A preliminary randomized study of growth hormone administration in Becker and Duchenne muscular dystrophies

European Heart Journal

Volumn 24, Issue 7, 2003, Pages 664-672

  Cittadini, Antonio ^a   Comi, Lucia Ines ^b   Longobardi, Salvatore ^a   Petretta, Vito Rocco ^b   Casaburi, Cosma ^a   Passamano, Luigia ^b   Merola, Bartolomeo ^a   Durante Mangonid, Emanuele ^b   Politano, Luigi Saccà Luisa ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Cytokines; Growth hormone; X linked muscular dystrophy

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CYTOKINE; HUMAN GROWTH HORMONE; INTERLEUKIN 6; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BECKER MUSCULAR DYSTROPHY; BLOOD PRESSURE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DUCHENNE MUSCULAR DYSTROPHY; HEART ARRHYTHMIA; HEART DILATATION; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HUMAN; LUNG FUNCTION TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKELETAL MUSCLE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; CARDIOMEGALY; CHILD; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; HEART DISEASES; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; LUNG; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; NATRIURETIC PEPTIDE, BRAIN; REGRESSION ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0345700362     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0195-668X(02)00740-6     Document Type: Article

References (27)

1. Perloff KJ. Neurological disorders and heart disease. In: Braunwald E, editor. Heart disease. Philadelphia: WB Saunders; 1997, p. 1865-86.
2. Nigro G, Comi LI, Politano L. The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy. Int J Cardial 1990;26:271-7.
3. Nigro G, Comi LI, Politano L et al. Evaluation of the cardiomyopathy in Becker muscular dystrophy. Muscle Nerve 1995;18:283-91.
4. Saccà L, Cittadini A, Fazio S. Growth hormone and the heart. Endocr Rev 1994;15:555-73.
5. Cittadini A, Stroemer H, Katz SE et al. Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat: a combined in vivo and in vitro evaluation. Circulation 1996;93:800-9.
6. Cittadini A, Grossmann JD, Napoli R et al. Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocardial infarction. J Am Coll Cardiol 1997;29:1109-16.
7. Samarel AM. IGF-1 overexpression rescues the failing heart. Circ Res 2002;90:631-3.
8. Fazio S, Sabatini D, Capaldo B et al. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med 1996;334:809-14.
9. Osterziel KJ, Strohm O, Schuler J et al. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet 1998;351:1233-7.
10. Isgaard J, Bergh CH, Caidahl K et al. A placebo-controlled study of growth hormone in patients with congestive heart failure. Eur Heart J 1998;19:1704-11.
11. Rifai Z, Welle S, Moxley RT III et al. Effect of prednisone on protein metabolism in Duchenne dystrophy. Am J Physiol 1995;268:E67-74.
12. 2+ release channels (ryanodine receptors) and enhances cardiac function in cardiomyopathic hamsters. Cardiovasc Res 1998;40:64-73.
13. Ryoke T, Gu Y, Mao L et al. Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. Circulation 1999;100:1734-43.
14. Maeda K, Tsutamoto T, Wada A et al. High levels of plasma brain natriuretic peptide and interteukin-6 after optimized treatment for heart failure are independent risks factors for moribidity and mortality in patients with congestive heart failure. J Am Coll Cardiol 2000;36:1587-93.
15. Politano L, Nigro V, Petretta VR et al. Development of cardiomyopathy in female carriers of Duchenne and Becker muscular dystrophies. JAMA 1996;275:1335-8.
16. Ghigo E, Bellone J, Aimaretti G et al. Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children. J Clin Endocrinol Metab 1996;81:3323-7.
17. Merota B, Cittadini A, Colao A et al. Cardiac structural and functional abnormalities in GH-deficient adults. J Clin Endocrinol Metab 1993;77:1658-61.
18. Lown B, Wolf M. Approaches to sudden death from coronary heart disease. Circulation 1971;44:130-42.
19. Sahn DJ, DeMaria A, Kissto J et al. The Committee on M-mode standardization of the American Society of Echocardiography: recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58:1072-83.
20. Johannsson G, Grimby G, Sunnerhagen KS et al. Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. J Clin Endocrinol Metab 1997;82:2877-84.
21. Mann DL. Mechanisms and models in heart failure. A combinatorial approach. Circulation 1999;100:999-1008.
22. Saito K, Kobayashi D, Komatsu M et al. A sensitive assay of tumor necrosis factor α in sera from Duchenne muscular dystrophy patients. Clin Chem 2000;46:1703-4.
23. Bergad PL, Schwarzenberg SJ, Humbert JT et al. Inhibition of growth hormone action in models of inflammation. Am J Physiol Cell Physiol 2000;279:C1906-17.
24. Sesmilo G, Biller BM, Llevadot J et al. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. Ann Intern Med 2001;133:111-22.
25. Zatz M, Betti RT, Levy JA. Benign, Duchenne muscular dystrophy in a patient with growth hormone deficiency. Am J Med Genet 1981;10:301-4.
26. Merlini L, Granata C, Ballestrazzi A et al. Growth hormone evaluation in Duchenne muscular dystrophy. Ital J Neurol Sci 1988;9:471-5.
27. Collipp PJ, Kelemen J, Chen SY et al. Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy. J Med Genet 1984;21:254-6.