Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 9, 1996, Pages 3323-3327

  Ghigo, E ^a   Bellone, J ^a   Aimaretti, G ^a   Bellone, S ^a   Loche, S ^b   Cappa, M ^c   Bartolotta, E ^d   Dammacco, F ^e   Camanni, F ^a,f  

^a UNIVERSITY OF TURIN   (Italy)

^b Microcitellic Hospital   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d Hospital of Recanati   (Italy)

^e POLICLINICO   (Italy)

^f MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CHOLINESTERASE INHIBITOR; CLONIDINE; GLUCAGON; GROWTH HORMONE RELEASING FACTOR; LEVODOPA; PYRIDOSTIGMINE;

ADOLESCENT; ARTICLE; CHILD; ENZYME INHIBITION; EXERCISE; FEMALE; GROWTH HORMONE RELEASE; GROWTH RATE; HORMONE DETERMINATION; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RELIABILITY; SHORT STATURE; SOMATIC CELL GENETICS;

ADOLESCENT; ARGININE; CHILD; CHILD, PRESCHOOL; CLONIDINE; EXERCISE; FEMALE; GLUCAGON; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; HYPOGLYCEMIA; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEVODOPA; MALE; PYRIDOSTIGMINE BROMIDE; REPRODUCIBILITY OF RESULTS;

EID: 0029815429     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.9.3323     Document Type: Article

References (26)

1. Frasier SD. 1974 A review of growth hormone stimulation tests in children. Pediatrics. 53:929-936.
2. Underwood LE, Van Wyk JJ. 1992 Normal and aberrant growth. In: Wilson J.D., Foster D.W, eds. Williams textbook of endocrinology. Philadelphia: Saunders; 1079-1138.
3. Rosenfeld RG, Albertsson-Wikland K, Cassorla F, et al. 1995 Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab. 80:1532-1540.
4. Borges JLC, Blizzard RM, Gelato MC, et al. 1983 Effect of human pancreatic tumor GH-releasing factor on GH and somatomedin levels in patients with idiopathic GH deficiency. Lancet. 2:119-122.
5. Grossman A, Savage MO, Wass JAH, et al. 1983 GH-releasing factor in GH deficiency: demonstration of a hypothalamic defect in GH release. Lancet. 2:137-140.
6. Vance ML, Borges JLC, Kaiser DL, et al. 1984 Human pancreatic tumor growth hormone-releasing factor (hp GRF-40): dose-response relationship in normal man. J Clin Endocrinol Metab. 58:838-845.
7. Mazza E, Ghigo E, Goffi S, et al. 1989 Effects of the potentiation of cholinergic activity on the variability in individual GH response to GHRH. J Endocrinol Invest. 12:795-798.
8. Massara F, Ghigo E, Demislis K, et al. 1986 Cholinergic involvement in the GHRH-induced GH release. Studies in normal and acromegalic subjects. Neuroendocrinology. 43:670-675.
9. Ghigo E, Bellone J, Mazza E, et al. 1990 Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children. Further evidence for a somatostatin suppressing effect of arginine. Clin Endocrinol (Oxf). 32:70-74.
10. Ghigo E, Imperiale E, Boffano GM, et al. 1990 A new test for diagnosis of GH deficiency due to primary pituitary impairment: combined administration of pyridostigmine and GHRH. J Endocrinol Invest. 13:307-316.
11. Dammacco F, Boghen MF, Camanni F, et al. 1993 Somatotropic function in short stature: evaluation by integrated auxological and hormonal indices in 214 children. J Clin Endocrinol Metab. 77:68-72.
12. Zadik A, Chalew A, Kowarski A. 1990 Assessment of growth hormone secretion in normal stature children using 24-hour integrated concentration of GH and pharmacological stimulation. J Clin Endocrinol Metab. 71:932-936.
13. Marin G, Domené HM, Barnes KM, Blackwell BJ, Cassorla FG, Cutler Jr GB. 1994 The effect of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab. 79:537-541.
14. Moretti C, Fabbri A, Gnessi L, et al. 1983 Naloxone inhibits exercise-induced release of prolactin and GH in athletes. Clin Endocrinol 8:135-138.
15. Muller EE, Nisticò G, eds. 1989 Brain messengers and the pituitary. San Diego: Academic Press.
16. Dieguez C, Page MD, Scanlon F. 1988 Growth hormone neuroregulation and its alterations in disease states. Clin Endocrinol (Oxf). 28:109-143.
17. Devesa J, Lima L, Lois N, et al. 1989 Reasons for the variability in growth hormone (GH) responses to GHRH challenge: the endogenous hypothalamic-somatotroph rhythm (HSR). Clin Endocrinol (Oxf). 30:367-77.
18. Rogol AD, Blizzard RM, Johanson AJ, et al. 1984 GH release in response to human pancreatic tumor GHRH-40 in children with short stature. J Clin Endocrinol Metab. 99:580-586.
19. Chalew SA, Armour KM, Levine PA, Thorner MO, Kowarski AA. 1986 GH response to GHRH in children with subnormal integrated concentrations of GH. J Clin Endocrinol Metab. 62:1110-1115.
20. Gelato MC, Malowzoski S, Caruso-Nicoletti M, et al. 1986 GH response to GHRH during pubertal development in normal boys and girls: comparison to idiopathic short stature and GH deficiency. J Clin Endocrinol Metab. 63:174-180.
21. Locatelli V, Torsello A, Redaelli M, Ghigo E, Massara F, Muller EE. 1986 Cholinergic agonist and antagonist drugs modulate in the rat the growth hormone response to growth hormone releasing hormone. Evidence for mediation by somatostatin. J Endocrinol. 111:271-278.
22. Cappa M, Loche S, Salvadori R, et al. 1991 The GH response to pyridostigmine plus GHRH is not influenced by pubertal maturation. J Endocrinol Invest. 14:41-45.
23. Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu B. 1984 Growth hormone neurosecretory dysfunction. A treatable cause of short stature. JAMA. 251:2223-2230.
24. Zadik Z, Chalew SA, Raiti S, Kowarsky AA. 1985 Do short children secrete insufficient growth hormone? Pediatrics. 76:355-360.
25. Bercu BB, Shulman D, Root AW, Spiliotis BE. 1985 Growth hormone (GH) provocative testing frequently does not reflect GH secretion. J Clin Endocrinol Metab. 63:709-713.
26. Rose SR, Ross JL, Uriarte M, Barnes KM, Cassorla FG, Cutler GB. 1988 The advantage of measuring stimulation as compared with spontaneous GH levels in the diagnosis of GH deficiency. N Engl J Med. 319:201-207.