1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 5, 1999, Pages 685-690

  Rewinkel, J B M ^a   Lucas, H ^a   Van Galen, P J M ^a   Noach, A B J ^a   Van Dinther, T G ^a   Rood, A M M ^a   Jenneboer, A J S M ^a   Van Boeckel, C A A ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOISOQUINOLINE; BENZAMIDINE; ISOQUINOLINE DERIVATIVE; N (2 NAPHTHYLSULFONYL)GLYCYL 4 AMIDINOPHENYLALANINE PIPERIDIDE; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG DESIGN; DRUG PENETRATION; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; THROMBOSIS;

ADMINISTRATION, ORAL; ANTICOAGULANTS; BENZAMIDINES; CACO-2 CELLS; DIPEPTIDES; DRUG DESIGN; HUMANS; ISOQUINOLINES; PIPERIDINES; THROMBIN; TRYPSIN INHIBITORS;

ANIMALIA;

EID: 0033535401     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00069-4     Document Type: Article

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