Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: Localization and [125I]VEGF binding sites

Journal of the American Society of Nephrology

Volumn 9, Issue 6, 1998, Pages 1032-1044

  Simon, Matthias ^a,e   Röckl, Wolfgang ^b   Hornig, Carsten ^b   Gröne, Elisabeth F ^a   Theis, Henner ^a   Weich, Herbert A ^b   Fuchs, Eberhard ^c   Yayon, Avner ^d   Gröne, Hermann Josef ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c GERMAN PRIMATE CENTER   (Germany)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; GROWTH FACTOR; IODINE 125; PLASMINOGEN ACTIVATOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ADULT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DENSITOMETRY; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR BINDING;

EID: 0345164367     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Schwartz MM, Venkatachalam MA: Ultrastructural differences between rat inner medullary descending and ascending vasa recta. Lab Invest 35: 161-170, 1976
2. Brenner BM, Deen WM, Robertson CR: Glomerular filtration. In: The Kidney, edited by Brenner BM, Rector FC Jr, Philadelphia, W. B. Saunders, 1976, pp 251-271
3. Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114: 521-532, 1992
4. Peters KG, De Vries C, Williams LT: Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90: 8915-8919, 1993
5. Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-858, 1989
6. Senger DR: Molecular framework for angiogenesis: A complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol 149: 1-7, 1996
7. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439, 1996
8. Ferrare N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442, 1996
9. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW: The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814, 1991
10. Park JE, Keller GA, Ferrara N: The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 4: 1317-1326, 1993
11. Brown LF, Berse B, Tognazzi K, Manseau EJ, Van de Water L, Senger DP, Dvorak HF, Rosen S: Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int 42: 1457-1461, 1992
12. Simon M, Gröne HJ, Jöhren O, Kullmer J, Plate KH, Fuchs E, Risau W: Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol 268: F240-F250, 1995
13. Kloth S, Ebenbeck C, Kubitza M, Schmidbauer A, Röckl W, Minuth WW: Stimulation of renal microvascular development under organotypic culture conditions. FASEB J 9: 963-967, 1995
14. Kitamoto Y, Tokunaga H, Tomita K: Vascular endothelial growth factor is an essential molecule for mouse kidney development: Glomerulogenesis and nephrogenesis. J Clin Invest 99: 2351-2357, 1997
15. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familetti PC, Pan YCE, Olander JV, Connolly DT, Stern D: Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity and promotes migration. J Exp Med 172: 1535-1545, 1990
16. Unemori EN, Ferrara N, Bauer EA, Amento EP: Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153: 557-562, 1992
17. Pepper MS, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181: 902-906, 1991
18. Mandriota SJ, Seghezzi G, Vassalli JD, Ferrara N, Wasi S, Mazzieri R, Mignatti P, Pepper MS: Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 270: 9709-9716, 1995
19. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991, 1992
20. Millhauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Moller NPH, Risau W, Ullrich A: High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-846, 1993
21. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitmann ML, Schuh AC: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66, 1995
22. Fong GH, Rossant J, Gertsenstein M, Breitman ML: Role of the Fit-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995
23. Oberg C, Waltenberger J, Claesson WL, Welsh M: Expression of protein tyrosine kinases in islet cells: Possible role of the Flk-1 receptor for beta cell maturation from duct cells. Growth Factors 10: 115-126, 1994
24. Takahashi T, Shirasawa T, Miyake K, Yahagi I, Maruyama N, Kasahara N, Kawamira T, Matsumura O, Mitarai T, Sakai O: Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Fit-1 and VEGF expression in renal mesangial cells. Biochem Biophys Res Commun 209: 218-226, 1995
25. Brown LF, Detmar M, Tognazi K, Abu-Jawdek G, Iruela-Arispe ML: Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor/vascular endothelial growth factor. Lab Invest 76: 245-255, 1997
26. 121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem 270: 11322-11326, 1995
27. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N: Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89: 244-253, 1992
28. 125I] endothelin binding sites in mammalian kidneys. Comp Biochem Physiol 101A: 775-778, 1992
29. Gröne HJ, Simon M, Fuchs E: Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney. Am J Physiol 262: F326-F331, 1992
30. Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG: Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PLGF), are transcribed from a single gene of chromosome 14. Oncogene 4: 925-931, 1993
31. Hauser S, Weich HA: A heparin-binding form of placenta growth factor (PLGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 9: 259-268, 1993
32. Terman B, Khandke L, Dougher-Vermazan M, Maglione D, Lassam NJ, Gospodarowicz D, Persico MG, Böhlen P, Eisinger M: VEGF receptor subtypes KDR and Flt-1 show different sensitivities to heparin and placenta growth factor. Growth Factors 11: 187-195, 1994
33. Clauss M, Weich H, Breier G, Knies U, Röckl W, Waltenberger J, Risau W: The vascular endothelial growth factor receptor flt-1 mediates biological activities: Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 271: 17629-17634, 1996
34. Barleon B, Totzke F, Herzog C, Blanke S, Kremmer E, Siemeister G, Marme D, Martiny-Baron G: Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor Fit-1. J Biol Chem 272: 10382-10388, 1997
35. Waltenberger J, Claesson WL, Siegbalm A, Shibuya M, Heldin C-H: Different signal transduction properties of KDR and tit-1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-26995, 1994
36. Fiebich BL, Jäger B, Schöllmann C, Weindel K, Wilting J, Kochs G, Marme D, Hug H, Weich HA: Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells. Eur J Biochem 211: 19-26, 1993
37. 125I] standards for quantitative receptor autoradiography. J Neurosci Methods 5: 75-82, 1988
38. Ferrara N, Houck K, Jakeman L, Leung DW: Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13: 18-32, 1992
39. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J: Tumor vascular permeability factor stimulates endothelial growth and angiogenesis. J Clin Invest 84: 1470-1478, 1989
40. Dvorak HF, Brown LF, Detmar M, Dvorak AM: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039, 1995
41. Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxea A, Clark WC, Robertson JT, Ali IU, Oldfield EH: Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91: 153-159, 1993
42. Alello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487, 1994
43. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N: Vascular endothelial growth factor: A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 152: 4149-4156, 1994
44. Kaipainen A, Korhonen J, Pajusola K, Aprelikova O, Persico MG, Terman BI, Alitalo K: The related flt 4, flt 1 and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells. J Exp Med 178: 2077-2088, 1993
45. Gröne HJ, Simon M, Gröne EF: Expression of vascular endothelial growth factor in renal vascular disease and allografts. J Pathol 177: 259-267, 1995
46. Robert B, St. John PL, Hyink DP, Abrahamson DR: Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts. Am J Physiol 271: F744-F753, 1996
47. Cullianan-Bove K, Koos RD: Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology 133: 829-837, 1993
48. Klanke B, Simon M, Röckl W, Weich HA, Stolte H, Gröne HJ: Effects of vascular endothelial growth factor (VEGF) vascular permeability factor (VPF) on hemodynamics and permselectivity of the isolated perfused rat kidney. Nephrol Dial Transplant 13: 875-885, 1998
49. Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D: Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 3: 3336-3343, 1997
50. Roberts WG, Palade GE: Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108: 2369-2379, 1995