Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci

Molecular Microbiology

Volumn 21, Issue 1, 1996, Pages 33-44

  Arthur, Michel ^a   Depardieu, Florence ^a   Reynolds, Peter ^b   Courvalin, Patrice ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDOGLYCAN; TEICOPLANIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL METABOLISM; CONTROLLED STUDY; ENTEROCOCCUS; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TRANSPOSON;

EID: 0030036676     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.00617.x     Document Type: Article

References (32)

1. Arthur, M., and Courvalin, P. (1993) Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Ag Chemother 37: 1563-1571.
2. Arthur, M., Molinas, C., Mabilat, C., and Courvalin, P. (1990) Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob Ag Chemother 34: 2024-2026.
3. Arthur, M., Molinas, C., and Courvalin, P. (1992a) Sequence of the vanY gene required for production of a vancomycininducible D,D-carboxypeptidase in Enterococcus faecium BM4147. Gene 120: 111-114.
4. Arthur, M., Molinas, C., and Courvalin, P. (1992b) The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol 174: 2582-2591.
5. Arthur, M., Molinas, C., Depardieu, F., and Courvalin, P. (1993) Characterization of Tn 1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM147. J Bacteriol 175: 117-127.
6. Arthur, M., Depardieu, F., Snaith, H.A., Reynolds, P.E., and Courvalin, P. (1994) Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob Ag Chemother 38: 1899-1903.
7. Arthur, M., Depardieu, F., Molinas, C., Reynolds, P., and Courvalin, P. (1995) The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154: 87-92.
8. Billot-Klein, D., Gutmann, L., Sablé, S., Guittet, E., and van Heijenoort, J. (1994) Modification of peptidoglycan precursors is a common feature of the low-level vancomycinresistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum. J Bacteriol 176: 2398-2405.
9. Brisson-Noël, A., Dutka-Malen, S., Molinas, C., Leclercq, R., and Courvalin, P. (1990) Cloning and heterospecific expression of the resistance determinant vanA encoding high-level resistance to glycopeptides in Enterococcus faecium BM4147. Antimicrob Ag Chemother 34: 924-927.
10. Bugg, T.D.H., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P., and Walsh, C.T. (1991) Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30: 10408-10415.
11. Courvalin, P., and Carlier, C. (1986) Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Mol Gen Genet 205: 291-297.
12. Cruz-Rodz, A.L., and Gilmore, M.S. (1990) High efficiency introduction of plasmid DNA into glycine treated Enterococcus faecalis by electroporation. Mol Gen Genet 224: 152-154.
13. Dutka-Malen, S., Molinas, C., Arthur, M., and Courvalin, P. (1990) The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes. Mol Gen Genet 224: 364-372.
14. B two-component regulatory system in Enterococcus faecalis V583. J Bacteriol 178: 1302-1309.
15. Evers, S., Reynolds, P.E., and Courvalin, P. (1994) Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583. Gene 140: 97-102.
16. Gutmann, L., Billot-Klein, D., Al-Obeid, S., Klare, I., Francoual, S., Collatz, E., and van Heijenoort, J. (1992) Inducible carboxypeptidase activity in vancomycin-resistant enterococci. Antimicrob Ag Chemother 36: 77-80.
17. Holman, T.R., Wu, Z., Wanner, B.L., and Walsh, C.T. (1994) Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium. Biochemistry 33: 4625-4631.
18. Jacob, A.E., and Hobbs, S.J. (1974) Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes. J Bacteriol 117: 360-372.
19. Le Bouguénec, C., de Cespédès, G., and Horaud, T. (1990) Presence of chromosomal elements resembling the composite structure Tn3701 in streptococci. J Bacteriol 172: 727-734.
20. Messer, J., and Reynolds, P.E. (1992) Modified peptidoglycan precursors produced by glycopeptide-resistant enterococi. FEMS Microbiol Lett 94: 195-200.
21. Meziane-Cherif, D., Badet-Denisot, M.-A., Evers, S., Courvalin, P., and Badet, B. (1994) Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583. FEBS Lett 354: 140-142.
22. Nicas, T.I., Mullen, D.L., Flokowitsch, J.E., Preston, D.A., Snyder, N.J., Stratford, R.E., and Cooper, R.D.G. (1995) Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other grampositive bacteria. Antimicrob Ag Chemother 39: 2585-2587.
23. Quintiliani, Jr, R., and Courvalin, P. (1994) Conjugal transfer of the vancomycin resistance determinant vanB between enterococci involves the movement of large genetic elements from chromosome to chromosome. FEMS Microbiol Lett 119: 359-364.
24. Quintiliani, Jr, R., Evers, S., and Courvalin, P. (1993) The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci. J lnf Dis 167: 1220-1223.
25. Reynolds, P.E. (1989) Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur J Clin Microbiol Inf Dis 8: 943-950.
26. Reynolds, P.E., Depardieu, F., Dutka-Malen, S., Arthur, M., and Courvalin, P. (1994) Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol Microbiol 13: 1065-1070.
27. Steers, E., Foltz, E.L., Graves, B.S., and Rinden, J. (1959) An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiot Chemother (Basel) 9: 307-311.
28. Trieu-Cuot, P., Carlier, C., Poyart-Salmeron, C., and Courvalin, P. (1991) An integrative vector exploiting the transposition properties of Tn1545 for insertional mutagenesis and cloning of genes from Gram-positive bacteria. Gene 106: 21-27.
29. Williamson, R.C., Al-Obeid, S., Shlaes, J.H., Goldstein, F.W., and Shlaes, D.M. (1989) Inducible resistance to vancomycin in Enterococcus faecium D366. J Inf Dis 159: 1095-1104.
30. Wright, G.D., Molinas, C., Arthur, M., Courvalin, P., and Walsh, C.T. (1992) Characterization of VanY, a D,D-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147. Antimicrob Ag Chemother 36: 1514-1518.
31. Wright, G.D., Holman, T.R., and Walsh, C.T. (1993) Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 32: 5057-5063.
32. Wu, Z., Wright, G.D., and Walsh, C.T. (1995) Overexpression, purification and characterization of VanX, a D,D-dipeptidase which is essential for vancomicin resistance in Enterococcus faecium BM4147. Biochemistry 34: 2455-2463.