Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis

Bioprocess and Biosystems Engineering

Volumn 26, Issue 1, 2003, Pages 1-10

  Frahm, B ^a   Lane, P ^b   Markl H ^a   Portner R ^a  

^a HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

^b Inst fur Technol Biosystemtechnik   (Germany)

Author keywords

Apoptosis bcl 2 overexpression; Fed batch; NS0 cells; Process control

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PROTEIN BCL 2; RECOMBINANT PROTEIN;

ADAPTATION; ALGORITHM; ANIMAL; ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; BIOREACTOR; BIOSYNTHESIS; CELL CULTURE; CELL DENSITY; CELL DIVISION; CELL GROWTH; CELL LINE; CELL SURVIVAL; COMPARATIVE STUDY; COMPUTER SIMULATION; DIALYSIS; FED BATCH CULTURE; FEEDBACK SYSTEM; GENETIC ENGINEERING; GENETICS; HUMAN; IMMUNOLOGY; METHODOLOGY; MOUSE; MULTIPLE MYELOMA; NONHUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROCESS CONTROL; PROCESS MODEL; PROTEIN ENGINEERING; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ADAPTATION, PHYSIOLOGICAL; ALGORITHMS; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; COMPUTER SIMULATION; DIALYSIS; FEEDBACK; HUMANS; IMMUNOGLOBULIN G; MICE; MODELS, BIOLOGICAL; MULTIPLE MYELOMA; PROTEIN ENGINEERING; PROTO-ONCOGENE PROTEINS C-BCL-2; QUALITY CONTROL; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

ANIMALIA; MAMMALIA;

EID: 0344736650     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-003-0335-z     Document Type: Article

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