Formycin A and its N-methyl analogues, specific inhibitors of E. coli purine nucleoside phosphorylase (PNP): Induced tautomeric shifts on binding to enzyme, and enzyme → ligand fluorescence resonance energy transfer

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1476, Issue 1, 2000, Pages 109-128

  Kierdaszuk, Borys ^a   Modrak Wójcik, Anna ^a   Wierzchowski, Jacek ^b   Shugar, David ^a,c  

^a UNIVERSITY OF WARSAW   (Poland)

^b SIEDLCE UNIVERSITY OF NATURAL SCIENCES AND HUMANITIES   (Poland)

^c INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Fluorescence energy transfer; Fluorescence quenching; Formycin A; Formycin B; Inhibitor; Purine nucleoside phosphorylase; Tautomerism

Indexed keywords

FORMYCIN; FORMYCIN B; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; ENERGY TRANSFER; ENZYME BINDING; ENZYME INHIBITION; ESCHERICHIA COLI; FLUORESCENCE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; STRUCTURE ANALYSIS;

BINDING SITES; ENZYME INHIBITORS; ESCHERICHIA COLI; FLUORESCENCE; FORMYCINS; LIGANDS; MATHEMATICS; MOLECULAR STRUCTURE; PHOSPHATES; PURINE-NUCLEOSIDE PHOSPHORYLASE; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0343550348     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00225-3     Document Type: Article

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