Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 241-247

  Fraser, David J ^a   He, You Qun ^a   Harlow, Greg R ^a,b   Halpert, James R ^a,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b Selectide Corporation   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OXYGENASE; PROGESTERONE;

ARTICLE; CHIMERA; CODON; DOG; ENZYME ACTIVITY; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEROID HYDROXYLATION;

EID: 0344938176     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.241     Document Type: Article

References (23)

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