메뉴 건너뛰기




Volumn 69, Issue 1-6, 1999, Pages 117-122

Androgen-activating enzymes in the central nervous system

Author keywords

5 reductase; Flutamide; GT1 cells; LHRH; Neurons; Rat brain; Testosterone

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; DEOXYCORTICOSTERONE; ESTRADIOL; FINASTERIDE; FLUTAMIDE; GLUCOCORTICOID; GONADORELIN; GONADOTROPIN; MINERALOCORTICOID; MYELIN; PROGESTERONE; STEROID; STEROID 5ALPHA REDUCTASE; SURAMIN; TESTOSTERONE;

EID: 0344731431     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(98)00150-2     Document Type: Conference Paper
Times cited : (54)

References (48)
  • 2
    • 0023910355 scopus 로고
    • Cloning of human androgen receptor complementary DNA and localization to the X chromosome
    • Lubahn D.B., Joseph D.R., Sullivan P.M., Willard H.F., French F.S., Wilson E.M. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 240:1988;327-330.
    • (1988) Science , vol.240 , pp. 327-330
    • Lubahn, D.B.1    Joseph, D.R.2    Sullivan, P.M.3    Willard, H.F.4    French, F.S.5    Wilson, E.M.6
  • 3
    • 0021238092 scopus 로고
    • A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA binding state
    • Kovacs W.J., Griffin J.E., Weaver D.D., Carlson B.R., Wilson J.D. A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA binding state. J. Clin. Invest. 73:1984;1095-1104.
    • (1984) J. Clin. Invest. , vol.73 , pp. 1095-1104
    • Kovacs, W.J.1    Griffin, J.E.2    Weaver, D.D.3    Carlson, B.R.4    Wilson, J.D.5
  • 4
    • 0025037581 scopus 로고
    • Testosterone at high concentration interacts with the human androgen receptor similarly to dihydrotestosterone
    • Grino P.B., Griffin J.E., Wilson J.D. Testosterone at high concentration interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology. 126:1990;1165-1172.
    • (1990) Endocrinology , vol.126 , pp. 1165-1172
    • Grino, P.B.1    Griffin, J.E.2    Wilson, J.D.3
  • 5
    • 0028173882 scopus 로고
    • Steroid 5α-reductase: Two genes/two enzymes
    • Russell D.W., Wilson J.D. Steroid 5α-reductase: two genes/two enzymes. Ann. Rev. Biochem. 63:1994;6-25.
    • (1994) Ann. Rev. Biochem. , vol.63 , pp. 6-25
    • Russell, D.W.1    Wilson, J.D.2
  • 6
    • 0026723090 scopus 로고
    • Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes. Evidence for distinct physiological functions
    • Normington K., Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes. Evidence for distinct physiological functions. J. Biol. Chem. 267:1992;19548-19554.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19548-19554
    • Normington, K.1    Russell, D.W.2
  • 7
    • 0029791876 scopus 로고    scopus 로고
    • Effect of suramin on the biological activity of the two isoforms of the rat 5α-reductase
    • Poletti A., Rabuffetti M., Martini L. Effect of suramin on the biological activity of the two isoforms of the rat 5α-reductase. Steroids. 61:1996;504-505.
    • (1996) Steroids , vol.61 , pp. 504-505
    • Poletti, A.1    Rabuffetti, M.2    Martini, L.3
  • 8
    • 0029123736 scopus 로고
    • Inhibition of rat steroid 5α-reductase (isozyme 1) by suramin
    • Taylor M.F., Bhattacharyya A.K., Collins D.C. Inhibition of rat steroid 5α-reductase (isozyme 1) by suramin. Steroids. 60:1995;452-456.
    • (1995) Steroids , vol.60 , pp. 452-456
    • Taylor, M.F.1    Bhattacharyya, A.K.2    Collins, D.C.3
  • 9
    • 0030982034 scopus 로고    scopus 로고
    • MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen
    • Schwartz J.I., Tanaka W.K., Wang D.Z., Geissler L.A., Hafkin B., Gertz B.J. MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J. Clin. Endocrinol. Metab. 82:1997;1373-1377.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1373-1377
    • Schwartz, J.I.1    Tanaka, W.K.2    Wang, D.Z.3    Geissler, L.A.4    Hafkin, B.5    Gertz, B.J.6
  • 10
    • 0016359646 scopus 로고
    • Steroid 5α-reductase deficiency in man: An inherited form of male pseudohermaphroditism
    • Imperato-McGinley J., Guerrero L., Gautier T., Peterson R.E. Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 186:1974;1213-1215.
    • (1974) Science , vol.186 , pp. 1213-1215
    • Imperato-McGinley, J.1    Guerrero, L.2    Gautier, T.3    Peterson, R.E.4
  • 12
    • 0029670231 scopus 로고    scopus 로고
    • Characterization and subcellular localization of rat 5α-reductases type 1 and type 2 expressed in yeast Saccharomyces cerevisiae
    • Poletti A., Celotti F., Motta M., Martini L. Characterization and subcellular localization of rat 5α-reductases type 1 and type 2 expressed in yeast Saccharomyces cerevisiae. Biochem. J. 314:1996;1047-1052.
    • (1996) Biochem. J. , vol.314 , pp. 1047-1052
    • Poletti, A.1    Celotti, F.2    Motta, M.3    Martini, L.4
  • 13
    • 0024505324 scopus 로고
    • The kinetic mechanism of the hypothalamic progesterone 5α-reductase
    • Campell J.S., Karavolas H.J. The kinetic mechanism of the hypothalamic progesterone 5α-reductase. J. Steroid Biochem. 32:1989;283-289.
    • (1989) J. Steroid Biochem. , vol.32 , pp. 283-289
    • Campell, J.S.1    Karavolas, H.J.2
  • 14
    • 0025062320 scopus 로고
    • Kinetics properties of the 5α-reductase of testosterone in the purified myelin, in the sub-cortical white matter and in the cerebral cortex of the male rat brain
    • Poletti A., Celotti F., Melcangi R.C., Ballabio M., Martini L. Kinetics properties of the 5α-reductase of testosterone in the purified myelin, in the sub-cortical white matter and in the cerebral cortex of the male rat brain. J. Steroid Biochem. 35:1990;97-101.
    • (1990) J. Steroid Biochem. , vol.35 , pp. 97-101
    • Poletti, A.1    Celotti, F.2    Melcangi, R.C.3    Ballabio, M.4    Martini, L.5
  • 15
    • 0002187043 scopus 로고    scopus 로고
    • The 5α-reductase in the rat brain
    • in: A. R. Gennazzani, F. Petraglia and R. H. Purdy (Eds.) Parthenon Publishing, London, U.K.
    • A. Poletti, M. Rabuffetti, F. Celotti, The 5α-reductase in the rat brain. in: A. R. Gennazzani, F. Petraglia and R. H. Purdy (Eds.), The Brain: Source and Target for Sex Steroid Hormones, Parthenon Publishing, London, U.K., 1996, pp. 123-133.
    • (1996) The Brain: Source and Target for Sex Steroid Hormones , pp. 123-133
    • Poletti, A.1    Rabuffetti, M.2    Celotti, F.3
  • 17
    • 0027479169 scopus 로고
    • Differential localization of the 5α-reductase and 3α-hydroxysteroid-dehydrogenase in neuronal and glial cultures
    • Melcangi R.C., Celotti F., Castano P., Martini L. Differential localization of the 5α-reductase and 3α-hydroxysteroid-dehydrogenase in neuronal and glial cultures. Endocrinology. 132:1993;1252-1259.
    • (1993) Endocrinology , vol.132 , pp. 1252-1259
    • Melcangi, R.C.1    Celotti, F.2    Castano, P.3    Martini, L.4
  • 18
    • 0029953789 scopus 로고    scopus 로고
    • Ontogeny of 5α-reductase (type 1) messenger ribonucleic acid expression in rat brain: Early presence in germinal zones
    • Lauber M.E., Lichtensteiger W. Ontogeny of 5α-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones. Endocrinology. 137:1996;2718-2729.
    • (1996) Endocrinology , vol.137 , pp. 2718-2729
    • Lauber, M.E.1    Lichtensteiger, W.2
  • 20
    • 0026603924 scopus 로고
    • The 5α-reductase in the brain: Molecular aspects and relation to brain function
    • Celotti F., Melcangi R.C., Martini L. The 5α-reductase in the brain: molecular aspects and relation to brain function. Front. Neuroendocrinol. 13:1992;163-215.
    • (1992) Front. Neuroendocrinol. , vol.13 , pp. 163-215
    • Celotti, F.1    Melcangi, R.C.2    Martini, L.3
  • 21
    • 0030927911 scopus 로고    scopus 로고
    • Identification of type 1 5α-reductase in myelin membranes of male and female rat brain
    • Poletti A., Celotti F., Rumio C., Rabuffetti M., Martini L. Identification of type 1 5α-reductase in myelin membranes of male and female rat brain. Mol. Cell. Endocr. 129:1997;181-190.
    • (1997) Mol. Cell. Endocr. , vol.129 , pp. 181-190
    • Poletti, A.1    Celotti, F.2    Rumio, C.3    Rabuffetti, M.4    Martini, L.5
  • 22
    • 0031594582 scopus 로고    scopus 로고
    • Transient expression of the type 2 5α-reductase isozyme in the brain of the late fetal and early post-natal life
    • Poletti A., Negri-Cesi P., Rabuffetti M., Colciago A., Celotti F., Martini L. Transient expression of the type 2 5α-reductase isozyme in the brain of the late fetal and early post-natal life. Endocrinology. 139:1998;2171-2178.
    • (1998) Endocrinology , vol.139 , pp. 2171-2178
    • Poletti, A.1    Negri-Cesi, P.2    Rabuffetti, M.3    Colciago, A.4    Celotti, F.5    Martini, L.6
  • 23
    • 0018921896 scopus 로고
    • Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses and neonatal offspring
    • Weisz J., Ward I.L. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses and neonatal offspring. Endocrinology. 106:1980;306-316.
    • (1980) Endocrinology , vol.106 , pp. 306-316
    • Weisz, J.1    Ward, I.L.2
  • 24
    • 0022414159 scopus 로고
    • Nuclear and cytosolic androgen receptor levels in the limbic brain of neonatal male and female rats
    • Meaney M.J., Aitken D.H., Jensen L.K., McGinnis M.Y., McEwen B.S. Nuclear and cytosolic androgen receptor levels in the limbic brain of neonatal male and female rats. Dev. Brain Res. 23:1985;179-185.
    • (1985) Dev. Brain Res. , vol.23 , pp. 179-185
    • Meaney, M.J.1    Aitken, D.H.2    Jensen, L.K.3    McGinnis, M.Y.4    McEwen, B.S.5
  • 25
    • 0020580616 scopus 로고
    • Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurons
    • Shivers B.D., Harlan R.E., Morrel J.I., Pfaff D.W. Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurons. Nature. 304:1983;345-347.
    • (1983) Nature , vol.304 , pp. 345-347
    • Shivers, B.D.1    Harlan, R.E.2    Morrel, J.I.3    Pfaff, D.W.4
  • 26
    • 0027304746 scopus 로고
    • Absence of androgen receptors in LHRH immunoreactive neurons
    • Huang X., Harlan R.E. Absence of androgen receptors in LHRH immunoreactive neurons. Brain Res. 624:1993;309-311.
    • (1993) Brain Res. , vol.624 , pp. 309-311
    • Huang, X.1    Harlan, R.E.2
  • 28
    • 0028034494 scopus 로고
    • Steroid binding and metabolism in the LHRH-producing neuronal cell line GT1-1
    • Poletti A., Melcangi R.C., Negri-Cesi P., Maggi R., Martini L. Steroid binding and metabolism in the LHRH-producing neuronal cell line GT1-1. Endocrinology. 135:1994;2623-2628.
    • (1994) Endocrinology , vol.135 , pp. 2623-2628
    • Poletti, A.1    Melcangi, R.C.2    Negri-Cesi, P.3    Maggi, R.4    Martini, L.5
  • 29
    • 0030011810 scopus 로고    scopus 로고
    • Steroid imprinting and modulation of sexual dimorphism in the luteinizing hormone-releasing hormone neuronal system
    • Lopez F.J., Merchenthaler I., Liposits Z., Negro-Vilar A. Steroid imprinting and modulation of sexual dimorphism in the luteinizing hormone-releasing hormone neuronal system. Cell. Mol. Neurobiol. 16:1996;129-141.
    • (1996) Cell. Mol. Neurobiol. , vol.16 , pp. 129-141
    • Lopez, F.J.1    Merchenthaler, I.2    Liposits, Z.3    Negro-Vilar, A.4
  • 30
    • 0030910876 scopus 로고    scopus 로고
    • Transcriptional activities of estrogen and glucocorticoid receptors are functionally integrated at the AP-1 response element
    • Uht R.M., Anderson C.M., Webb P., Kushner P.J. Transcriptional activities of estrogen and glucocorticoid receptors are functionally integrated at the AP-1 response element. Endocrinology. 138:1997;2900-2908.
    • (1997) Endocrinology , vol.138 , pp. 2900-2908
    • Uht, R.M.1    Anderson, C.M.2    Webb, P.3    Kushner, P.J.4
  • 31
    • 0031769779 scopus 로고    scopus 로고
    • Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: Estrogenic control of galanin gene expression
    • Shen E.D., Meade E.H., Pérez M.C., Deecher D., Negro-Vilar A., Lòpez F.J. Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: estrogenic control of galanin gene expression. Endocrinology. 139:1998;939-948.
    • (1998) Endocrinology , vol.139 , pp. 939-948
    • Shen, E.D.1    Meade, E.H.2    Pérez, M.C.3    Deecher, D.4    Negro-Vilar, A.5    Lòpez, F.J.6
  • 32
    • 0030593681 scopus 로고    scopus 로고
    • ERbeta: Identification and characterization of a novel human estrogen receptor
    • Mosselman S., Polman J., Dijkema R. ERbeta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392:1996;49-53.
    • (1996) FEBS Lett. , vol.392 , pp. 49-53
    • Mosselman, S.1    Polman, J.2    Dijkema, R.3
  • 33
    • 0345097279 scopus 로고    scopus 로고
    • Are luteinizing hormone-releasing hormone secreting neurons androgen-target cells?
    • Minneapolis, MN, U.S.A., June 11-14
    • A. Poletti, M. Zanisi, R. Maggi, L. Martini, Are luteinizing hormone-releasing hormone secreting neurons androgen-target cells? Abstract of the '79th Endocrine Society Meeting', Minneapolis, MN, U.S.A., June 11-14, 1997.
    • (1997) Abstract of the '79th Endocrine Society Meeting'
    • Poletti, A.1    Zanisi, M.2    Maggi, R.3    Martini, L.4
  • 35
    • 0030467582 scopus 로고    scopus 로고
    • The distribution of estrogen receptor β mRNA in the rat hypothalamus
    • Shughrue P.J., Komm B., Merchenthaler I. The distribution of estrogen receptor β mRNA in the rat hypothalamus. Steroids. 61:1996;678-681.
    • (1996) Steroids , vol.61 , pp. 678-681
    • Shughrue, P.J.1    Komm, B.2    Merchenthaler, I.3
  • 36
    • 0031738481 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons
    • Belsham D.D., Evangelou A., Roy D., Vinh Le D., Brown T.J. Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons. Endocrinology. 139:1998;1108-1114.
    • (1998) Endocrinology , vol.139 , pp. 1108-1114
    • Belsham, D.D.1    Evangelou, A.2    Roy, D.3    Vinh Le, D.4    Brown, T.J.5
  • 38
    • 0029608727 scopus 로고
    • Roles of steroid hormones and their receptors in structural organization in the nervous system
    • Kawata M. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci. Res. 24:1995;1-46.
    • (1995) Neurosci. Res. , vol.24 , pp. 1-46
    • Kawata, M.1
  • 39
    • 0025852366 scopus 로고
    • Steroid hormones are multifactorial messengers to the brain
    • McEwen B.S. Steroid hormones are multifactorial messengers to the brain. Trends Endocrinol. Metab. 2:1991;62-67.
    • (1991) Trends Endocrinol. Metab. , vol.2 , pp. 62-67
    • McEwen, B.S.1
  • 41
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 43
    • 0026509649 scopus 로고
    • A receptor. Mechanism of action and physiological significance
    • A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38:1992;379-395.
    • (1992) Prog. Neurobiol. , vol.38 , pp. 379-395
    • Majewska, M.D.1
  • 44
    • 0026579057 scopus 로고
    • Neuroactive steroids
    • Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
    • (1992) FASEB J. , vol.6 , pp. 2311-2322
    • Paul, S.M.1    Purdy, R.H.2
  • 45
    • 0022638091 scopus 로고
    • Ovarian hormones, anticonvulsant drugs, and seizure during the menstrual cycle in women with epilepsy
    • Rosciszewske D., Buntner B., Guz I., Zawisza L. Ovarian hormones, anticonvulsant drugs, and seizure during the menstrual cycle in women with epilepsy. J. Neurol. Neurosurg. Psychiatry. 49:1986;47-51.
    • (1986) J. Neurol. Neurosurg. Psychiatry , vol.49 , pp. 47-51
    • Rosciszewske, D.1    Buntner, B.2    Guz, I.3    Zawisza, L.4
  • 46
    • 0024533243 scopus 로고
    • Pregnancy-induced alteration of GABAA receptor sensitivity in maternal brain: An antecedent of post-partum 'blues'?
    • Majewska M.D., Force-Rice F., Kalkay G. Pregnancy-induced alteration of GABAA receptor sensitivity in maternal brain: an antecedent of post-partum 'blues'? Brain Res. 482:1989;397-401.
    • (1989) Brain Res. , vol.482 , pp. 397-401
    • Majewska, M.D.1    Force-Rice, F.2    Kalkay, G.3
  • 47
    • 0030967604 scopus 로고    scopus 로고
    • Fetal death in mice lacking 5α-reductase type 1 caused by estrogen excess
    • Mahendroo M.S., Cala K.M., Landrum C.P., Russell D.W. Fetal death in mice lacking 5α-reductase type 1 caused by estrogen excess. Mol. Endocrinol. 11:1997;917-927.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 917-927
    • Mahendroo, M.S.1    Cala, K.M.2    Landrum, C.P.3    Russell, D.W.4
  • 48
    • 0029990372 scopus 로고    scopus 로고
    • 5α-Reduced androgens play a key role in murine parturition
    • Mahendroo M.S., Cala K.M., Russell D.W. 5α-Reduced androgens play a key role in murine parturition. Mol. Endocrinol. 10:1996;380-392.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 380-392
    • Mahendroo, M.S.1    Cala, K.M.2    Russell, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.