Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 10, 1996, Pages 1605-1615

  Ojo, Babatunde ^a,b   Dunbar, Philip G ^a,c   Durant, Graham J ^a,d   Nagy, Peter I ^a   Huzl III, James J ^a   Periyasamy, Sumudra ^a   Ngur, Dan O ^a   El Assadi, Afif A ^a   Hoss, Wayne P ^a   Messer, William S ^a  

^a UNIVERSITY OF TOLEDO   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

^d CeNeS Pharmaceuticals plc   (United States)

Author keywords

Amidine derivatives; M1 agonists; Molecular modeling; Muscarinic receptors; Selectivity

Indexed keywords

AMIDINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; RAT;

ANIMALIA;

EID: 0030271779     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00152-6     Document Type: Article

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