Transcription and DNA damage: A link to a kink

Environmental Health Perspectives

Volumn 105, Issue SUPPL. 1, 1997, Pages 145-153

  Scicchitano, David A ^a   Mellon, Isabel ^b  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Base excision repair; DNA damage; DNA repair; Mismatch repair; Nucleotide excision repair; Transcription

Indexed keywords

NUCLEOTIDE; RNA POLYMERASE;

DNA ADDUCT; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; GENOME; GENOTOXICITY; PRIORITY JOURNAL; REVIEW;

EID: 0030928896     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.97105s1145     Document Type: Review

References (73)

1. Singer B, Grunberger D. Molecular Biology of Mutagens and Carcinogens. New York:Plenum Press, 1983.
2. Friedberg EC, Walker GC, Siede W. DNA Repair and Mutagenesis. Washington:ASM Press, 1995.
3. Hanawalt PC. Transcription-coupled repair and human disease. Science 266:1957-1958 (1994).
4. Sancar A. Mechanisms of DNA excision repair. Science 266:1954-1956 (1994).
5. Lehmann AR. Nucleotide excision repair and the link with transcription. Trends Biochem Sci 20:402-405 (1995).
6. Van Houten B. Nucleotide excision repair in Escherichia coli. Microbiol Rev 54:18-51 (1990).
7. Sakumi K, Sekiguchi M. Structure and function of DNA glycosylases. Mutat Res 236:161-172 (1990).
8. Wallace SS. AP endonucleases and DNA glycosylases that recognize oxidative DNA damage. Environ Mol Mutagen 12:431-477 (1988).
9. Modrich P. Mismatch repair, genetic stability, and cancer. Science 266:1959-1960 (1994).
10. 6-alkylguanine-DNA alkyltransferase: regulation and importance in alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119-6129 (1990).
11. Sancar A. No "end of history" for photolyases. Science 272:48-49 (1996).
12. Hanawalt PC, Mellon I. DNA repair: stranded in an active gene. Curr Biol 3:67-69 (1993).
13. Scicchitano DA, Hanawalt PC. Intragenomic repair heterogeneity of DNA damage. Environ Health Perspect 98:45-51 (1992).
14. Bohr VA, Smith CA, Okumoto DS, Hanawalt PC. DNA repair in an active gene: removal of pyrimidine dimers from the dhfr gene of CHO cells is much more efficient than in the genome overall. Cell 40:359-369 (1985).
15. Mellon I, Bohr VA, Smith CA, Hanawalt PC. Preferential repair of an active gene in human cells. Proc Natl Acad Sci USA 83:8878-8882 (1986).
16. Mellon I, Spivak G, Hanawalt PC. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian dhfr gene. Cell 51:241-249 (1987).
17. Chen R-H, Maher VM, Brouwer J, van de Putte P, McCormick JJ. Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts. Proc Natl Acad Sci USA 89:5413-5417 (1992).
18. Carothers AM, Zhen W, Mucha J, Zhang Y-J, Santella RM, Grunberger D, Bohr VA. DNA strand-specific repair of (±)-3α,4β-dihydroxy-1α,2α-epoxy-1,2,3,4- tetrahydrobenzo[r]phenanthrene adducts in the hamster dihydrofolate reductase gene. Proc Natl Acad Sci USA 89:11925-11929 (1992).
19. Tang MS, Qian M, Pao A. Formation and repair of antitumor antibiotic CC-1065-induced DNA adducts in the adenine phosphoribosyltransferase and amplified dihydrofolate reductase genes of Chinese hamster ovary cells. Biochemistry 33:2726-2732 (1994).
20. Leadon SA, Lawrence DA. Preferential repair of DNA damage on the transcribed strand of the human metallothionein genes requires RNA polymerase II. Mutat Res 255:67-78 (1991).
21. Stevnsner TA, May A, Petersen LN, Larminat F, Pirsel M, Bohr VA. Repair of ribosomal RNA genes in hamster cells after UV irradiation, or treatment with cisplatin or alkylating agents. Carcinogenesis 14:1591-1596 (1993).
22. Leadon SA, Cooper PK. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc Natl Acad Sci USA 90:10499-10503 (1993).
23. Vos J-M, Hanawalt PC. Processing of psoralen adducts in an active human gene: repair and replication of DNA containing monoadducts and interstrand cross-links. Cell 50:789-799 (1987).
24. Islas AL, Baker FJ, Hanawalt PC. Transcription-coupled repair of psoralen cross-links but not monoadducts in Chinese hamster ovary cells. Biochemistry 33:10794-10799 (1994).
25. Scicchitano DA, Hanawalt PC. Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity. Proc Natl Acad Sci USA 86:3050-3054 (1989).
26. Wang W, Sitaram A, Scicchitano DA. 3-Methyladenine and 7-methylguanine exhibit no preferential removal from the transcribed strand of the dihydrofolate reductase gene in Chinese hamster ovary B11 cells. Biochemistry 34:1798-1804 (1995).
27. Tang MS, Bohr VA, Zhang XS, Pierce J, Hanawalt PC. Quantification of aminofluorene adduct formation and repair in defined DNA sequences in mammalian cells using UVRABC nuclease. J Biol Chem 264:14455-14462 (1989).
28. Tang MS, Pao A, Zhang XS. Repair of benzo[a]pyrene diol epoxide-and UV-induced DNA damage in dihydrofolate reductase and adenine phosphoribosyltransferase genes of CHO cells. J Biol Chem 269:12749-12754 (1994).
29. Sweder KS. Nucleotide excision repair in yeast. Curr Genet 27:1-16 (1994).
30. Snow ET. The role of DNA repair in development. Repro Toxicol (in press).
31. Mellon I, Hanawalt PC. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature 342:95-98 (1989).
32. Christians FC, Hanawalt PC, Inhibition of transcription and strand-specific DNA repair by α-amanitin in Chinese hamster ovary cells. Mutat Res 274:93-101 (1992).
33. Christians FC, Hanawalt PC. Lack of transcription-coupled repair in mammalian ribosomal RNA genes. Biochemistry 32:10512-10518 (1993).
34. Sauerbier W, Hercules K. Gene and transcription unit mapping by radiation effects. Annu Rev Genet 12:329-363 (1978).
35. Donahue BA, Yin S, Taylor JS, Reines D, Hanawalt PC. Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc Natl Acad Sci USA 91:8502-8506 (1994).
36. Shi Y, Gamper H, Hearst JE. Interaction of T7 RNA polymerase with DNA in an elongation complex arrested at a specific psoralen adduct site. J Biol Chem 263:527-534 (1988).
37. Shi Y, Gamper H, Hearst JE. The effects of covalent additions of a psoralen on transcription by E. coli RNA polymerase. Nucleic Acids Res 15:6843-6854 (1987).
38. Chen Y-H, Bogenhagen DF. Effects of DNA lesions on transcription elongation by T7 RNA polymerase. J Biol Chem 268:5849-5855 (1993).
39. Chen Y-H, Matsumoto Y, Shibutani S, Bogenhagen DF. Acetylaminofluorene and aminofluorene adducts inhibit in vitro transcription of a Xenopus 5S RNA gene only when located on the coding strand. Proc Natl Acad Sci USA 88:9583-9587 (1991).
40. Choi D-J, Marino-Alessandri DJ, Geacintov NE, Scicchitano DA. Site-specific benzo[a]pyrene diol epoxide-DNA adducts inhibit transcription elongation by bacteriophage T7 RNA polymerase. Biochemistry 33:780-787 (1994).
41. Selby CP, Sancar A. Gene-and strand-specific repair in vitro: partial purification of a transcription-repair coupling factor. Proc Natl Acad Sci USA 88:8232-8236 (1991).
42. Selby CP, Witkin EM, Sancar A. Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor. Proc Natl Acad Sci USA 88:11574-11578 (1991).
43. Lehmann AR. Three complementation groups in Cockayne syndrome. Mutat Res 106:347-356 (1982).
44. Mayne LV, Lehmann AR. Failure of RNA synthesis to recover after UV-irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. Cancer Res 42:1473-1478 (1982).
45. van Hoffen A, Natarajan AT, Mayne LV, van Zeeland AA, Mullenders LHF, Venema J. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res 21:5890-5895 (1993).
46. Troelstra C, Odijk H, de Wit J, Westerveld A, Thompson LH, Bootsma D, Hoeijmakers JHJ. Molecular cloning of the human DNA excision repair gene ERCC-6. Mol Cell Biol 10:5806-5813 (1990).
47. IIH. Cell 82:555-564 (1995).
48. Mellon I, Champe GN. Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli. Proc Natl Acad Sci USA 93:1292-1297 (1996).
49. Cleaver JE, Kraemer KH. Xeroderma pigmentosum. In: The Metabolic Basis of Inherited Disease (Scriver CR, Beaudet AL, Sly WS, Valle D, eds). New York:McGraw Hill Book Co, 1989;2949-2971.
50. Jones CJ, Wood RD. Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA. Biochemistry 32:12096-12104 (1993).
51. Weeda G, van Ham RCA, Masurel R, Westerveld A, Odijk H, de Wit J, Boorsma D, van der Eb AJ, Hoeijmakers JHJ. Molecular cloning and biological characterization of the human excision repair gene ERCC-3. Mol Cell Biol 10:2570-2581 (1990).
52. Legerski R, Peterson C. Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 359:70-73 (1992).
53. Weber CA, Salazar EP, Stewart SA, Thompson LH. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. EMBO J 9:1437-1447 (1990).
54. Weber CA, Salazar EP, Stewart SA, Thompson LH. Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells. Mol Cell Biol 8:1137-1146 (1988).
55. Chu G, Chang E. Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Science 242:564-567 (1988).
56. Thompson LH, Brookman KW, Weber CA, Salazar EP, Reardon JT, Sancar A, Deng Z, Siciliano MJ. Molecular cloning of the human nucleotide excision repair gene ERCC4. Proc Natl Acad Sci USA 91:6855-6859 (1994).
57. O'Donovan A, Wood RD. Identical defects in xeroderma pigmentosum group G and rodent ERCC group 5. Nature 363:185-188 (1993).
58. van Duin M, Vredeveldt G, Mayne LV, Odijk H, Vermeulen W, Klein B, Weeda G, Hoeijmakers JHJ, Bootsma D, Westerveld A. The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I. Mutat Res 217:83-92 (1989).
59. Evans MK, Robbins JH, Ganges MB, Tarone RE, Nairn RS, Bohr VA. Gene-specific DNA repair in xeroderma pigmentosum complementation groups A, C, D, and F. J Biol Chem 268:4839-4847 (1993).
60. Hoeijmakers JHJ. Nucleotide excision repair II: from yeast to mammals. Trends Genet 9:211-217 (1993).
61. IIH) basic transcription factor. Science 260:58-63 (1993).
62. Mansbridge JN, Hanawalt PC. Domain-limited repair of DNA in ultraviolet irradiated fibroblasts from xeroderma pigmentosum complementation group C. In:Cellular Responses to DNA Damage (Friedberg EC, Bridges BA, eds). New York:Alan R Liss Inc, 1983;195-207.
63. Kantor GJ, Elking CF. Biological significance of domain-oriented DNA repair in xeroderma pigmentosum cells. Cancer Res 48:844-849 (1988).
64. Kantor GJ, Barsalou LS, Hanawalt PC. Selective repair of specific chromatin domains in UV-irradiated cells from xeroderma pigmentosum complementation group C. Mutat Res 235:171-180 (1990).
65. Venema J, van Hoffen A, Karcagi V, Natarajan AT, van Zeeland AA, Mullenders LHS. Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes. Mol Cell Biol 11:4128-4134 (1991).
66. Scicchitano DA, Hanawalt PC. Lack of sequence-specific removal of N-methylpurines from cellular DNA. Mutat Res 233:31-37 (1990).
67. Engelward B, Dreslin A, Christensen J, Huszar D, Kurahara C, Samson L. Repair deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation induced chromosome damage and cell killing. Eur Mol Biol Organ J 15:945-952 (1996).
68. Modrich P. Mechanisms and biological effects of mismatch repair. Annu Rev Genet 25:229-253 (1991).
69. Kolodner RD. Mismatch repair: mechanisms and relationships to cancer susceptibility. Trends Biochem Sci 20:397-401 (1995).
70. Kunkel TA. The intricacies of eukaryotic spell-checking. Curr Biol 5:1091-1094 (1995).
71. Mellon I, Rajpal DK, Koi M, Boland CR, Champe GN. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 272:557-360 (1996).
72. 4-methylthymine, or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci USA 93:6443-6447 (1996).
73. Mello JA, Acharya S, Fishel R, Essigmann JM. The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem Biol 3:579-589 (1996).