Synthesis of diblock copolymer, methoxypoly(ethylene glycol)-block-polyamidoamine dendrimer and its generation-dependent self-assembly with plasmid DNA

Bulletin of the Korean Chemical Society

Volumn 24, Issue 1, 2003, Pages 123-125

  Kim, Tae Il ^a   Jang, Hyung Suk ^a   Joo, Dong Kyoon ^a   Choi, Joon Sig ^a   Park, Jong Sang ^a  

^a Seoul National University   (South Korea)

Author keywords

Block copolymer; Poly(amidoamine) dendrimer; Poly(ethylene glycol); Polyplex

Indexed keywords

ACRYLIC ACID METHYL ESTER; AMINE; COPOLYMER; DENDRIMER; ETHYLENEDIAMINE; MACROGOL; METHANOL; METHOXYPOLY(ETHYLENE GLYCOL) AMINE; METHOXYPOLY(ETHYLENE GLYCOL) BLOCK POLYAMIDOAMINE; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; COMPLEX FORMATION; DNA BINDING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; IMMUNOGENICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; NANOPARTICLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; TECHNIQUE;

EID: 0037454864     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: 10.5012/bkcs.2003.24.1.123     Document Type: Article

References (17)

1. De Smedt, S. C.; Demeester, J.; Hennink, W. E. Pharm. Res. 2000, 17(2), 113.
2. Zauner, W.; Ogris, M.; Wagner, E. Adv. Drug Deliv. Rev. 1998, 30, 97.
3. Tomalia, D. A.; Baker, H.; Dewald, J.; Hall, M.; Kallos, G.; Martin, S.; Roeck, J.; Ryder, J.; Smith, P. Polym. J. 1985, 17(1), 117.
4. Lim, Y. B.; Kim, S. M.; Lee, Y.; Lee, W. K.; Yang, T. G.; Lee, M. J.; Suh, H. Park, J. S. J. Am. Chem. Soc. 2001, 123, 2461.
5. Kavanov, A. V.; Vinogradov, S. V.; Suzdaltseva, Y. G.; Alakhov, V. Y.; Bioconjugate Chem. 1995, 6(6), 639.
6. Behr, J. P. Acc. Chem. Res. 1993, 26, 274.
7. Ledley, F. D. Hum. Gene. Ther. 1995, 6, 1129.
8. Choi, J. S.; Lee, E. J.; Choi, Y. H.; Jeong, Y. J.; Park, J. S. Bioconjugate Chem. 1999, 10, 62.
9. Choi, J. S.; Joo, D. K.; Kim, C. H.; Kim, K.; Park, J. S. J. Am. Chem. Soc. 2000, 122, 474.
10. Iyer, J.; Fleming, K.; Hammond, P. T. Macromolecules 1998, 31, 8757.
11. Tang, M. X.; Redemann, C. T.; Szoka, F. C., Jr. Bioconjugate Chem. 1996, 7, 703.
12. Bielinska, A. U.; Chen, C.; Johnson, J.; Baker, J. R., Jr. Bioconjugate Chem. 1999, 10, 843.
13. Eichman, J. D.; Bielinska, A. U.; Kukowska-Latallo, J. F.; Baker, J. R., Jr. PSTT 2000, 3(7), 232.
14. Gref, R.; Minamitake, Y.; Peracchia, M. T.; Trubetskoy, V.; Torchilin, V.; Langer, R. Science 1994, 263, 1600.
15. Han, S. O.; Mahato, R. I.; Kim, S. W. Bioconjugate Chem. 2001, 12, 337.
16. Light scattering experiments were performed at room temperature with BI-200SM Goniometer (Brookhaven Instruments Corporation) using a Lexel laser model 95 argon laser (100 mW output power at a wavelength of 514.5 nm). Correlator was PD2000 (Precision Detectors), and the scattering angle was 90°. Data were analyzed using the CONTIN algorithm. The sample was prepared by directly mixing each solution of polymer and DNA in water. The final DNA concentration was adjusted to 20 μg/mL.
17. Luo, D.; Haverstick, K.; Belcheva, N.; Han, E.; Saltzman, W. M. Macromolecules 2002, 35, 3456.