Modification of Plant Lipids for Human Health: Development of Functional Land-Based Omega-3 Fatty Acids

Journal of Nutrition

Volumn 133, Issue 12, 2003, Pages 4271-4274

  Ursin, Virginia M ^a  

^a MONSANTO COMPANY   (United States)

Author keywords

Biotechnology; Canola oil; Omega 3 fatty acids; Omega 6 fatty acids; PUFA; Stearidonic acid

Indexed keywords

CANOLA OIL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; STEARIDONIC ACID; UNCLASSIFIED DRUG; VEGETABLE OIL;

BIOSYNTHESIS; BIOTECHNOLOGY; CONFERENCE PAPER; DIETARY INTAKE; FAT INTAKE; FATTY ACID SYNTHESIS; FOOD INDUSTRY; GENETIC ENGINEERING; HUMAN; NONHUMAN; PLANT; PLANT BIOTECHNOLOGY; VEGETABLE;

BRASSICA NAPUS VAR. NAPUS;

EID: 0344306475     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.12.4271     Document Type: Conference Paper

References (20)

1. Bialostosky, K., Wright, J., Kennedy-Stephenson, J., McDowell, M. & Johnson, C. L. (2002) United States 1988-94. Dietary intake of macronutrients micronutrients and other dietary constituents. Vital Health Stat. 11: 1-168.
2. Simopoulos, A. P. (1999) Essential fatty acids in health and chronic disease. Am. J. Clin. Nutr. 70: 560S-569S.
3. Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Jr., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., Lichtenstein, A. H., Mitch, W. E., Mullis, R., Robinson, K., Wylie-Rosett, J., St. Jeor, S., Suttie, J., Tribble, D. L. & Bazzarre, T. L. (2000) AHA Dietary Guidelines: revision: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102: 2284-2299.
4. Kris-Etherton, P. M., Taylor, D. S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R. L., Zhao, G. & Etherton, T. D. (2000) Polyunsaturated fatty acids in the food chain in the United States. Am. J. Clin. Nutr. 71: 179S-188S.
5. U.S. Department of Agriculture, A. R. S. (2002) USDA National Nutrient Database for Standard Reference, Release 15. U.S. Department of Agriculture, http://www.nal.usda.gov/fnic/foodcomp.
6. Kris-Etherton, P. M., Harris, W. S. & Appel, L. J. (2003) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 23: e20-e30.
7. Mantzioris, E., Cleland, L. G., Gibson, R. A., Neumann, M. A., Demasi, M. & James, M. J. (2000) Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Am. J. Clin. Nutr. 72: 42-48.
8. Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A. & Salem, N. (2001) Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J. Lipid Res. 42: 1257-1265.
9. Sargent, J. R. & Tacon, A. G. (1999) Development of farmed fish: a nutritionally necessary alternative to meat. Proc. Nutr. Soc. 58: 377-383.
10. Naylor, R. L., Goldburg, R. J., Primavera, J. H., Kautsky, N., Beveridge, M. C., Clay, J., Folke, C., Lubchenco, J., Mooney, H. & Troell, M. (2000) Effect of aquaculture on world fish supplies. Nature 405: 1017-1024.
11. James, M. J., Ursin, V. M. & Cleland, L. G. (2003) Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am. J. Clin. Nutr. 77: 1140-1145.
12. 22 series. J. Lipid Res. 1: 139-146.
13. Kinney, A. J., Cahoon, E. B. & Hitz, W. D. (2002) Manipulating desaturase activities in transgenic crop plants. Biochem. Soc. Trans. 30: 1099-1103.
14. Kinney, A. J. & Knowlton, S. (1998) Designer oils: the high oleic acid soybean. In: Genetic Modification in the Food Industry; A Strategy for Food Quality Improvement (Roller, H. ed.), pp. 193-213. Blackie Academic and Professional, London, UK.
15. Broun, P., Gettner, S. & Somerville, C. (1999) Genetic engineering of plant lipids. Annu. Rev. Nutr. 19: 197-216.
16. Jaworski, J. & Cahoon, E. B. (2003) Industrial oils from transgenic plants. Curr. Opin. Plant Biol. 6: 178-184.
17. Huang, Y.C.S. Thurmond, J. M., Bobik, E. G., Yuan, L., Chan, G. M., Kirchener, S. J., Mukerji, P. & Knutson, D. S. (1999) Cloning of Delta 12 and Delta 6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae. Lipids 34: 649-659.
18. Knutson, D. (1999) Polyunsaturated Fatty Acids. World Intellectual Property Organization WO, WO 99/64614.
19. Fokkema, M. R., Brouwer, D. A., Hasperhoven, M. B., Martini, I. A. & Muskiet, F. A. (2000) Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. Prostaglandins Leukot. Essent. Fatty Acids 63: 287-292.
20. Foulke, J. E. (1994) Mercury in fish: cause for concern? FDA Consumer Magazine.