Description of a putative type I secretion system in Legionella pneumophila

International Journal of Medical Microbiology

Volumn 293, Issue 5, 2003, Pages 349-358

  Jacobi, Sebastian ^a   Heuner, Klaus ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

ABC transporter; HlyBD; Legionella; Type I secretion

Indexed keywords

ABC TRANSPORTER; BACTERIAL PROTEIN; PROTEIN LSSB; PROTEIN LSSD; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; COMPUTER ANALYSIS; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; LEGIONELLA PNEUMOPHILA; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA TYPHI; VIBRIO CHOLERAE;

EID: 0344739973     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00276     Document Type: Article

References (31)

1. Andrews, H. L., Vogel, J. P., Isberg, R. R.: Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect. Immun. 66, 950-958 (1998).
2. Aragon, V., Kurtz, S., Flieger, A., Neumeister, B., Cianciotto, N. P.: Secreted enzymatic activities of wild-type and pilD-deficient Legionella pneumophila. Infect. Immun. 68, 1855-1863 (2000).
3. Binet, R., Letoffe, S., Ghigo, J. M., Delepelaire, P., Wandersman, C.: Protein secretion by Gram-negative bacterial ABC exporters. Gene 192, 7-11 (1997).
4. China, B., Goffaux, F.: Secretion of virulence factors by Escherichia coli. Vet. Res. 30, 181-202 (1999).
5. Cirillo, S. L., Lum, J., Cirillo, J. D.: Identification of novel loci involved in entry by Legionella pneumophila. Microbiology 146, 1345-1359 (2000).
6. Cirillo, S. L., Bermudez, L. E., El-Etr, S. H., Duhamel, G. E., Cirillo, J. D.: Legionella pneumophila entry gene rtxA is involved in virulence. Infect. Immun. 69, 508-517 (2001).
7. Cirillo, S. L., Yan, L., Littman, M., Samrakandi, M. M., Cirillo, J. D.: Role of the Legionella pneumophila rtxA gene in amoebae. Microbiology 148, 1667-1677 (2002).
8. Edelstein, P. H., Edelstein, M. A., Higa, F., Falkow, S.: Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model. Proc. Natl. Acad. Sci. USA 6, 8190-8195 (1999).
9. Fields, B. S., Barbaree, J. M., Sanden, G. N., Morrill, W. E.: Virulence of a Legionella anisa strain associated with Pontiac fever: an evaluation using protozoan, cell culture, and guinea pig models. Infect. Immun. 58, 3139-3142 (1990).
10. Fields, B. S.: The molecular ecology of legionellae. Trends Microbiol. 4, 286-290 (1996).
11. Gal-Mor, O., Zusman, T., Segal, G.: Analysis of DNA regulatory elements required for expression of Legionella pneumophila icm and dot virulence genes. Infect. Immun. 184, 3823-3833 (2002).
12. Hales, L. M., Shuman, H. A.: Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease. Infect. Immun. 67, 3662-3666 (1999).
13. Heuner, K., Bender-Beck, L., Brand, B. C., Lück, P. C., Mann, K-H., Marre, R., Ott, M., Hacker, J.: Cloning and genetic characterization of the flagellum subunit gene (flaA) of Legionella pneumophila serogroup 1. Infect. Immun. 63, 2499-2507 (1995).
14. Heuner, K., Dietrich, C., Steinert, M., Göbel, U. B., Hacker, J.: Cloning and characterization of a Legionella pneumophila specific gene encoding a member of the LysR family of transcriptional regulators. Mol. Gen. Genet. 264, 204-211 (2000).
15. Highlander, S. K., Engler, M. J., Weinstock, G. M.: Secretion and expression of the Pasteurella haemolytica leukotoxin. J. Bacteriol. 172, 2343-2350 (1990).
16. Jepras, R. I., Fitzgeorge, R. B., Baskerville, A.: A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs. J. Hyg. 95, 29-38 (1985).
17. Lee, V. T., Schneewind, O.: Protein secretion and the pathogenesis of bacterial infections. Genes Dev. 15, 1725-1752 (2001).
18. Liles, M. R., Viswanathan, V. K., Cianciotto, N. P.: Identification and temperature regulation of Legionella pneumophila genes involved in type IV pilus biogenesis and type II protein secretion. Infect. Immun. 66, 1776-1782 (1998).
19. Liles, M. R., Edelstein, P. H., Cianciotto, N. P.: The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila. Mol. Microbiol. 31, 959-970 (1999).
20. Lin, W., Fullner, K. J., Clayton, R., Sexton, J. A., Rogers, M. B., Calia, K. E., Calderwood, S. B., Fraser, C., Mekalanos, J. J.: Identification of a Vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc. Natl. Acad. Sci. USA 96, 1071-1076 (1999).
21. Pearson, W. R., Lipman, D. J.: Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85, 2444-2448 (1988).
22. Polesky, A. H., Ross, J. T., Falkow, S., Tompkins, L. S.: Identification of Legionella pneumophila genes important for infection of amoebas by signature-tagged mutagenesis. Infect. Immun. 69, 977-987 (2001).
23. Ponting, C. P., Aravind, L.: PAS: a multifunctional domain family comes to light. Curr. Biol. 7, R674-R677 (1997).
24. Reed, K. E., Cronan, J. E. Jr.: Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. J. Bacteriol. 175, 1325-1336 (1993).
25. Rossier, O., Cianciotto, N. P.: Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila. Infect. Immun. 69, 2092-2098 (2001).
26. Sambrook, J., Fritsch, E. F., Maniatis, T.: Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. 1989.
27. Segal, G., Shuman, H. A.: Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect. Immun. 67, 2117-2124 (1999).
28. Segal, G., Russo, J. J., Shuman, H. A.: Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila. Mol. Microbiol. 34, 799-809 (1999).
29. Stanley, P., Koronakis, V., Hughes, C.: Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function. Microbiol. Mol. Biol. Rev. 62, 309-333 (1998).
30. Wandersman, C., Delepelaire, P.: TolC, an Escherichia coli outer membrane protein required for hemolysin secretion. Proc. Natl. Acad. Sci. USA 87, 4776-4780 (1990).
31. Zhulin, I. B., Taylor, B. L., Dixon, R.: PAS domain S-boxes in archaea, bacteria and sensors for oxygen and redox. Trends Biochem. Sci. 22, 331-333 (1997).