Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: Relating biological consequences to conformational preferences

Nucleic Acids Research

Volumn 31, Issue 20, 2003, Pages 6004-6015

  Schinecker, Thomas M ^a   Perlow, Rebecca A ^a   Broyde, Suse ^a   Geacintov, Nicholas E ^a   Scicchitano, David A ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; BENZO[C]PHENANTHRIDINE DERIVATIVE; CELL DNA; CELL EXTRACT; DNA BASE; EPOXIDE; NUCLEOTIDE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RNA POLYMERASE; RNA POLYMERASE II;

ARTICLE; CARCINOGENICITY; CELL NUCLEUS; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; DNA ADDUCT; DNA CONFORMATION; DNA DAMAGE; DNA FLANKING REGION; DNA MODIFICATION; DNA STRAND; DNA STRUCTURE; DNA TEMPLATE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; EXCISION REPAIR; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; ISOMER; MOLECULAR MODEL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; REACTION ANALYSIS; STEREOCHEMISTRY; TRANS ISOMER; TRANSCRIPTION REGULATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; CATALYTIC DOMAIN; DNA ADDUCTS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; PROTEIN CONFORMATION; RNA POLYMERASE II; TEMPLATES, GENETIC; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0345305415     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg771     Document Type: Article

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