Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: Characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 135-140

  Messer, William S ^a   Rajeswaran, W G ^a   Cao, Yang ^a   Zhang, Hai Jun ^a   El Assadi, Afif A ^a   Dockery, Colleen ^a   Liske, Jill ^a   O'Brien, John ^a   Williams, Frederick E ^a   Huang, Xi Ping ^a   Wroblewski, Mary E ^a   Nagy, Peter I ^a   Peseckis, Steven M ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

Alzheimer's disease; CDD 0102; Memory function; Molecular modeling; Muscarinic receptor; Site directed mutagenesis; Xanomeline

Indexed keywords

5 (3 ETHYL 1,2,4 OXADIAZOL 5 YL) 1,4,5.6 TETRAHYDROPYRIMIDINE TRIFLUOROACETIC ACID; CDD 0102; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; TETRAHYDROPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; XANOMELINE;

ALZHEIMER DISEASE; ANIMAL MODEL; BINDING AFFINITY; BRAIN INJURY; CELL LINE; CHOLINERGIC SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMORY; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; ANIMALS; DRUG DESIGN; INJECTIONS, INTRAPERITONEAL; LIGANDS; MALE; MODELS, MOLECULAR; MUSCARINIC AGONISTS; MUTAGENESIS, SITE-DIRECTED; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; THIADIAZOLES;

EID: 0343294314     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00026-6     Document Type: Article

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