Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 2877-2884

  Johannsson, Gudmundur ^a   Grimby, Gunnar ^a   Sunnerhagen, Katharina Stibrant ^a   Bengtsson, Bengt Åke ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; KNEE FUNCTION; MAJOR CLINICAL STUDY; MALE; MUSCLE FATIGUE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; PRIORITY JOURNAL; SEX DIFFERENCE;

ADULT; AGED; COHORT STUDIES; FEMALE; GROWTH HORMONE; HAND STRENGTH; HUMANS; ISOMETRIC CONTRACTION; LEG; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; RECOMBINANT PROTEINS; REFERENCE VALUES; SEX CHARACTERISTICS; TIME FACTORS;

EID: 0030882826     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.9.2877     Document Type: Article

References (46)

1. Cuneo RC, Salomon F, Wiles CM, Sönksen PH. 1990 Skeletal muscle performance in adults with growth hormone deficiency. Horm Res. 33(Suppl 4):55-60.
2. Rutherford OM, Jones DA, Round JM, Preece MA. 1989 Changes in skeletal muscle after discontinuation of growth hormone treatment in young adults with hypopituitarism. Acta Paediatr Scand. [Suppl] 356:61-63.
3. Rutherford OM, Beshyah SA, Schott J, Watkins Y, Johnston DG. 1995 Contractile properties of the quadriceps muscle in growth hormone-deficient hypopituitary adults. Clin Sci. 88:67-71.
4. Beshyah SA, Freemantie C, Shahi M, et al. 1995 Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults. Clin Endocrinol (Oxf). 42:73-84.
5. Rutherford OM, Beshyah SA, Johnston DG. 1994 Quadriceps strength before and after growth hormone replacement in hypopituitary adults: relationship to changes in lean body mass and IGF-1. Endocrinol Metab. 1:41-47.
6. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol. 70:688-694.
7. Ayling CM, Moreland BH, Zanelli JM, Schulster D. 1989 Human growth hormone treatment of hypophysectomized rats increases the proportion of type-1 fibres in skeletal muscle. J Endocrinol. 123:429-435.
8. Whitehead HM, Gilliland JS, Allen IV, Hadden DR. 1989 Growth hormone treatment in adults with growth hormone deficiency: effects on muscle fiber size and proportions. Acta Paediatr Scand. [Suppl] 356:65-67.
9. Cuneo RC, Salomon F, Wiles CM, et al. 1992 Histology of skeletal muscle in adults with GH deficiency: comparison with normal muscle and response to GH treatment. Horm Res. 37:23-28.
10. Crist DM, Peake GT, Egan PA, Waters DL. 1988 Body composition response to exogenous GH during training in highly conditioned adults. J Appl Physiol. 65:579-584.
11. Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM. 1992 Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol. 262:E261-E267.
12. Yarasheski KE, Zachwieja JJ, Campbell JA, Bier DM. 1995 Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol. 268:E268-E276.
13. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med. 323:1-6.
14. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol. 70:695-700.
15. Caidahl K, Edén S, Bengtsson B-Å. 1994 Cardiovascular and renal effects of growth hormone. Clin Endocrinol (Oxf). 40:393-400.
16. Nagulesparen M, Trickey R, Davies MJ, Jenkins JS. 1976 Muscle changes in acromegaly. Br Med J. 2:914-915.
17. Larsson L, Grimby G, Karlsson J. 1979 Muscle strength and speed of movement in relation to age and muscle morphology. J Appl Physiol. 46:451-456.
18. Borges O. 1989 Isometric and isokinetic knee extension and flexion torque in men and women aged 20-70. Scand J Rehab Med. 21:45-53.
19. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. 1994 Serum insulin-like growth factor I in a random population sample of men and women: relationship to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol (Oxf). 41:351-357.
20. Aniansson A, Grimby G, Rundgren Å. 1980 Isometric and isokinetic quadriceps muscle strength in 70-year-old men and women. Scand J Rehab Med. 12:161-168.
21. Nordenskjöld UM, Grimby G. 1993 Grip force in patients with rheumatoid arthritis and fibromyalgia and in healthy subjects. A study with Grippit instrument. Scand J Rheumatol. 22:14-19.
22. Thorstensson A, Karlsson J. 1976 Fatiguability and fibre composition of human skeletal muscle. Acta Physiol Scand. 98:318-322.
23. Rutherford OM, Jones DA, Newham DJ. 1986 Clinical and experimental application of the percutaneous twitch superimposition technique for the study of human muscle activation. J Neurol Neurosurg Psychol. 49:1288-1291.
24. Thomeé R, Grimby G, Svantesson U, Österberg U. 1996 Quadriceps muscle performance in sitting and standing in young women with patellofemoral pain syndrome and healthy women. Scand J Med Sci Sports. 6:233-241.
25. Bruce Å, Andersson M, Arvidsson B, Isaksson B. 1980 Body composition. Prediction of normal body potassium, body water and body fat in adults on the basis of body height, body weight and age. Scand J Clin Lab Invest. 40:461-473.
26. Moore FD, Olesen KH, McMurrey JD, Parker HV, Ball MR, Boyden CM. 1963 The body cell mass and its supporting environment: body composition in health and disease. Philadelphia, London: Saunders.
27. Diggle PJ, Liang K-Y, Zeger SL. 1994 Analysis of longitudinal data. In: Atkinson AC, Copas JB, Pierce DA, Schervish MJ, Titterington DM, eds. Oxford statistical science series. Oxford: Oxford University Press.
28. Yarasheski KE. 1994 Growrth hormone effects on metabolism, body composition, muscle mass, and strength. In: Holloszy JO, ed. Exercise and sport sciences reviews. American College of Sports Medicine Ser vol 22. Baltimore: Williams and Wilkins; 285-312.
29. Isgaard J. 1992 Expression and regulation of IGF-I in cartilage and skeletal muscle. Growth Regul. 2:16-22.
30. Grindeland RE, Roy RR, Edgerton VR, et al. 1994 Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol. 267:R316-R322.
31. Jørgensen JOL, Pedersen SA, Thuesen L, et al. 1991 Long-term growth hormone treatment in growth hormone deficient adults. Acta Endocrinol (Copenh). 125:449-453.
32. Sartorio A, Narici M, Conti A, Monzani M, Faglia G. 1995 Quadriceps and hand-grip strength in adults with childhood-onset growth hormone deficiency. Eur J Endocrinol. 132:37-41.
33. Johannsson G, Rosén T, Lindstedt G, Bosaeus I, Bengtsson B-Å. 1996 Effects of 2 years of growth hormone treatment on body composition and cardiovascular risk factors in adults with growth hormone deficiency. Endocrinol Metab. 3(Suppl A):3-12.
34. Degerblad M, Almkvist O, Grunditz R, et al. 1990 Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency. Acta Endocrinol (Copenh). 123:185-193.
35. Whitehead H, Boreman C, McIlrath EM, et al. 1992 Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin Endocrinol (Copenh). 36:45-52.
36. Narici MV, Roi GS, Landoni L, Minetti AE, Cerretelli P. 1989 Changes in force, cross-sectional area and neural activation during strength training and detraining of the human quadriceps. Eur J Appl Physiol. 59:310-319.
37. Maughan RJ, Watson JS, Weir J. 1983 Strength and cross-sectional area of human skeletal muscle. J Physiol. 338:37-49.
38. Bosaeus I, Johannsson G, Rosén T, et al. 1996 Comparison of methods to estimate body fat in growth hormone deficient adults. Clin Endocrinol (Oxf). 44:395-402.
39. Behm DG, St-Pierre DMM, Perez D. 1996 Muscle inactivation: assessement of interpolated twitch technique. J Appl Physiol. 81:2267-2273.
40. Johannsson G, Bjarnason R, Bramnert M, et al. 1996 The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH binding protein, body mass index, age and gender. J Clin Endocrinol Metab, 81:1575-1581.
41. Papadakis MA, Grady D, Black D, et al. 1996 Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med. 124:708-716.
42. Taaffe DR, Pruitt L, J. R, et al. 1994 Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab. 79:1361-1366.
43. Burke RE, Levine ND, Zajac III FE, Tsairis P, Engel WK. 1971 Mammalian motor units: physiological-histochemical correlation in three types in cat gastrocnemicus. Science. 174:709-712.
44. Rosén T, Wirén L, Wilhelmsen L, Wiklund I, Bengtsson B-Å. 1994 Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf). 40:111-116.
45. Burman P, Broman JE, Hetta J, et al. 1995 Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab. 80:3585-3590.
46. DeVol DL, Rotwein P, Sadow JL, Novakofski J, Bechtel PJ. 1990 Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am J Physiol. 259:E89-E95.