Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: Investigations using the selective inhibitors, 1400W and celecoxib

British Journal of Pharmacology

Volumn 125, Issue 2, 1998, Pages 335-340

  Hamilton, Lorna C ^a   Warner, Timothy D ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

1400W; Celecoxib; Cyclo oxygenase 2; Lipopolysaccharide; Nitric oxide; Nitric oxide synthase; Prostanoids; Rat

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DICLOFENAC; LIPOPOLYSACCHARIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) METHYLARGININE; NITRATE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; TERIFLUNOMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

6-KETOPROSTAGLANDIN F1 ALPHA; AMIDINES; ANALYSIS OF VARIANCE; ANILINE COMPOUNDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZYLAMINES; CYCLOOXYGENASE 2; DEXAMETHASONE; DICLOFENAC; ENZYME INHIBITORS; HYDROXYBUTYRATES; ISOENZYMES; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; NITROGEN DIOXIDE; OMEGA-N-METHYLARGININE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, WISTAR; SULFONAMIDES;

EID: 0031720227     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702077     Document Type: Article

References (39)

1. AMIN, A.R., ATTUR, M., PATEL, R.N., THAKKER, G.D., MARSHALL, P.J., REDISKE, J., STUCHIN, S.A., PATEL, I.R. & ABRAMSON, S.B. (1997). Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J. Clin. Invest., 99, 1231-1237.
2. BAYDOUN, A.R., BOGLE, R.G., PEARSON, J.D. & MANN, G.E. (1993). Arginine uptake and metabolism in cultured murine macrophages. Agents Actions, 38, C127-129.
3. BISHOP-BAILEY, D., LARKIN, S.W., WARNER, T.D., CHEN, G. & MITCHELL, J.A. (1997). Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture. Br. J. Pharmacol., 121, 125-133.
4. CORBETT, J.A., KWON, G., TURK, J. & MCDANIEL, M.L. (1993). IL-1β induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Biochemistry, 32, 13767-13770.
5. DELA TORRE, A., SCHROEDER, R.A. & KUO, P.C. (1997). Alteration of NF-kappa B P50 binding kinetics by S-nitrosylation. Biochem. Biophys. Res. Commum., 238, 703-706.
6. FLOWER, R.J. (1988). Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br. J. Pharmacol., 94, 987-1015.
7. FRANCHI, A.M., CHAUD, M., RETTORI, V., SUBURO, A., MCCANN, S.M. & GIMENO, M. (1994). Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri. Proc. Natl. Acad. Sci. U.S.A., 91, 539-543.
8. FRANTZ, B. & O'NEILL, E.A. (1995). The effect of sodium salicylate and aspirin on NF-κB. Science, 270, 2017-2019.
9. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1996). Effects of dexamethasone and SB 209670 on the regional haemodynamic responses to lipopolysaccharide in conscious rats. Br. J. Pharmacol., 118, 141-149.
10. GARVEY, E.P., OPLINGER, J.A., FURFINE, E.S., KIFF, R.J., LASZLO, F., WHITTLE, B.J. & KNOWLES, R.G. (1997). 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem., 272, 4959-4963.
11. HABIB, A., BERNARD, C., LEBRET, M., CREMINON, C., ESPOSITO, B., TEDGUI, A. & MACLOUF, J. (1997). Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages. J. Immunol., 158, 3845-3851.
12. 1α following administration of exogenous arachidonic acid or bradykinin. Br. J. Pharmacol., 122, 22P.
13. HAMILTON, L.C., TOMLINSON, A., DYE, L.J., MITCHELL, J.A. & WARNER, T.D. (1998). Use of selective enzyme inhibitors provide no evidence for cross-talk between inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-treated rats. Br. J. Pharmacol., 123, 11P.
14. HAMILTON, L.C., VOJNOVIC, I., BAKHLE, Y.S., WARNER, T.D. & VANE, J.R. (1997b). The anti-inflammatory drug leflunomide inhibits in vitro and in vivo the activity of COX-2 more potently than the induction of COX-2 or iNOS. Br. J. Pharmacol., 120, 49P.
15. HULKOWER, K.I., POLLOCK, J.S., WALSH, R.E., HUANG, R., OTIS, E.R., BROOKS, C.D. & BELL, R.L. (1996). Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages. Prostaglandins Leukot. Essent. Fatty Acids, 55, 145-149.
16. 2 production by vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 194, 420-424.
17. KANNER, J., HAREL, S. & GRANIT, R. (1992). Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin. Lipids, 27, 46-49.
18. KENNEDY, T.A., SMITH, C.J. & MARNETT, L.J. (1994). Investigations of the roles of systeines in catalysis by prostaglandin endoperoxide synthase. J. Biol. Chem., 269, 27357-27364.
19. LASZLO, F., EVANS, S.M. & WHITTLE, B.J. (1995). Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur. J. Pharmacol., 272, 169-175.
20. MISKO, T., MOORE, P., KASTEN, W.M., NICKOLS, T.P., CORBETT, J.A., TILTON, R.G., MCDANIEL, M.L., WILLIAMSON, J.R. & CURRIE, M.G. (1993). Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol., 233, 119-125.
21. MONCADA, S. (1997). Nitric oxide in the vasculature: physiology and pathophysiology. Ann. N. Y. Acad. Sci., 811, 60-67.
22. MORIGUCHI, M., MANNING, L.R. & MANNING, J.M. (1992). Nitric oxide can modify amino acid residues in proteins. Biochem. Biophys. Res. Commun., 183, 598-604.
23. PAYA, M., GARCIA, P.P., COLOMA, J. & ALCARAZ, M.J. (1997). Nitric oxide synthase and cyclo-oxygenase pathways in the inflammatory response induced by zymosan in the rat air pouch. Br. J. Pharmacol., 120, 1445-1452.
24. PENNING, T.D., TALLEY, J.J., BERTENSHAW, S.R., CARTER, J.S., COLLINS, P.W., DOCTER S, GRANETO, M.J., LEE, L.F., MALECHA, J.W., MIYASHIRO, J.M., ROGERS, R.S., ROGIER, D.J., YU, S.S., ANDERSON, G.D., BURTON, E.G., COGBURN, J.N., GREGORY, S.A., KOBOLDT, C.M., PERKINS, W.E., SEIBERT, K., VEENHUIZEN, A.W., ZHANG, Y.Y. & ISAKSON, P.C. (1997). Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J. Med. Chem., 40, 1347-1365.
25. PICOT, D., LOLL, P.J. & GARAVITO, R.M. (1994). The x-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature, 367, 243-249.
26. SALVEMINI, D., MISKO, T.P., MASFERRER, J.L., SEIBERT, K., CURRIE, M.G. & NEEDLEMAN. (1993). Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. U.S.A., 90, 7240-7244.
27. SALVEMINI, D., SEIBERT, K., MASFERRER, J.L., MISKO, T.P., CURRIE, M.G. & NEEDLEMAN. (1994). Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J. Clin. Invest., 93, 1940-1947.
28. SALVEMINI, D., SETTLE, S.L., MASFERRER, J.L., SEIBERT, K., CURRIE, M.G. & NEEDLEMAN. (1995). Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br. J. Pharmacol., 114, 1171-1178.
29. SCHMIDT, H.H., WARNER, T.D., NAKANE, M., FORSTERMANN, U. & MURAD, F. (1992). Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol. Pharmacol., 41, 615-624.
30. SCHOEDON, G., SCHNEEMANN, M., HOFER, S., GUERRERO, L., BLAU, N. & SCHAFFNER, A. (1993). Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages. Eur. J. Biochem., 213, 833-839.
31. SEIBERT, K., MASFERRER, J.L., NEEDLEMAN, P. & SALVEMINI, D. (1996). Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br. J. Pharmacol., 117, 1016-1020.
32. STADLER, J., HARBRECHT, B.G., DI SILVIO, M., CURRAN, R.D., JORDAN, M.L., SIMMONS, R.L. & BILLIAR, T.R. (1993). Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J. Leukoc. Biol., 53, 165-172.
33. 6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. Eur. J. Pharmacol., 294, 703-712.
34. SWIERKOSZ, T.A., MITCHELL, J.A., WARNER, T.D., BOTTING, R.M. & VANE, J.R. (1995). Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br. J. Pharmacol, 114, 1335-1342.
35. TAKAHASHI, S., FUTAKI, N., YOKOYAMA, M., YAMAKAWA, Y., ARAI, I., HIGUCHI, S. & OTOMO, S. (1995). Expression of prostaglandin H synthase-2 in endotoxic shock induced in rats. Arch. Int. Pharmacodyn. Ther., 330, 102-115.
36. TETSUKA, T., DAPHNA-IKEN, D., MILLER, B.W., GUAN, Z., BAIER, L.D. and MORRISON, A.R. (1996). Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. J. Clin. Invest., 97, 2051-2056.
37. VAN DER OUERAA, F.J., BUYTENHEK, M., SLIKKERVEER, F.J. and VAN DORP, D.A. (1979). On the haemoprotein character of prostaglandin endoperoxide synthetase. Biochim. Biophys. Acta., 572, 29-42.
38. VANE, J.R., MITCHELL, J.A., APPLETON, I., TOMLINSON, A., BISHOP-BAILEY, D., CROXTALL, J. and WlLLOUGHBY, D.A. (1994). Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A., 91, 2046-2050.
39. WRAY, G.M., MILLAR, C.G., HINDS, C.J. and THlEMERMANN, C. (1998). Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock, in press.