Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors

European Journal of Pharmacology

Volumn 314, Issue 3, 1996, Pages 385-392

  Kostenis, Evi ^b   Botero Cid, Hector M ^a   Holzgrabe, Ulrike ^a   Mohr, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Allosteric modulation; Heart porcine; Muscarinic receptor; Structure activity relationship

Indexed keywords

BIS(PYRIDINIUM OXIME) DERIVATIVE; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; OXIME DERIVATIVE; TRIMEDOXIME;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; HEART MUSCLE FIBER MEMBRANE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SWINE;

ALLOSTERIC REGULATION; BENZYL COMPOUNDS; METHYLATION; PHTHALIMIDES; PYRIDINIUM COMPOUNDS; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; STATISTICS, NONPARAMETRIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0000246198     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00568-7     Document Type: Article

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