Retroviral endostatin gene transfer inhibits growth of human lung cancer in a murine orthotopic xenotransplant model

Langenbeck's Archives of Surgery

Volumn 388, Issue 6, 2003, Pages 401-405

  Kurdow, Roland ^a   Boehle, Arnd S ^a   Ruhnke, Maren ^a   Mendoza, Renata ^a   Boenicke, Lars ^a   Sipos, Bence ^a   Schniewind, Bodo ^a   Dohrmann, Peter ^a   Kalthoff, Holger ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Endostatin; Gene therapy; Lung cancer; Retroviral vector

Indexed keywords

ENDOSTATIN; RETROVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER; METASTASIS; MOUSE; NONHUMAN; PLEURA METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; VIRAL GENE DELIVERY SYSTEM; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; ENDOSTATINS; FEMALE; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOBLOTTING; LUNG NEOPLASMS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0345098500     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-003-0400-8     Document Type: Article

References (25)

1. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136:261-276
2. Folkman J (1995) Seminars in medicine of the Beth Israel Hospital, Boston: clinical applications of research on angiogenesis. N Engl J Med 333:1757-1763
3. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364
4. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-285
5. Kim YM, Hwang S, Kim YM, Pyun BJ, Kim TY, Lee ST, Gho YS, Kwon YG (2002) Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem 277:27872-27879
6. Lee SJ, Jang JW, Kim YM, Lee HI, Jeon JY, Kwon YG, Lee ST (2002) Endostatin binds to the catalytic domain of matrix metalloproteinase-2. FEBS Lett 519:147-152
7. Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S (2002) Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol 158:529-539
8. Chen QR, Kumar D, Stass SA, Mixson AJ (1999) Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res 59:3308-3312
9. Blezinger P, Wang J, Gondo M, Quezada A, Mehrens D, French M, Singhal A, Sullivan S, Rolland A, Ralston R, Min W (1999) Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nat Biotechnol 17:343-348
10. Szary J, Szala S (2001) Intra-tumoral administration of naked plasmid DNA encoding mouse endostatin inhibits renal carcinoma growth. Int J Cancer 91:835-839
11. Ding I, Sun JZ, Fenton B, Liu WM, Kimsely P, Okunieff P, Min W (2001) Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas. Cancer Res 61:526-531
12. Yoon SS, Eto H, Lin CM, Nakamura H, Pawlik TM, Song SU, Tanabe KK (1999) Mouse endostatin inhibits the formation of lung and liver metastases. Cancer Res 59:6251-6256
13. Wen XY, Bai Y, Stewart AK (2001) Adenovirus-mediated human endostatin gene delivery demonstrates strain-specific antitumor activity and acute dose-dependent toxicity in mice. Hum Gene Ther 12:347-358
14. Regulier E, Paul S, Marigliano M, Kintz J, Poitevin Y, Ledoux C, Roecklin D, Cauet G, Calenda V, Homann HE (2001) Adenovirus-mediated delivery of antiangiogenic genes as an antitumor approach. Cancer Gene Ther 8:45-54
15. Nguyen JT, Wu P, Clouse ME, Hlatky L, Terwilliger EF (1998) Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy. Cancer Res 58:5673-5677
16. Feldman AL, Restifo NP, Alexander HR, Bartlett DL, Hwu P, Seth P, Libutti SK (2000) Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice. Cancer Res 60:1503-1506
17. Indraccolo S, Gola E, Rosato A, Minuzzo S, Habeler W, Tisato V, Roni V, Esposito G, Morini M, Albini A, Noonan DM, Ferrantini M, Amadori A, Chieco-Bianchi L (2002) Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells. Gene Ther 9:867-878
18. Boehle AS, Dohrmann P, Leuschner I, Kalthoff H, Henne-Bruns D (2000) An improved orthotopic xenotransplant procedure for human lung cancer in SCID bg mice. Ann Thorac Surg 69:1010-1015
19. Finer MH, Dull TJ, Qin L, Farson D, Roberts MR (1994) kat: a high-efficiency retroviral transduction system for primary human T lymphocytes. Blood 83:43-50
20. Boehle AS, Kurdow R, Schulze M, Kliche U, Sipos B, Soondrum K, Ebrahimnejad A, Dohrmann P, Kalthoff H, Henne-Bruns D, Neumaier M (2001) Human endostatin inhibits growth of human non-small-cell lung cancer in a murine xenotransplant model. Int J Cancer 94:420-428
21. Tomayko MM, Reynolds CP (1989) Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24:148-154
22. Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N Engl J Med 324:1-8
23. Vermeulen PB, Gasparini G, Fox SB, Toi M, Martin L, McCulloch P, Pezzella F, Viale G, Weidner N, Harris AL, Dirix LY (1996) Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 32A:2474-2484
24. Folkman J (1998) Antiangiogenic gene therapy. Proc Natl Acad Sci USA 95:9064-9066
25. Lefesvre P, Attema J, van Bekkum D (2002) Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth. BMC Cancer 2:17