Immunostimulation increases the resistance of mouse embryos to the teratogenic effect of diabetes mellitus

Diabetologia

Volumn 40, Issue 6, 1997, Pages 635-640

  Torchinsky, A ^a   Toder, V ^a   Savion, S ^a   Shepshelovich, J ^a   Orenstein, H ^a   Fein, A ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Diabetes mellitus; Immune system; Immunostimulation; Inborn anomalies; Teratogenesis

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DIABETES MELLITUS; EMBRYO DEVELOPMENT; FEMALE; FETUS MALFORMATION; IMMUNOSTIMULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; TERATOGENESIS;

ABNORMALITIES; ADJUVANTS, IMMUNOLOGIC; ANIMALS; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FETAL RESORPTION; FETUS; IMMUNOPHENOTYPING; LYMPHOCYTE TRANSFUSION; LYMPHOCYTES; MALE; MICE; MICE, INBRED ICR; PREGNANCY; PREGNANCY IN DIABETICS; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; SPLEEN; TERATOGENS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030811090     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050727     Document Type: Article

References (30)

1. 1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology 39: 225-231
2. Reece EA, Homko CJ, Wu YK (1996) Multifactorial basis of the syndrome of diabetic embryopathy. Teratology 54: 171-183
3. Sadler TW, Hunter III ES, Wynn RE, Phillips LS (1989) Evidence for multifactorial origin of diabetes-induced embryopathies. Diabetes 38: 70-74
4. Toder V, Carp H, Strassburger D (1994) Maternal immune recognition of pregnancy. J Israel Med Sci 30: 787-792
5. Hunt JS (1992) Immunobiology of pregnancy. Curr Opin Immunol 4: 591-596
6. Rabinovitch A (1995) Perspectives in diabetes. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43: 613-621
7. Hoet JJ, Reusenc-Billen B, Catalano M (1992) Immunological aspects of diabetic pregnancies. In: Coulam CB, Faulk WP, McIntyre WW (eds) Immunological obstetrics. Norton, New York, London, pp 518-528
8. Pampfer S, Yanderheyden I, Wuu Y-D, Baufays L, Maillet O, De Hertogh R (1995) Possible role of THF- in early embryopathy associated with maternal diabetes in the rat. 44: 531-536
9. Toder V, Torchinsky A (1996) Immunoteratology: where we are and where to go. Am J Rep Immunol 35: 114-117
10. Torchinsky A, Fein A, Carp HJA, Toder V (1994) MHC-associated immunopotentiation affects the embryo response to teratogens. Clin Exp Immunol 98: 513-519
11. Torchinsky A, Fein A, Toder V (1995) Immunoteratology: I. MHC involvement in the embryo response to teratogens in mice. Am J Reprod Immunol 34: 288-298
12. Beebe LFS, Kaye PL (1990) Preimplantation development in the streptozotocin-induced diabetic mouse. Reprod Fertil Dev 4: 407-412
13. Torchinsky A, Fein A, Toder V (1995) Modulation of embryo sensitivity to teratogen by nonspecific intrauterine immunopotentiation. Toxicol Methods 5: 131-141
14. Zusman I, Ornoy A (1990) Embryonic resistance to chemical and physical factors: manifestation, mechanisms, role in reproduction and adaptation to ecology. Biol Rev 65: 1-18
15. Torchinsky A, Toder V, Carp H, Orenstein H, Fein A (1997) In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: relevance to the etiology of diabetic teratogenesis. Early Pregnancy: biology and medicine. 2: 1-7
16. Wilson DH, Bogacz JP, Forsythe CM, Turk PJ, Lane TL, Gates RC, Brandt DR (1993) Fully automated assay of glycohaemoglobin with the IMx analyzer: novel approaches for separation and detection. Clin Chem 39: 2090-2097
17. Wilson JG (1965) Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, Warkany J (eds) Teratology: priniciples and techniques. University of Chicago Press, Chicago, pp 267-277
18. Savion S, Toder V (1995) Pregnancy-associated effect on mouse thymocytes in vitro. Cellular Immunol 162: 282-287
19. Fraser FC (1977) The multifactorial/threshold concept-uses and misuses. Teratology 14: 267-280
20. Hunt JS (1994) Immunologically relevant cells in the uterus. Biol Reprod 50: 461-466
21. Schwartzman RA, Gidlowski JA (1993) Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrine Reviews 14: 133-151
22. Vercheval M, De Hertogh R, Pampfer S et al. (1990) Experimental diabetes impairs rat embryo development during the preimplantation period. Diabetologia 33: 187-191
23. Beebe LFS, Kaye PL (1991) Maternal diabetes and retarded preimplantation development in mice. Diabetes 40: 457-461
24. Pamper S, Wuu YD, Vanderheyden I, De Hertogh R (1994) In vitro study of the carry-over effect associated with early diabetic embryopathy. Diabetologia 37: 855-862
25. Kalter H (1996) Reproductive toxicology in animals with induced and spontaneous diabetes. Reprod Toxicol 10: 417-438
26. Torchinsky A, Savion S, Gorivodsky M et al. (1995) Cyclophosphamide-induced teratogenesis in ICR mice: the role of apoptosis. Teratogen Carcinog Mutagen 15: 179-190
27. Toder V, Savion S, Gorivodsky M et al. (1996) Teratogen-induced apoptosis may be affected by immunopotentiation. J Rep Immunol 30: 173-185
28. Hill AL, Cai J, Phelan SA, Loeken MR (1996) Identification of a cell cycle-regulated gene whose abnormal expression in embryos of diabetic mice is associated with neural tube defects. Diabetes 45 [Suppl 2]:57 (Abstract)
29. Bursh W, Oberhammer F, Shulte-Hermann R (1992) Cell death by apoptosis and its protective role against disease. TIPS 13: 245-251
30. Harrington EA, Fanidi A, Evan GI (1994) Oncogenes and cell death. Curr Opin Genet Dev 4: 120-129