Effective gene transfer of lacZ and P0 into Schwann cells of P0-deficient mice

GLIA

Volumn 25, Issue 2, 1999, Pages 165-178

  Guénard, Véronique ^a   Schweitzer, Beat ^a   Flechsig, Eckhard ^b   Hemmi, Silvio ^b   Martini, Rudolf ^a,c   Suter, Ueli ^a   Schachner, Melitta ^a,d  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Adenovirus; FK506; Gene therapy; Inherited peripheral neuropathy; Peripheral nervous system

Indexed keywords

BETA GALACTOSIDASE; ENZYME ACTIVITY; GENE TRANSFER; NERVE CELL;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HISTOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LAC OPERON; MALE; MICE; MYELIN P0 PROTEIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SCHWANN CELLS; SCIATIC NERVE;

EID: 0344267738     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(19990115)25:2<165::AID-GLIA7>3.3.CO;2-C     Document Type: Article

References (60)

1. Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, Perricaudet M, Kahn A, Peschanski MR. 1993. Transfer of a foreign gene into the brain using adenovirus vector. Nat Genet 3:224-228.
2. Austin JM, Gordon S. 1981. F4/80: A monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 10:805-815.
3. Bartsch S, Bartsch U, Dörries U, Faissner A, Weller A, Ekblom P, Schachner M. 1992. Expression of tenascin in the developing and adult cerebellar cortex. J Neurosci 12:736-749.
4. Bennett J, Tanabe T, Sun D, Zeng Y, Kjeldbye H, Gouras P, Maguire AM. 1996. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nat Med 2:49-654.
5. Brideau RJ, Carter PB, McMaster WR, Mason DW, Williams AF. 1980. Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur J Immunol 10:1253-1260.
6. Byrnes AP, Rusby JE, Wood MJA, Charlton HM. 1995. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 66:1015-1024.
7. Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ. 1993. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3:219-223.
8. Davidson BL, Bohn MC. 1997. Recombinant adenovirus: a gene transfer vector for study and treatment of CNS diseases. Exp Neurol 144:125-130.
9. De Jonghe P, Timmerman V, Nelis E, Martin JJ, Van Broeckhoven C. 1997. Charcot-Marie-Tooth disease and related peripheral neuropathies. J Periph Nervous Syst 4:370-387.
10. Dyck PJ, Chance P, Lebo R, Carney JA. 1993. Hereditary motor and sensory neuropathies. In: Dyck PJ, Thomas PK, Griffin JW, Low PA, and Podulso JF, editors. Peripheral Neuropathy: Philadelphia. W.B. Saunders Co p 1094-1136.
11. Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC, Van der Erb AJ. 1996. Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 7:215-222.
12. Fukumoto T, McMaster WR, Williams AF. 1982. Mouse monoclonal antibodies against rat major histocompatibility antigens: Two Ia antigens and expression of Ia and class I antigens in rat thymus. Eur J Immunol 12:237-243.
13. Gabreëls-Festen AAWM, Hoogendijk JE, Meijerink PHS, Gabreëls FJM, Bohluis PA, van Beersum S, Kulkens T, Nelis E, Jennekens FGI, de Visser M, van Engelen BGM, Van Broeckhoven C, Mariman ECM. 1996. Two divergent types of nerve pathology in patients with different P0 mutations in Charcot-Marie-Tooth disease Neurology 47:761-765.
14. Giese KP, Martini R, Lemke G, Soriano P, Schachner M. 1992. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell 71:565-576.
15. Graham FL, Prevec L. 1991. Manipulation of adenovirus vectors. In: Ed Murray, editor. Gene transfer and expression protocol, vol. 7. Clifton, NJ: The Human Press Inc. p 109-128.
16. Griffiths IR. 1996. Myelin mutants: model systems for the study of normal and abnormal myelination. BioEssays 18:789-797.
17. Guénard V, Montag D, Schachner M, Martini R. 1996. Onion bulb cells in mice deficient for myelin genes share antigenic properties with immature, differentiated non-myelinating, and denervated Schwann cells. Glia 18:27-38.
18. Hayasaka K, Himoro M, Sato W, Takada G, Uyemura K, Shimizu N, Bird TD, Conneally PM, Chance PF. 1993a. Charcot-Marie-Tooth neuropathy type IB is associated with mutations of the myelin P0 gene. Nat Genet 5:31-34.
19. Hayasaka K, Himoro M, Sawaishi Y, Nanao K, Takahashi T, Takada G, Nicholson GA, Ouvrier RA, Tachi N. 1993b. De novo mutation of the myelin P0 gene in Déjérine-Sottas disease (hereditary motor and sensory neuropathy type III). Nat Genet 5:265-268.
20. Hermens WTJMC, Giger RJ, Holtmaat AJGD, Dijkhuizen PA, Houweling DA, Verhaagen J. 1997. Transient gene transfer to neurons and glia: Analysis of adenoviral vector performance in the CNS and PNS. J Neurosci Methods 71:85-98.
21. Hodes ME, Dlouhy SR. 1996. The proteolipid protein gene: double, double ... and trouble. Am J Hum Genet 59:12-15.
22. Karpati G, Lochmüller H, Nalbantoglu J, Durham H. 1996. The principles of gene therapy for the nervous system. Trends Neurosci 19:49-54.
23. Kulkens T, Bolhuis PA, Wolterman RA, Kemp S, te Nijenhuis S, Valentijn LJ, Hensels GW, Jennekens FGI, de Visser M, Hoogendijk JE, Baas F. 1993. Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot-Marie-Tooth disease type 1B. Nat Genet 5:35-39.
24. Le Gal La Salle G, Robert J-J, Berrard S, Ridoux V, Stratford-Perricaudet LD, Perricaudet M, Mallet J. 1993. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259:988-990.
25. Lochmüller H, Petrof BJ, Pari G, Larochelle N, Dodelet V, Wang Q, Allen C, Prescott S, Massie B, Nalbantoglu J, Karpati G. 1996. Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. Gene Ther 3:706-716.
26. Lupski JR, Garcia CA, Parry GJ, Patel PI. 1991. Charcot-Marie-Tooth polyneuropathy syndrome: clinical, electrophysiological, and genetic aspects. In: Appel S, editor. Current Neurology. Chicago: Mosby-Yearbook. p 1-25.
27. Malo D, Skamene E. 1994. Genetic control of host resistance to infection. Trends Genet 10:365-371.
28. Martini R, Zielasek J, Toyka KV, Giese KP, Schachner M. 1995a. P0-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies. Nat Genet 11:281-286.
29. Martini R, Mohajeri MH, Kasper S, Giese KP, Schachner M. 1995b. Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin. J Neurosci 15:4488-4495.
30. Martini R. 1997. Animal models for inherited peripheral neuropathies. J Anat 191:321-336.
31. Martini R, Schachner M. 1997. Molecular bases of myelin formation as revealed by investigations on mice deficient in glial cell surface molecules. Glia 19:298-310.
32. Michou AI, Santoro L, Christ M, Julliard V, Pavirani A, Mehtali M. 1997. Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression. Gene Ther 4:473-482.
33. Naef R, Adlkofer K, Lescher B, Suter U. 1997. Aberrant protein trafficking in Trembler suggests a disease mechanism for hereditary human peripheral neuropathies. Mol Cell Neurosci 9:13-25.
34. Naef R, Suter U. 1998. Many facets of the peripheral myelin protein PMP22 in myelination and disease. Microscopic Res Techniques 41:359-371.
35. Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
36. Patel PI, Lupski, JR. 1994. Charcot-Marie-Tooth disease: a new paradigm for the mechanism of inherited disease. Trends Genet 10:128-133.
37. Paterson DJ, Jefferies WA, Green JR, Brandon MR, Corthesy P, Puklavec M, Williams AF. 1987. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 24:1281-1290.
38. Ridet JL, Privat A. 1995. Gene therapy in the central nervous system: direct versus indirect gene therapy. J Neurosci Res 42:287-293.
39. Scherer SS, Chance PF. 1995. Myelin genes: getting the dosage right. Nat Genet 11:26-228.
40. Scherer SS. 1997. The biology and pathobiology of Schwann cells. Curr Opin Neurobiol 10:386-397.
41. Schneider SD, Rusconi S, Seger RA, Hossle JP. 1997. Adenovirusmediated gene transfer into monocyte-derived macrophages of patients with X-linked chronic granulomatous disease: ex vivo correction of deficient respiratory burst. Gene Ther 4:524-532.
42. Schnell L, Schneider R, Berman MA, Perry VH, Schwab ME. 1997. Lymphocyte recruitment following spinal cord injury in mice is altered by prior viral exposure. Eur J Neurosci, 9:1000-1007.
43. Schulte-Merker S, Ho RK, Herrmann BG, Nüsslein-Volhard C. 1992. The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development 116:1021-1032.
44. Shy ME, Tani M, Shi Y-j, Whyatt SA, Chbihi T, Scherer SS, Kamholz J. 1995. An adenoviral vector can transfer lacZ expression into Schwann cells in culture and in sciatic nerve. Ann Neurol 38:429-436.
45. Slack RS, Miller FD. 1996. Viral vectors for modulating gene expression in neurons. Curr Opin Neurobiol 6: 576-583.
46. Smith TAG, White BD, Gardner JM, Kaleko M, McClelland A. 1996. Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther 3:496-502.
47. Snyder SH, Sabatini DM. 1995. Immunophilins and the nervous system. Nat Med 1:32-37.
48. Sorensen J, Haase G, Krarup C, Gilgenkrankz H, Kahn A, Schmalbruch H. 1998. Gene transfer to Schwann cells after peripheral nerve injury: A delivery system for therapeutic agents. Ann. Neurol. 43:205-211.
49. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. 1992. Widespread long-term transfer to mouse skeletal muscles and heart. J Clin Invest 90:626-630.
50. Suter U. 1997. Keeping nerves well wrapped up. Curr Biol 7:R21-R23.
51. Suter U, Snipes GJ. 1995. Biology and genetics of hereditary motor and sensory neuropathies. Annu Rev Neurosci 18:45-75.
52. Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Ben Younes Chennoufi A, Seitanidou T, Babinet C, Charnay P. 1994. Krox-20 controls myelination in the peripheral nervous system. Nature 371:796-799.
53. Vilquin JT, Guerette B, Kinoshita I, Roy B, Goulet M Gravel C, Roy R, Tremblay JP. 1995. FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum Gene Ther 6:1391-1401.
54. Warner LE, Hilz MJ, Appel SH, Killian JM, Kolodny EH, Karpati G, Carpenter S, Watters GV, Wheeler C, Witt D, Bodell A, Nelis E, Van Broeckhoven C, Lupski JR. 1996. Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Déjérine-Sottas, and congenital hypomyelination. Neuron 17:451-460.
55. Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR. 1998. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat Genet, 18:382-384.
56. Wood MJA, Charlton HM, Wood KJ, Kajiwara K, Byrnes AP. 1996. Immune responses to adenovirus vectors in the nervous system. Trends Neurosci 19:497-501.
57. Wrabetz L, Feltri ML, Quattrini A, Arona M, Trapp B, Messing A. 1996. Increased P0 glycoprotein gene dosage causes a dysmyelinating peripheral neuropathy in transgenic mice. Soc Neurosci Abstr 21:1990.
58. Xiao X, Li J, McCown TJ, Samulski RJ. 1997. Gene transfer by adeno-associated virus vectors in the central nervous system. Exp Neurol 144:113-124.
59. Zielasek J, Martini R, Toyka KV. 1996. Functional abnormalities in P0-deficient mice resemble human hereditary neuropathies linked to P0 gene mutations. Muscle Nerve 19:946-952.
60. Zorick TS, Syroid DE, Arroyo E, Scherer SS, Lemke G. 1996. The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation. Mol Cell Neurosci 8:129-145.