1 Isolation and Propagation of Human Dendritic Cells

Methods in Microbiology

Volumn 25, Issue C, 1998, Pages 504-538

  Caux, C ^a   Dezutter Dambuyant, C ^b   Liu, Y J ^a   Banchereau, J ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c BAYLOR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956964263     PISSN: 05809517     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0580-9517(08)70691-3     Document Type: Article

References (163)

1. Ali A., Patterson S., Cruickshank K., Rudge P., Dalgleish A.G., and Knight S.C. Dendritic cells infected in vitro with human T cell leukaemia/lymphoma virus type-1 (HTLV-1); enhanced lymphocytic proliferation and tropical spastic paraparesis. Clin. Exp. Immunol. 94 (1993) 32-37
2. Ardavin C., Wu L., Li C.L., and Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362 (1993) 761-763
3. Austyn J.D. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183 (1996) 1287-1292
4. Austyn J.M., Kupiec-Weglinksi J.W., Hankins D.F., and Morris P.J. Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone. J. Exp. Med. 167 (1988) 646-651
5. Backx B., Broeders L., Bot F.J., and Lowenberg B. Positive and negative effects of tumor necrosis factor on colony growth from highly purified normal marrow progenitors. Leukemia 5 (1991) 66-70
6. Banchereau J., Bazan F., Blanchard D., Brière F., Galizzi J.P., van Kooten C., Liu Y.J., Rousset F., and Saeland S. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12 (1994) 881-922
7. Barfoot R., Denham S., Gyure L.A., Hall J.G., Hobbs S.M., Jackson L.E., and Robertson D. Some properties of dendritic macrophages from peripheral lymph. Immunology 68 (1989) 233-239
8. Bhardwaj N. Interactions of viruses with dendritic cells: a double-edged sword. J. Exp. Med. 186 (1997) 795-799
9. Bhardwaj N., Friedman S.M., Cole B.C., and Nisanian A.J. Dendritic cells are potent antigen-presenting cells for microbial superantigens. J. Exp. Med. 175 (1992) 267-273
10. Bhardwaj N., Young J.W., Nisanian A.J., Baggers J., and Steinman R.M. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178 (1993) 633-642
11. + T cells. J. Clin. Invest. 94 (1994) 797-807
12. Bhardwaj N., Hodtsev A.S., Nisanian A., Kabak S., Friedman S.M., Cole B.C., and Posnett D.N. Human T-cell responses to Mycoplasma arthritidis-derived superantigen. Infect. Immun. 62 (1994) 135-144
13. Birbeck M.S., Breathnach A.S., and Everall J.D. An electron microscopic study of basal melanocytes and high level clear cells (Langerhans' cells) in vitiligo. J. Invest. Dermatol. 37 (1961) 51-64
14. Björck P., Florès-Romo L., and Liu Y.J. Human interdigitating dendritic cells directly stimulate CD40-activated naive B cells. Eur. J. Immunol. 27 (1997) 1266-1274
15. Boczkowski D., Nair S.K., Snyder D., and Gilboa E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 184 (1996) 465-472
16. Borkowski T.A., Letterio J.J., Farr A.G., and Udey M.C. A role for endogenous transforming growth factor β1 in Langerhans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184 (1996) 2417-2422
17. Burkly L., Hession C., Ogata L., Reilly C., Marconi L.A., Olson D., Tizard R., Cate R., and Lo D. Expression of re/B is required for the development of thymic medulla and dendritic cells. Nature 373 (1995) 531-536
18. + T cells. Science 257 (1992) 383-387
19. Cameron P.U., Lowe M.G., Crowe S.M., O'Doherty U., Pope M., Gezelter S., and Steinman R.M. Susceptibility of dendritic cells to HIV-1 infection in vitro. J. Leukocyte Biol. 56 (1994) 257-265
20. Caux C., and Banchereau J. In vitro regulation of dendritic cell development and function. In: Whetton T., and Gordon J. (Eds). Blood Cell Biochemistry (1996), Plenum Press, London 263-301
21. + hematopoietic progenitor cells. Blood 75 (1990) 2292-2298
22. Caux C., Dezutter-Dambuyant C., Schmitt D., and Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360 (1992) 258-261
23. + progenitors. J. Exp. Med. 177 (1993) 1815-1820
24. Caux C., Massacrier C., Vanbervliet B., Barthélémy C., Liu Y.J., and Banchereau J. Interleukin-10 inhibits T cell alloreaction induced by human dendritic cells. Int. Immunol. 6 (1994) 1177-1185
25. Caux C., Massacrier C., Vanbervliet B., Dubois B., van Kooten C., Durand I., and Banchereau J. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180 (1994) 1263-1272
26. Caux C., Vanbervliet B., Massacrier C., Azume M., Okumura K., Lanier L.L., and Banchereau B. B70/B7--2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180 (1994) 1841-1847
27. + T cells and process soluble antigen. J. Immunol. 155 (1995) 5427-5435
28. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. J. Exp. Med. 184 (1996) 695-706
29. + hematopoietic progenitor cells. Blood 87 (1996) 2376-2385
30. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. II. Functional analysis. Blood 90 (1997) 1458-1470
31. Cella M., Scheidegger D., Palmer-Lehmann K., Lane P., Lanzavecchia A., and Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of Interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184 (1996) 747-752
32. Cella M., Sallusto F., and Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opinion Immunol. 9 (1997) 10-16
33. Celluzzi C.M., Mayordomo J.I., Storkus W.J., Lotze M.T., and Falo L.D. Peptide-pulsed dendritic cells induce antigen-specifiC., CTL-mediated protective tumor immunity. J. Exp. Med. 183 (1996) 283-287
34. Chapuis F., Rozenzwajg M., Yagello M., Ekman M., Biberfield P., and Gluckman J.C. Differentiation of human dendritic cells from monocytes in vitro. Eur. J. Immunol. 27 (1997) 431-441
35. + T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176 (1992) 1431-1437
36. Crow M.K., and Kunkel H.G. Human dendritic cells: major stimulators of the autologous and allogeneic mixed leucocyte reactions. Clin. Exp. Immunol. 49 (1982) 338-346
37. Defrance T., Vanbervliet B., Pene J., and Banchereau J. Human recombi-nant IL-4 induces activated B lymphocytes to produce IgG and IgM. J. Immunol. 141 (1988) 2000-2005
38. Defrance T., Vanbervliet B., Brière F., Durand I., Rousset F., and Banchereau J. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete Immunoglobulin A. J. Exp. Med. 175 (1992) 671-682
39. de Saint-Vis B., Fugier-Vivier I., Massacrier C., Vanbervliet B., Ait-Yahia S., Banchereau J., Liu Y.J., Lebecque S., and Caux C. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. (1998) in press.
40. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P., Urbain J., Leo O., and Moser M. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184 (1996) 1413-1424
41. Dezutter-Dambuyant C. Culture of Langerhans cells and co-culture with lymphoid cells: relevance to toxicology and pharmacology. Toxic. in vitro 5 (1991) 585-589
42. Dezutter-Dambuyant C., and Schmitt D. Epidermal Langerhans cells and HIV-1 infection. Immunol. Lett. 39 (1993) 33-37
43. Dezutter-Dambuyant C., Schmitt D.A., Dusserre N., Hanau D., Kolbe H.V.J., Kieny M.P., Cazenave J.P., Schmitt D., Pasquali J.L., Olivier R., Gazzolo L., and Thivolet J. Interaction of human epidermal Langerhans cells with HIV-1 viral envelope proteins (gpl20 and gpl60s) involves a receptor-mediated endocytosis independent of the CD4 T4A epitope. J. Dermatol. 18 (1991) 377-392
44. Dubois B., Vanbervliet B., Fayette J., Massacrier C., van Kooten C., Briere F., Banchereau J., and Caux C. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med. 185 (1997) 941-951
45. Durie F.H., Fava R.A., Foy T.M., Aruffo A., Ledbetter J.A., and Noelle R.J. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261 (1993) 1328-1330
46. Durie F.H., Aruffo A., Ledbetter J., Crassi K.M., Green W.R., and Fast L.D. Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease. J. Clin. Invest. 94 (1994) 1333-1338
47. Enk A.H., and Katz S.I. Identification and induction of keratinocyte-derived IL-10. J. Immunol. 149 (1992) 92-95
48. Fayette J., Dubois B., Vandenabeele S., Bridon J.M., Vanbervliet B., Durand I., Banchereau J., Caux C., and Briere F. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J. Exp. Med. 185 (1997) 1909-1918
49. Flamand V., Sornasse T., Thielemans K., Demanet C., Bakkus M., Bazin H., Tielemans F., Leo O., Urbain J., and Moser M. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24 (1994) 605-610
50. + hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells. J. Exp. Med. 185 (1997) 341-349
51. Fossu M.S. Lymph-borne dendritic leucocytes do not recirculate, but enter the lymph node paracortex to become interdigitating cells. Scand. J. Immunol. 27 (1988) 97-105
52. Francotte M., and Urbain J. Enhancement of antibody responses by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype. Proc. Natl Acad. Sci. USA 82 (1985) 8149-8152
53. Freudenthal P.S., and Steinman R.M. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc. Natl Acad. Sci. USA 87 (1990) 7698-7702
54. Fugier-Vivier I., Servet-Delprat C., Rivailler P., Rissoan M.C., Liu Y.J., and Rabourdin-Combe C. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of DC and T cells. J. Exp. Med. 186 (1997) 813-823
55. Galy A., Travis M., Cen D., and Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3 (1995) 459-473
56. Garrone P., Neidhardt E.M., Garcia E., Galibert L., van Kooten C., and Banchereau J. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182 (1995) 1265-1273
57. Ghanekar S., Zheng L., Logar A., Navratil J., Borowski L., Gupta P., and Rinaldo C. Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus. J. Immunol. 157 (1996) 4028-4036
58. Girolomoni G., and Ricciardi-Castagnoli P. Dendritic cells hold promise for immunotherapy. Immunol. Today 18 (1997) 102-104
59. Grabbe S., and Granstein R.D. Presentation of tumor antigens by Langerhans cells and other dendritic cells. In: Moll H. (Ed). The Immune Functions of Epidermal Langerhans Cells (1995), Austin, USA: Springer-Verlag/R.G. Landes, Berlin/Austin, TX 159-175
60. Grewal I.S., Xu J., and Flavell R.A. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378 (1995) 617-620
61. + T cells. J. Exp. Med. 186 (1997) 801-812
62. Grouard G., Durand I., Filgueira L., Banchereau J., and Liu Y.J. Dendritic cells capable of stimulating T cells in germinal centers. Nature 384 (1996) 364-367
63. Grouard G., Rissoan M.C., Filgueira L., Durand I., Banchereau J., and Liu Y.J. The enigmatic plasmacytoid T cells develop into dendritic cells with IL-3 and CD40-ligand. J. Exp. Med. 185 (1997) 1101-1111
64. Hanau D., Fabre M., Schmitt D.A., Stampf J.-L., Garaud J.-C., Bieber T., Grosshans E., Benezra C., and Cazenave J.-P. Human epidermal Langerhans cells internalize by receptor-mediated endocytosis T6 (CD1 'NA1/34') surface antigen. Birbeck granules are involved in the intracellular traffic of the antigen. J. Invest. Dermatol. 89 (1987) 172-177
65. Harkiss G.D., Hopkins J., and McConnell I. Uptake of antigen by afferent lymph dendritic cells mediated by antibody. Eur. J. Immunol. 20 (1990) 2367-2373
66. Hart D.N.J., and McKenzie J.L. Isolation and characterization of human tonsil dendritic cells. J. Exp. Med. 168 (1988) 157-160
67. Hart D.N.J., and McKenzie J.L. Interstitial dendritic cells. Int. Rev. Immunol 6 (1990) 128-149
68. Havenith C.E., Breedijk A.J., Betjes M.G., Calame W., Beelen R.H., and Hoefsmit E.C. T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells. Am. J. Respir. Cell. Mol. Biol. 8 (1993) 319-324
69. Inaba K., and Steinman R.M. Protein-specific helper T lymphocyte formation initiated by dendritic cells. Science 229 (1985) 475-479
70. Inaba K., Granelli-Piperno A., and Steinman R.M. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and man. Proc. Natl Acad. Sci. USA 80 (1983) 6041-6045
71. Inaba K., Witmer M.D., and Steinman R.M. Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells, during primary antibody responses in vitro. J. Exp. Med. 160 (1984) 858-876
72. Inaba K., Schuler G., Witmer M.D., Valinksy J., Atassi B., and Steinman R.M. Immunologic properties of purified epidermal Langerhans cells. J. Exp. Med. 164 (1986) 605-613
73. + cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166 (1987) 182-194
74. Inaba K., Hosono M., and Inaba M. Thymic dendritic cells and B cells: isolation and function. Int. Rev. Immunol. 6 (1990) 117-122
75. Inaba K., Metlay J.P., Crowley M.T., and Steinman R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specifiC., MHC-restricted T cells in situ. J. Exp. Med. 172 (1990) 631-640
76. Jacobsen S.E.W., Ruscetti F.W., Dubois C.M., and Keller J.R. Tumor necrosis factor a directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation. J. Exp. Med. 175 (1992) 1759-1772
77. Jiang W., Swiggard W.J., Heufler C., Peng M., Mirza A., Steinman R.M., and Nussenzweig M.C. The receptor DC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375 (1995) 151-155
78. Kamanaka M., Yu P., Yasui T., Yosha K., Kawabe T., Horii T., Kishimoto T., and Kikutani H. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 4 (1996) 275-281
79. Kasinrerk W., Baumruker T., Majdi C.O., Knapp W., and Stockinger H. CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony-stimulating factor. J. Immunol. 150 (1993) 579-584
80. Knight S.C., and Stagg A.J. Antigen-presenting cell types. Curr. Opin. Immunol. 5 (1993) 374-382
81. Knight S.C., Farrant J., and Bryan A. Non-adherent, low density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 57 (1986) 595-603
82. Knight S.C., Macatonia S.E., Bedford P.A., and Patterson S. Dendritic cells and HIV infection. In: Racz P., Dijkstra C.D., and Gluckman J.C. (Eds). Accessory Cells in HIV and other Retroviral Infections (1991), Karger, Basel 145-154
83. Koch F., Stanzl U., Jennewein P., Janke K., Heufler C., Kämpgen E., Romani N., and Schuler G. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184 (1996) 741-746
84. Kripke M.L., Munn C.G., Jeevan A., Tang J.-M., and Bucana C. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J. Immunol. 145 (1990) 2833-2838
85. Kronin V., Winkel K., Süss G., Kelso A., Heath W., Kirberg J., von Boehmer H., and Shortman K. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J. Immunol. 157 (1996) 3819-3827
86. Kudo S., Matsuno K., Ezaki T., and Ogawa M. A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation. J. Exp. Med. 185 (1997) 777-784
87. Kupiec-Weglinski J.W., Austyn J.M., and Morris P.J. Migration patterns of dendritic cells in the mouse. Traffic from blood, and T cell-dependent and independent entry to lymphoid tissues. J. Exp. Med. 167 (1988) 632-645
88. Langhoff E., Terwilliger E.R., Bos H.J., Kalland K.H., Poznansky M.C., Baron O.M.L., and Haseltine W.A. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc. Natl Acad. Sri. USA 88 (1991) 7998-8002
89. Larsen C.P., Steinman R.M., Witmer-Pack M.D., Hankins D.F., Morris P.J., and Austyn J.M. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172 (1990) 1483-1494
90. Lenz A., Heine M., Schuler G., and Romani N. Human and murine dermis contain dendritic cells. J. Clin. Invest. 92 (1993) 2587-2596
91. + T lymphocytes to peptide antigen in vivo. J. Immunol. 151 (1993) 6742-6750
92. Liu L.M., and MacPherson G.G. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177 (1993) 1299-1307
93. Liu Y.J., Xu J., de Bouteiller O., Parha M.C.L., Grouard G., Djossou O., de Saint-Vis B., Lebecque S., Banchereau J., and Moore K.W. Follicular dendritic cells specifically express the long CR2/CD21 isoform. J. Exp. Med. 185 (1997) 167-170
94. Macatonia S.E., Knight S.C., Edwards A.J., Griffiths S., and Fryer P. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. J. Exp. Med. 166 (1987) 1654-1667
95. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5 (1993) 1119-1128
96. + T cells. J. Immunol. 154 (1995) 5071-5079
97. Maraskovsky E., Brasel K., Teepe M., Roux E.R., Lyman S.D., Shortman K., and McKenna H.J. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell sub-populations identified. J. Exp. Med. 184 (1996) 1953-1962
98. Matsuno K., Ezaki T., Kudo S., and Uehara Y. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J. Exp. Med. 183 (1996) 1865-1878
99. Mayordomo J.I., Zorina T., Storkus W.J., Zitvogel L., Cellulzzi C., Falo L.D., Melief C.J., Ildstad S.T., Martin Kast W., Deleo A.B., and Lotze M.T. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med. 1 (1995) 1297-1302
100. Metlay J.P., Puré E., and Steinman R.M. Control of the immune response at the level of antigen-presenting cells: a comparison of the function of dendritic cells and B lymphocytes. Adv. Immunol. 47 (1989) 45-116
101. Moll H. Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis. Immunol. Today 14 (1993) 383-387
102. Moll H., Flohé S., and Blank C. Langerhans in cutaneous leishmaniasis. In: Moll H. (Ed). The Immune Functions of Epidermal Langerhans Cells (1995), Springer-Verlag/R. G. Landes, Berlin/Austin, TX 159-175
103. Moore M.A.S. Clinical implications of positive and negative hemato-poietic stem cell regulators. Blood 78 (1991) 1-19
104. Nestle F.O., Zheng X.-G., Thompson C.B., Turka L.A., and Nickoloff B.J. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol. 151 (1993) 6535-6545
105. Notarangelo L.D., Duse M., and Ugazio A.G. Immunodeficiency with hyper-IgM (HIM. Immunodef. Rev. 3 (1992) 101-122
106. O'Doherty U., Steinman R.M., Peng M., Cameron P.U., Gezelter S., Kopeloff I., Swiggard W.J., Pope M., and Bhardwaj N. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immuno-stimulatory dendritic cells after culture in monocyte-conditioned medium. J. Exp. Med. 178 (1993) 1067-1078
107. O'Doherty U., Peng M., Gezelter S., Swiggard W.J., Betjes M., Bhardwaj N., and Steinman R.M. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82 (1994) 487-493
108. Paglia P., Chiodoni C., Rodolfo M., and Colombo M.P. Murine dendritic cells loaded in vitro with soluble protein prime CTL against tumor antigen in vivo. J. Exp. Med. 183 (1996) 317-322
109. Péguet-Navarro J., Dalbiez-Gauthier C., Dezutter-Dambuyant C., and Schmitt D. Dissection of human Langerhans cells' allostimulatory function: the need for an activation step for full development of accessory function. Eur. J. Immunol. 23 (1993) 376-382
110. Péguet-Navarro J., Dalbiez-Gauthier C., Rattis F.M., van Kooten C., Banchereau J., and Schmitt D. Functional expression of CD40 antigen on human epidermal Langerhans cells. J. Immunol. 155 (1995) 4241-4247
111. Peters J.H., Gieseler R., Thiele B., and Steinbach F. Dendritic cells: from ontogenetic orphans to myelomonocytic descendants. Immunol. Today 17 (1996) 273-278
112. + peripheral blood monocytes. J. Immunol. 157 (1996) 3850-3859
113. Piemonti L., Bernasconi S., Luini W., Trobonjaca Z., Minty A., Allavena P., and Mantovani A. IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF. Eur. Cytokine Network 6 (1995) 245-252
114. Pope M., Betjes M.G.H., Romani N., Hirmand H., Cameron P.U., Hoffman L., Gezelter S., Schuler G., and Steinman R.M. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78 (1994) 389-398
115. Porcelli S., Morita C.T., and Brenner M.B. CD 1b restricts the response of human CD4--8-T lymphocytes to a microbial antigen. Nature 360 (1992) 593-597
116. Puré E., Inaba K., Crowley M.T., Tardelli L., Witmer-Pack M.D., Ruberti G., Fathman G., and Steinman R.M. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of MHC class II molecules and expression of invariant chain. J. Exp. Med. 172 (1990) 1459-1469
117. Ray A., Schmitt D., Dezutter-Dambuyant C., Fargier M.C., and Thivolet J. Reappearance of CD1a antigenic sites after endocytosis on human Langerhans cells evidenced by immunogold labeling. J. Invest. Dermatol. 92 (1989) 217-224
118. Reid C.D.L., Fryer P.R., Clifford C., Kirk A., Tikerpae J., and Knight S.C. Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood. Blood 76 (1990) 1139-1149
119. + progenitors in human bone marrow. J. Immunol. 149 (1992) 2681-2688
120. Reise Sousa C., Stahl P.D., and Austyn J.M. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178 (1993) 509-519
121. dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells. Blood 87 (1996) 5196-5206
122. Romani N., Lenz A., Glassl H., Stossel H., Stanzl U., Majdi C.O., Fritsch P., and Schuler G. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J. Invest. Dermatol. 93 (1989) 600-609
123. Romani N., Schuler G., and Fritsch P. Identification and phenotype of epidermal Langerhans cells in vivo and in vitro. In: Schuler G. (Ed). Epidermal Langerhans Cells (1991), CRC Press, Boca Raton, FL 49-86
124. Romani N., Gruner S., Brang D., Kämpgen E., Lenz A., Trockenbacher B., Konwalinka G., Fritsch P.O., Steinman R.M., and Schuler G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180 (1994) 83-93
125. + hematopoietic precursor cells. Blood 87 (1996) 535-544
126. Sallusto F., and Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179 (1994) 1109-1118
127. Sallusto F., Cella M.L., Danieli C., and Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class Ii compartment: down-regulation by cytokines and bacterial products. J. Exp. Med. 182 (1995) 389-400
128. Santiago-Schwarz F., Belilos E., Diamond B., and Carsons S.E. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J. Leukocyte Biol. 52 (1992) 274-281
129. Saunders D., Lucas K., Ismaili J., Wu L., Maraskovsky E., Dunn A., and Shortman K. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 184 (1996) 2185-2196
130. Schmitt D.A., Hanau D., Bieber T., Dezutter-Dambuyant C., Schmitt D., Fabre M., Pauly G., and Cazenave J.-P. Human epidermal Langerhans cells express only the 40-kilodalton Feγ receptor (FcRII. J. Immunol. 144 (1990) 4284-4290
131. Schuler G., and Steinman R.M. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161 (1985) 526-546
132. Schuler G., Auböck J., and Linert J. Enrichment of epidermal Langerhans cells by immunoadsorption to Staphylococcus aureus cells. J. Immunol. 130 (1983) 2008-2010
133. + blood progenitors for anti-cancer therapy. Exp. Hematol. 23 (1995) 1463-1471
134. Sornasse T., Flamand V., de Becker G., Bazin H., Tielemans F., Thielemans K., Urbain J., Oberdan L., and Moser M. Antigen-pulse dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 175 (1992) 15-21
135. Steinman R.M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9 (1991) 271-296
136. Steinman R.M., and Swanson J. The endocytic activity of dendritic cells. J. Exp. Med. 182 (1995) 283-288
137. Steinman R.M., and Witmer M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl Acad. Sci. USA 75 (1978) 5132-5136
138. Stingl G., and Shevach E. Langerhans cells as antigen-presenting cells. In: Schuler G. (Ed). Epidermal Langerhans Cells (1991), CRC Press, Boca Raton, FL 159-190
139. Streilein J.W., and Grammer S.F. In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes. J. Immunol. 143 (1989) 3925-3933
140. + hemopoietic progenitors. J. Immunol. 157 (1996) 1499-1507
141. + hematopoietic progenitor cells. Blood 87 (1996) 1292-1302
142. Strunk D., Egger C., Leitner G., Hanau D., and Stingl G. A skin homing molecule defines the Langerhans cell progenitor in human peripheral blood. J. Exp. Med. 185 (1997) 1131-1136
143. + epidermal cells. J. Immunol. 137 (1986) 2460-2467
144. Süss G., and Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183 (1996) 1789-1796
145. + bone marrow precursors cultured with c-kit-ligand, GM-CSF, and TNFα. J. Immunol. 154 (1995) 5851-5861
146. + cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells. Int. Immunol. 5 (1993) 849-857
147. Tang A., Amagai M., Granger L.G., Stanley J.R., and Udey M.C. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361 (1993) 82-85
148. Teunissen M.B.M. Dynamic nature and function of epidermal Langerhans cells in vivo and in vitro: a review, with emphasis on human Langerhans cells. Histochem. J. 24 (1992) 697-716
149. Thomas R., Davis L.S., and Lipsky P.E. Isolation and characterization of human peripheral blood dendritic cells. J. Immunol. 150 (1993) 821-834
150. Van Voorhis W.C., Valinsky J., Hoffman E., Luban J., Hair L.S., and Steinman R.M. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J. Exp. Med. 158 (1983) 171-191
151. Wang J., Taniuchi I., Maekawa Y., Howard M., Cooper M.D., and Watanabe T. Expression and function of Fas antigen on activated murine B cells. Eur. J. Immunol. 26 (1996) 92-96
152. Weih R., Carrasco D., Durha M.S.K., Barton D.S., Rizzo C.A., Ryseck R.-P., Lira S.A., and Bravo R. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the Nf-κ B/Rel family. Cell 80 (1995) 331-340
153. Weissman D., Li Y., Ananworanich J., Zhou L.-J., Adelsberger J., Tedder T.F., Baseler M., and Fauci A.S. Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proc. Natl Acad. Sci. USA 92 (1995) 826-830
154. + cord blood progenitor cells. In: Banchereau J., and Schmitt D. (Eds). Dendritic Cells in Fundamental and Clinical Immunology (1995), Plenum Press, London 371-374
155. Williams L.A., Egner W., and Hart D.N. Isolation and function of human dendritic cells. Int. Rev. Cytol 153 (1994) 41-103
156. Wu L., Li C.L., and Shortman K. Thymic dendritic cell precursors: relationship to the T-lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184 (1996) 903-911
157. Young J.W., and Steinman R.M. Accessory cell requirements for the mixed leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cell. Immunol. 111 (1988) 167-182
158. + helper T cells. J. Exp. Med. 171 (1990) 1315-1332
159. Young J.W., and Steinman R.M. The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem Cells 14 (1996) 376-387
160. + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumour necrosis factor a. J. Exp. Med. 182 (1995) 1111-1120
161. Zhou L.J., and Tedder T.F. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154 (1995) 3821-3835
162. + dendritic cells. Proc. Natl Acad. Sci. USA 93 (1996) 2588-2592
163. Zitvogel L., Mayordomo J.I., Tjandrawan T., DeLeo A.B., Clarke M.R., Lotze M.T., and Storkus W.J. Therapy of murine tumors with tumor peptide pulsed dendritic cells: dependence on T cells, B7 costimulation, and Th1-associated cytokines. J. Exp. Med. 183 (1996) 87-97