Decreased Expression of Vascular Endothelial Growth Factor in Idiopathic Membranous Glomerulonephritis: Relationships to Clinical Course

American Journal of Kidney Diseases

Volumn 42, Issue 6, 2003, Pages 1139-1148

  Honkanen, Eero ^a   Von Willebrand, Eva ^b   Koskinen, Petri ^b   Teppo, Anna Maija ^b   Törnroth, Tom ^b   Ruutu, Mirja ^b   Grönhagen Riska, Carola ^b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NONE

Author keywords

Growth factors; Membranous glomerulonephritis (MGN); Podocytes; Prognosis; Proteinuria; Vascular endothelial growth factor (VEGF)

Indexed keywords

MESSENGER RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ADULT; AGED; ARTICLE; ASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEMBRANOUS GLOMERULONEPHRITIS; NEPHRECTOMY; PODOCYTE; PRESCHOOL CHILD; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; URINARY EXCRETION;

EID: 0344827156     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2003.08.014     Document Type: Article

References (29)

1. Cattran DC: Idiopathic membranous glomerulonephritis. Kidney Int 59:1983-1994, 2001
2. Farquhar MG, Saito A, Kerjaschki D, Orlando RA: The Heymann nephritis antigenic complex: Megalin (gp330) and RAP. J Am Soc Nephrol 6:35-47, 1995
3. Couser WG: Pathogenesis of glomerular damage in glomerulonephritis. Nephrol Dial Transplant 13:S10-S15, 1998 (suppl 1)
4. Ferrara N: Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56:794-814, 1999
5. Ferrara N, Bunting S: Vascular endothelial growth factor, a specific regulator of angiogenesis. Curr Opin Nephrol Hypertens 5:35-44, 1996
6. Remuzzi G, Benigni A: Repairing renal lesions: Will VEGF be the builder? Kidney Int 58:2594-2595, 2000
7. Clauss M: Molecular biology of the VEGF and the VEGF receptor family. Semin Thromb Hemost 26:561-569, 2000
8. Brown LF, Berse B, Tognazzi K, et al: Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int 42:1457-1461, 1992
9. Kretzler M, Schroppel B, Merkle M, et al: Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes. Kidney Int Suppl 67:S159-S161, 1998
10. Simon M, Rockl W, Hornig C, et al: Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: Localization and (1251)VEGF binding sites. J Am Soc Nephrol 9:1032-1044, 1998
11. Thomas S, Vanuystel J, Gruden G, et al: Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease. J Am Soc Nephrol 11:1236-1243, 2000
12. Kanellis J, Fraser S, Katerelos M, Power DA: Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells. Am J Physiol Ren Physiol 278:F905-F915, 2000
13. Lemström KB, Krebs R, Nykänen AI, et al: Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis. Circulation 105:2524-2530, 2002
14. Honkanen EO, Teppo A-M, Grönhagen-Riska C: Decreased urinary excretion of vascular endothelial growth factor in idiopathic membranous glomerulonephritis. Kidney Int 57:2343-2349, 2000
15. Honkanen E, Törnroth T, Grönhagen-Riska C, Sankila R: Long term survival in idiopathic membranous glomerulonephritis: Can the course be clinically predicted? Clin Nephrol 41:127-134, 1994
16. Hornig C, Weich HA: Soluble VEGF receptors. Angiogenesis 3:33-39, 1999
17. Schwartz MM: Membranous glomerulonephritis, in Jennette JC, Olson JE, Schwartz MM, Silva FG (eds): Heptinstall's Pathology of the Kidney. Philadelphia, PA, Lippincott-Raven, 1998, pp 309-368
18. Schulman K, Rosen S, Tognazzi K, et al: Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases. J Am Soc Nephrol 7:661-666, 1996
19. Bailey E, Bottomley MJ, Westwell S, et al: Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by non-isotopic in situ hybridization. J Clin Pathol 52:735-738, 1999
20. Sivridis E, Giatromanolaki A, Touloupidis S, Pasadakis P, Vergemezis V: Platelet endothelial cell adhesion molecule-1 and angiogenic factor expression in idiopathic membranous nephropathy. Am J Kidney Dis 41:360-365, 2003
21. McMillan JI, Riordan JW. Couser WG, et al: Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. J Clin Invest 97:1094-1101, 1996
22. Eremina V, Sood MM, Haigh J, et al: Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 111:707-716, 2003
23. Satchell SC, Harper SJ, Tooke JE, et al: Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor. J Am Soc Nephrol 13:544-550, 2002
24. Shahbazi M, Fryer AA, Pravica V, et al: Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 13:260-264, 2002
25. Masuda Y, Shimizu A, Mori T, et al: Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 159:599-608, 2001
26. Wada Y, Morioka T, Oyanagi-Tanaka Y, et al: Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis. Kidney Int 61:432-443, 2002
27. 165 mediates glomerular endothelial repair. J Clin Invest 104:913-923, 1999
28. Fan L, Wakayama T, Yokoyama S, et al: Downregulation of vascular endothelial growth factor and its receptors in the kidney in rats with puromycin aminonucleoside nephrosis. Nephron 90:95-102, 2002
29. Kim Y-G, Suga S-I, Kang D-H, et al: Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy. Kidney Int 58:2390-2399, 2000