S. G. (1895). Veber die Bildung von arginine aus proteinkorper. Z. Physiol. Chem. 21, 155-168.
36. Hoogenraad, N., Totino, N., Elmer, H., Wraight, C., Alewood, P., and Johns, R. B. (1985). Inhibition of intestinal citrulline synthesis causes serve growth retardation in rats. Am. J. Physiol. 249, G792-G799.
37. Hurwitz, R. and Kretchmer, N. (1986). Development of arginine-synthesizing enzymes in mouse intestine. Am. J. Physiol. 251, G103-G110.
38. Inoue, Y., Bode, B. P., Beck, D. J., Li, A. P., Bland, K. I., and Souba, W. W. (1993). Arginine transport in human liver. Characterization and effect of nitric oxide synthase inhibitors. Ann. Surg. 218, 350-363.
39. Kerwin, J. F., Lancaster, J. R., Jr., and Feldman, P. L. (1995). Nitric oxide: A new paradigm for second messengers. J. Medicinal Chem. 38, 4343-4362.
40. Ketteler, M., Barder, W. A., and Noble, N. A. (1994). Cytokines and L-arginine in renal injury and repair. Am. J. Physiol. 267, F197-F207.
41. Kilbourn, R. G. and Griffith, O. W. (1992). Overproduction of nitric oxide in cytokine-mediated and septic shock. J. Nat. Cancer Inst. 84, 827-831.
42. Kharatonov, S. A., Lubec, G., Lubec, B., Hjelm, M., and Barnes, P. J. (1995). L-arginine increases exhaled nitric oxide in normal human subjects. Clin. Sci. 88, 135-139.
43. Kinney, J. M. and Elwyn, D. H. (1986). Protein metabolism and injury. Ann. Rev. Nutr. 3, 433-466.
44. Laidlaw, S. A. and Kopple, J. D. (1987). Newer concepts of the indispensable amino acids. Am. J. Clin. Nutr. 46, 593-605.
45. Leaf, C. D., Wishnok, J. S., and Tannenbaum, S. R. (1990). Nitric oxide: the dark side. In Nitric Oxide from L-Arginine: A Bioregulatory System (S. Moncada and E. A. Higgs, Eds.), pp. 291-299. Elsevier science Publishers B. V. (Biomedical Division), Amsterdam.
46. McCormack, S. A. and Johnson, L. R. (1991). Role of polyamines in gastrointestinal mucosal growth. Am. J. Physiol. 260, G795-G806.
47. Meijer, A. J., Lamers, W. H., and Chamuleau, R. A. (1990). Nitrogen metabolism and ornithine cycle function. Physiol. Rev. 70, 701-748.
48. Moncada, S. and Higgs, E. A. (1993). The L-arginine-nitric oxide pathway. New Engl J. Med. 329, 2002-2012.
49. Morris, J. G. (1985). Nutritional and metabolic responses to arginine deficiency in carnivores. J. Nutr. 115, 524-531.
50. Morris, S. M., Jr. (1992). Regulation of enzymes of urea and arginine synthesis. Annu. Rev. Nutr. 12, 81-101.
51. Morris, S. M., Jr. and Billiar, T. R. (1994). New insights into the regulation of inducible nitric oxide synthesis. Am. J. Physiol. 266, E829-E839.
52. Munro, H. H. (1983). Metabolic basis of nutritional care in liver and kidney disease. In Nutritional Support of the Seriously III Patient (R. W. Winters and H. L. Greene, Eds.), pp. 93-105. Academic Press, Inc., New York.
53. Narita, I., Border, W. A., Ketteler, M., Ruoslahti, E., and Noble, N. A. (1995). L-arginine may mediate the therapeutic effects of low protein diets. Proc. Natl. Acad. Sci. USA 92, 4552-4556.
54. Nettleton, J. A. and Hegsted, D. M. (1974). Reutilization of guanido-labeled arginine in rat liver proteins and the influence of diet. J. Nutr. 104, 916-921.
55. Newsholme, E. A., Crabtree, B., and Ardawi, M. S. (1985). Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q. J. Exp. Physiol. 70, 473-489.
56. Palmer, R. M. (1993). The discovery of nitric oxide in the vessel wall. A unifying concept: the pathogenesis of sepsis. Arch. Surg. 128, 396-401.
57. Park, K.G. (1993). The immunological and metabolic effects of L-arginine in human cancer. Proc. Nutr. Soc. (UK) 52, 387-401.
58. Reyes, A. A., Karl, I. E., and Klahr, S. (1994). Role of arginine in health and in renal disease. Am. J. Physiol. 261, F331-F346.
59. Rose, W. C. (1957). The amino acid requirements of adult man. Nutr. Abstr. Rev. 27, 631-647.
60. Schulze, E. and Steiger, E. (1886). Veber das arginin. Z. Physiol. Chem. 11, 43-65.
61. Sessa, W. C., Hecker, M., Mitchell, J. A., and Vane, J. R. (1990). The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc. Natl. Acad. Sci. USA 87, 8607-8611.
62. Sivaram, P. and Deutscher, M. P. (1990). Existence of two forms of rat liver arginyl-tRNA for synthesis suggest channeling of aminoacyl-tRNA for protein synthesis. Proc. Natl. Acad. Sci. USA 87, 3665-3669.
63. Snyderman, S. E., Boyer, A., and Holt, L. E., Jr. (1959). The arginine requirement of the infant. A. M. A. J. Dis. Child. 97, 192-195.
64. Sörensen, S. P. L. (1910). Veber die synthese des dl-arginins (α-amino-δ-guanidino-η-valeriansaure) und der isomeren δ-guanidino-α-amino-n-valeriansaure. Ber. 43, 643-651.
65. Stamler, J. S., Singel, D. J., and Loscalzo, J. (1992). Biochemistry of nitric oxide and its redox-activated forms. Science 258, 1898-1902.
66. Stapulionis, R. and Deutscher, M. P. (1995). A channeled tRNA cycle during mammalian protein synthesis. Proc. Natl. Acad. Sci. USA 92, 7158-7161.
67. Stephen, J. M. L. and Waterlow, J. C. (1966). Use of carbon-14-labeled arginine to measure the catabolic rate of serum and liver proteins and the extent of amino acid recycling. Nature 211, 978-980.
68. Tizianello, A., DeFerrari, G., Ganibotto, G., Guerreri, G., and Robaudo, C. (1980). Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J. Clin. Invest. 65, 1162-1173.
69. Valle, D. and Simell, O. (1995). The hyperornithenemies. In The Metabolic Basis of Inherited Disease, Vol. 1 (C. R. Scriver, A. L. Beaudet, W. S. Sly and D. Valle Eds.), pp. 1147-1186. New York: McGraw-Hill.
70. Visek, W. J. (1986). Arginine needs, physiological state and usual diets: A reevaluation J. Nutr. 116, 36-46.
71. 3] into nitrate is enhanced by endotoxin treatment. Proc. Natl. Acad. Sci. USA 80, 4518-4521.
72. Wakabayashi, Y., Yamada, E., Yoshida, T., and Takahashi, H. (1994). Arginine becomes an essential amino acid after massive resection of rat small intesine. J. Biol. Chem. 269, 32667-32671.
73. Waterlow, J. C. (1995). Whole-body protein turnover in humans-past, present and future. Annu. Rev. Nutr. 15, 57-92.
74. Waterlow, J. C., Garlick, P. J., and Millward, D. J. (1978). Protein Turnover in Mammalian Tissues and in the Whole Body, 804 pages. Amsterdam: North Holland.
75. Welch, G. R., Kaleti, T., and Vertessy, B. (1988). The control of cell metabolism for homogeneous vs. heterogeneous enzyme systems. J. Theor. Biol. 130, 407-422.
76. Wolfe, R. R., Jahoor, F., and Hartl, W. H. (1989). Protein and amino acid metabolism after injury. Diabetes Metabol Rev. 5, 149-164.
77. 2H as probes. In New Techniques in Nutritional Research (R. Whitehead and A. Prentice Eds.), pp. 17-72. Academic Press, Inc., San Diego.
78. Yu, Y-M, Young, V. R., Castillo, L. C., Chapman, T. E., Tompkins, R. G., Ryan, C. M., and Burke, J. F. (1995a). Plasma arginine and leucine kinetics and urea production rates in burn patients. Metabolism 44, 659-666.
79. Yu, Y-M, Ryan, C. M., Burke, J. F., Tompkins, R. G., and Young, V. R. (1995b). Relations among arginine, citrulline, ornithine and leucine kinetics in adult burn patients. Am. J. Clin. Nutr. 62, 960-968.
80. Yu, Y-M, Sheridan, R. L., Burke, J. F., Chapman, T. E., Tompkins, R. G., and Young, V. R. (1996). The kinetics of plasma arginine and leucine in pediatric burn patients. Am. J. Clin. Nutr. (in press).
81. Zieve, L. (1986). Conditional deficiencies of ornithine or arginine. J. Am. Coll. Nutr. 5, 167-176.