Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes

Journal of Medicinal Chemistry

Volumn 41, Issue 12, 1998, Pages 2068-2075

  Bone, Roger ^a   Lu, Tianbao ^a   Illig, Carl R ^a   Soll, Richard M ^a   Spurlino, John C ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE DERIVATIVE; CARBONYL DERIVATIVE; FIBRINOGEN RECEPTOR ANTAGONIST; GUANIDINE DERIVATIVE; HIRUDIN; PHENYL GROUP; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SOLVENT; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; DRUG CONFORMATION; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AMINOPYRIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ENZYME INHIBITORS; GUANIDINES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PROTEIN CONFORMATION; THROMBIN;

EID: 0032482311     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970796l     Document Type: Article

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