Involvement of brain lactate in neuronal metabolism

NMR in Biomedicine

Volumn 16, Issue 6-7, 2003, Pages 430-439

  Serres, Sébastien ^a   Bouyer, Jean Jacques ^b   Bezancon, Eric ^a   Canioni, Paul ^a   Merle, Michel ^a  

^a CNRS University Bordeaux Segalen   (France)

^b INSERM   (France)

Author keywords

13C NMR; Brain energy; Brain metabolism; Cerebral activity; Lactate

Indexed keywords

BLOOD; BRAIN; ELECTRIC CONDUCTIVITY; ELECTROENCEPHALOGRAPHY; GLUCOSE; METABOLISM; NEUROLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

GLYCOLYSIS;

BIOMEDICAL ENGINEERING;

ACETYL COENZYME A; ALANINE; CARBON 13; CHLORALOSE; GLUCOSE; GLUTAMIC ACID; LACTIC ACID; MORPHINE; PENTOBARBITAL; PERCHLORIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CELL METABOLISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROENCEPHALOGRAPHY; ENERGY METABOLISM; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; METABOLIC PARAMETERS; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 0345221682     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.838     Document Type: Article

References (21)

1. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science 1999; 283: 496-497.
2. Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc. Nat. Acad. Sci. USA 1998; 95: 316-321.
3. Chih CP, Lipton P, Roberts EL Jr. Do active cerebral neurons really use lactate rather than glucose? Trends Neurosci. 2001; 24: 573-578.
4. Dienel GA, Hertz L. Glucose and lactate metabolism during brain activation. J. Neurosci. Res. 2001; 66: 824-838.
5. Chih CP, He J, Sly TS, Roberts EL Jr. Comparison of glucose and lactate as substrates during NMDA-induced activation of hippocampal slices. Brain Res. 2001; 893: 143-154.
6. Gjedde A, Marrett S, Vafaee M. Oxidative and non-oxidative metabolism of excited neurons and astrocytes. J. Cereb. Blood. Flow. Metab. 2002; 22: 1-14.
7. 13C]lactate in the rat brain is specific of a pyruvate carboxylase-deprived compartment. J. Neurochem. 2000; 75: 480-486.
8. Hassel B, Brathe A. Cerebral metabolism of lactate in vivo: evidence for neuronal pyruvate carboxylation. J. Cereb. Blood. Flow. Metab. 2000; 20: 327-336.
9. 13C MR spectroscopy study of lactate as substrate for rat brain. Dev. Neurosci. 2000; 22: 429-436.
10. Darnaudéry M, Pallarés M, Bouyer JJ, Le Moal M, Mayo W. Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties. Neuroscience 1999; 92: 583-588.
11. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265-275.
12. 13C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat. J. Neurochem. 1999; 72: 2445-2455.
13. 13C NMR under non-steady state conditions. Biochemistry 1990; 29: 6756-6761.
14. 13C]glucose metabolism. J. Neurochem. 2002; 82: 47-57.
15. 13C NMR. Proc. Nat Acad. Sci. USA 1999; 96: 8235-8240.
16. 13C NMR studies of metabolic compartmentation in the adult mammalian brain. NMR Biomed. 1999; 12: 451-462.
17. Devor M, Zalkind V. Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital. Pain 2001; 94: 101-112.
18. Waagepetersen HS, Sonnewald U, Larsson OM, Shousboe A. A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons. J. Neurochem. 2000; 75: 471-479.
19. 13C]alanine in astrocytes, neurons, and cocultures: implications for glial-neuron interactions in neurotransmitter metabolism. Glia 2000; 32: 286-303.
20. Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Nat. Acad. Sci. USA 1994; 91: 10625-10629.
21. Hu Y, Wilson S. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J. Neurochem. 1997; 69: 1484-1490.