Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: Role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6191-6202

  Peneff, Caroline ^a   Ferrari, Paul ^b   Charrier, Véronique ^b   Taburet, Yvette ^b   Monnier, Célia ^a   Zamboni, Véronique ^a   Winter, Jacques ^b   Harnois, Marzia ^b   Fassy, Florence ^b   Bourne, Yves ^a  

^a Centre National de la Recherche Scientifique   (France)

^b SANOFI   (France)

Author keywords

Alternative splicing; Crystallography; Human enzyme; Oligomeric assembly; UDPGlcNAc pyrophosphorylase

Indexed keywords

PHOSPHORYLASE; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME SYNTHESIS; GENOME; HUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; STRUCTURE ANALYSIS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; ASTROCYTES; BINDING SITES; CARTILAGE; CATALYSIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; EXPRESSED SEQUENCE TAGS; GLYCOSYLATION; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOSACCHARIDE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; UTP-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE;

EID: 17944368066     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6191     Document Type: Article

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