The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

Pharmaceutical Biology

Volumn 41, Issue 6, 2003, Pages 449-453

  Martínez, Elizdath ^a   García, Alberto ^a   Saenz, Angel ^a   Garduño, Leticia ^a   Salazar, María ^a   Chamorro, Germán ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Diabetes; Embryotoxicity; Glycation; Glycine; Teratogenesis

Indexed keywords

GLYCINE; HEMOGLOBIN A1C; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL MALFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DRUG EFFECT; EMBRYO; EMBRYOTOXICITY; FEMALE; FETUS; FETUS MALFORMATION; FLUID INTAKE; GESTATION PERIOD; GLYCATION; MOUSE; NONHUMAN; PREGNANCY; TERATOGENICITY;

ANIMALIA;

EID: 0344553336     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.41.6.449.17824     Document Type: Article

References (28)

1. Brownlee M, Vlassara H, Cerami A (1984): Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 101: 527-537.
2. Carvajal G, Juarez E, Ramos G, Carvajal ME, Medina-Santillan R (1999a): Inhibition of hemoglobin glycation with glycine in induced diabetes mellitus in rats. Proc West Pharmacol Soc 42: 35-36.
3. Carvajal G, Medina R, Juarez E, Ramos G, Carvajal ME (1999b): Effect of glycine on hemoglobin glycation in diabetic patients. Proc West Pharmacol Soc 42: 31-32.
4. Carvajal-Sandoval G, Juárez de Carvajal E, Ramos-Martínez G, Carvajal-Juárez ME (1995): Inhibición de la glicosilación no enzimática de la hemoglobina en la diabetes mellitus. Rev Inst Nac Enf Resp Méx 8: 185-188.
5. Engström E, Haglund A, Eriksson UJ (1991): Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos. Pediatr Res. 30: 150-153.
6. Eriksson U, Dahlström E, Larsson KS, Hellerström C (1982): Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy. Diabetes 31: 1-6.
7. Eriksson UJ, Borg LAH (1991): Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro. Diabetologia 34: 325-331.
8. Eriksson UJ, Karlsson M, Styrud J (1987): Mechanisms of congenital malformations in diabetic pregnancy. Biol Neonate 51: 113-118.
9. Fein A, Magid N, Savion N, Orenstein H, Shepshelovich J, Ornoy A, Torchinsky A, Toder V (2002): Diabetes teratogenicity in mice is accompanied with distorted expression of TGF-β2 in the uterus. Teratogenesis Carcinog Mutagen 22: 59-71.
10. Greenstein JP, Winitz M (1961): Glycine. Chemistry of the Amino Acids. New York-London, John Wiley & Sons, Inc.
11. Khandelwal M, Reece EA, Wu KY, Borenstein M (1998): Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. Teratology 57: 79-84.
12. Kubow S, Yaylayan V, Mandeville S (1993): Protection by acetylsalicylic acid against hyperglycemia-induced glycation and neural tube defects in cultured early somite mouse embryos. Diabetes Res 22: 145-158.
13. Lee AT, Plump A, DeSimone C, Cerami A, Bucala R (1995): A role for DNA mutations in diabetes-associated teratogenesis in transgenic embryos. Diabetes 44: 20-24.
14. Lee AT, Reis D, Eriksson UJ (1999): Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo. Diabetes 48: 371-376.
15. Miodovnik M, Mimouni F, Siddiqi TA, Khoury J, Berk MA (1990): Spontaneous abortions in repeat diabetic pregnancies: A relationship with glycemic control. Obstet Gynecol 75: 75-78.
16. Peters PW (1977): Double staining of fetal skeletons for cartilage and bone. In: Neubert D, Merker HJ, and Kwasigroch TE, eds., Methods in Prenatal Toxicology. Stuttgart, Georg Thieme Publ.
17. Pollak A, Salzer HR, Lischka A, Hayde M (1988): Non-enzymatic glycation of fetal tissue in diabetic pregnancy: Estimation of the glucitollysine content of umbilical cord extracts. Acta Pædiatr Scand 77: 481-484.
18. Ramakrishnan S, Sulochana KN (1993): Decrease in glycation of lens proteins by lysine and glycine by scavenging of glucose and possible mitigation of cataractogenesis. Exp Eye Res 57: 623-628. (Abstract).
19. Reece EA, Homko CJ, Wu YK (1996): Multifactorial basis of the syndrome of diabetic embryopathy. Teratology 54: 171-182.
20. Rosenn B, Miodovnik M, Combs A, Khoury J, Siddiqi TA (1994): Glycemic thresholds for spontaneous abortion and congenital malformations in insulin-dependent diabetes mellitus. Obstet Gynecol 84: 515-520.
21. Schleicher E, Wieland OH (1989): Protein glycation: Measurement and clinical relevance. J Clin Chem Clin Biochem 27: 577-587.
22. Suhonen L, Hiilesmaa V, Teramo K (2000): Glycaemic control during early pregnancy and fetal malformations in women with Type I diabetes mellitus. Diabetologia 43: 79-82.
23. Torchinsky A, Toder V, Carp H, Orenstein H, Fein A (1997a): In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: Relevance to the etiology of diabetic teratogenesis. Early Preg Biol Med 3: 27-33.
24. Torchinsky A, Toder V, Savion J, Shepshelovich J, Orenstein H, Fein A (1997b): Immunostimulation increases the resistance of mouse embryos to the teratogenic effect of diabetes mellitus. Diabetologia 40: 635-640.
25. Uriu-Hare JY, Stern JS, Keen CL (1989): Influence of maternal dietary Zn intake on expression of diabetes-induced teratogenicity in rats. Diabetes 38: 1282-1290.
26. Wentzel P, Eriksson UJ (1998): Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro. Diabetes 47: 677-684.
27. Wilson JG (1965a): Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG and Warkany J, eds. Teratology: Principles and Techniques. Chicago, Univ Chicago Press.
28. Wilson JG (1965b): Embryological considerations in teratology. In: Wilson JG and Warkany J, eds., Teratology: Principles and Techniques. Chicago, Univ Chicago Press.