Hydrophobic D-amino acids in the design of peptide ligands for the pp60src SH2 domain1

Drug Design and Discovery

Volumn 13, Issue 3-4, 1996, Pages 75-81

  Plummer, Mark S ^a   Lunney, Elizabeth A ^a   Para, Kimberly S ^a   Vara Prasad, J V N ^a   Shahripour, Aurash ^a   Singh, Juswinder ^a   Stankovic, Charles J ^a   Humblet, Christine ^a   Fergus, James H ^a   Marks, James S ^a   Sawyer, Tomi K ^a  

^a PFIZER INC   (United States)

Author keywords

Phosphotyrosine; Src SH2 domain; Structure based drug design

Indexed keywords

DEXTRO AMINO ACID; LIGAND; PEPTIDE; PHOSPHOTYROSINE; PROTEIN KINASE P60; TRIPEPTIDE DERIVATIVE;

BINDING AFFINITY; CONFERENCE PAPER; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; HYDROPHOBICITY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; IODINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RADIOLIGAND ASSAY; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029953826     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

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